The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: New potential therapeutic targets?

Lung Cancer

Volumn 65, Issue 1, 2009, Pages 49-55

  Stacher, Elvira ^a   Gruber Mösenbacher, Ulrike ^b   Halbwedl, Iris ^a   Dei Tos, Angelo Paolo ^c   Cavazza, Alberto ^d   Papotti, Mauro ^e   Carvalho, Lina ^f   Huber, Monika ^g   Ermert, Leander ^h   Popper, Helmut H ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b ACADEMIC TEACHING HOSPITAL FELDKIRCH   (Austria)

^c General Hospital of Treviso   (Italy)

^d S MARIA NUOVA HOSPITAL   (Italy)

^e UNIVERSITY OF TURIN   (Italy)

^f UNIVERSITY OF COIMBRA   (Portugal)

^g OTTO WAGNER HOSPITAL   (Austria)

^h Institute of Pathology   (Germany)

Author keywords

Immunohistochemistry; Mesenchymal tumors; Pulmonary angiosarcomas; Pulmonary haemangioendotheliomas; Tie2; VEGF; VEGFR

Indexed keywords

ANGIOPOIETIN RECEPTOR; BEVACIZUMAB; SUNITINIB; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VATALANIB;

ADULT; AGED; ANGIOSARCOMA; ARTICLE; CANCER DIAGNOSIS; CANCER THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMANGIOENDOTHELIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PULMONARY EPITHELOID ANGIOSARCOMA; PULMONARY EPITHELOID HEMANGIOENDOTHELIOMA; SIGNAL TRANSDUCTION; TUMOR CELL;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HEMANGIOENDOTHELIOMA, EPITHELIOID; HEMANGIOSARCOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; RECEPTOR, TIE-2; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 67349175599     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2008.10.031     Document Type: Article

References (29)

1. Scott G.A., and Rosai J. Spindle cell hemangioendothelioma. Report of seven additional cases of a recently described vascular neoplasm. Am J Dermatopathol 10 (1988) 281-288
2. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
3. Hiratsuka S., Maru Y., Okada A., Seiki M., Noda T., and Shibuya M. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 61 (2001) 1207-1213
4. Wilgus T.A., Ferreira A.M., Oberyszyn T.M., Bergdall V.K., and Dipietro L.A. Regulation of scar formation by vascular endothelial growth factor. Lab Invest 88 (2008) 579-590
5. Tanigawa N., Amaya H., Matsumura M., and Shimomatsuya T. Correlation between expression of vascular endothelial growth factor and tumor vascularity, and patient outcome in human gastric carcinoma. J Clin Oncol 15 (1997) 826-832
6. Calvo A., Catena R., Noble M.S., Carbott D., Gil-Bazo I., Gonzalez-Moreno O., et al. Identification of VEGF-regulated genes associated with increased lung metastatic potential: functional involvement of tenascin-C in tumor growth and lung metastasis. Oncogene (2008)
7. Gu Y., Qi X., and Guo S. Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: a retrospective study of 61 cases. Clin Exp Metastasis (2008)
8. Matsumoto T., and Claesson-Welsh L. VEGF receptor signal transduction. Sci STKE 2001 (2001) RE21
9. Alam A., Herault J.P., Barron P., Favier B., Fons P., Delesque-Touchard N., et al. Heterodimerization with vascular endothelial growth factor receptor-2 (VEGFR-2) is necessary for VEGFR-3 activity. Biochem Biophys Res Commun 324 (2004) 909-915
10. Mori Y., Sahara H., Matsumoto K., Takahashi N., Yamazaki T., Ohta K., et al. Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3′-sulfoquinovosyl-1′-monoacylglycerol, targeting angiogenesis. Cancer Sci 99 (2008) 1063-1070
11. Wu X., Li Z., Yao M., Wang H., Qu S., Chen X., et al. Identification and characterization of a novel peptide ligand of Tie2 for targeting gene therapy. Acta Biochim Biophys Sin (Shanghai) 40 (2008) 217-225
12. Bremnes R.M., Camps C., and Sirera R. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 51 (2006) 143-158
13. Yuan A., Yu C.J., Chen W.J., Lin F.Y., Kuo S.H., Luh K.T., et al. Correlation of total VEGF mRNA and protein expression with histologic type, tumor angiogenesis, patient survival and timing of relapse in non-small-cell lung cancer. Int J Cancer 89 (2000) 475-483
14. Breiteneder-Geleff S., Soleiman A., Kowalski H., Horvat R., Amann G., Kriehuber E., et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 154 (1999) 385-394
15. Nakamura K., Zen Y., Sato Y., Kozaka K., Matsui O., Harada K., et al. Vascular endothelial growth factor, its receptor Flk-1, and hypoxia inducible factor-1alpha are involved in malignant transformation in dysplastic nodules of the liver. Hum Pathol 38 (2007) 1532-1546
16. Soker S., Kaefer M., Johnson M., Klagsbrun M., Atala A., and Freeman M.R. Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype. Am J Pathol 159 (2001) 651-659
17. Hashimoto M., Ohsawa M., Ohnishi A., Naka N., Hirota S., Kitamura Y., et al. Expression of vascular endothelial growth factor and its receptor mRNA in angiosarcoma. Lab Invest 73 (1995) 859-863
18. Arbiser J.L., Larsson H., Claesson-Welsh L., Bai X., LaMontagne K., Weiss S.W., et al. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. Am J Pathol 156 (2000) 1469-1476
19. Fayette J., Martin E., Piperno-Neumann S., Le Cesne A., Robert C., Bonvalot S., et al. Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases. Ann Oncol 18 (2007) 2030-2036
20. Dail D.H., Liebow A.A., Gmelich J.T., Friedman P.J., Miyai K., Myer W., et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer 51 (1983) 452-464
21. Travis W.D., Brambilla E., Müller-Hermelink H.K., and Harris C.C. World Health Organization classification of tumours. Pathology and genetics of tumors of the lung, pleura, thymus and heart (2004), IARC Press, Lyon
22. Fletcher C.D.M., Unni K.K., and Mertens F. World Health Organization classification of tumours. Pathology and genetics of tumors of soft tissue and bone (2002), IARC Press, Lyon
23. Kempson R.L., Fletcher C.D.M., Evans H., Hendrickson M.R., and Sibley R.K. Atlas of tumor pathology. Tumors of the soft tissues (2001), Armed Forces Institute of Pathology, Washington DC
24. D'Adamo D.R., Anderson S.E., Albritton K., Yamada J., Riedel E., Scheu K., et al. Phase II study of doxorubicin and bevacizumab for patients with metastatic soft-tissue sarcomas. J Clin Oncol 23 (2005) 7135-7142
25. Verweij J., Lee S.M., Ruka W., Buesa J., Coleman R., van Hoessel R., et al. Randomized phase II study of docetaxel versus doxorubicin in first- and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: a study of the European organization for research and treatment of cancer soft tissue and bone sarcoma group. J Clin Oncol 18 (2000) 2081-2086
26. Fata F., O'Reilly E., Ilson D., Pfister D., Leffel D., Kelsen D.P., et al. Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face. Cancer 86 (1999) 2034-2037
27. Koch M., Nielsen G.P., and Yoon S.S. Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas. J Surg Oncol 97 (2008) 321-329
28. Gruber-Moesenbacher U., and Morresi-Hauf AP. HH Glomangiomyopericytoma arising in a diffuse and nodular myofibromatosis-like process in the lung with vascular endothelial growth factor receptor 3 expression. Arch Pathol Lab Med 132 2 (2007) 284
29. Ilan N., Tucker A., and Madri J.A. Vascular endothelial growth factor expression, beta-catenin tyrosine phosphorylation, and endothelial proliferative behavior: a pathway for transformation?. Lab Invest 83 (2003) 1105-1115