Effect of naloxone on perceived exertion and exercise capacity during maximal cycle ergometry

Journal of Applied Physiology

Volumn 93, Issue 6, 2002, Pages 2023-2028

  Sgherza, Anthony L ^a   Axen, Kenneth ^a,b   Fain, Randi ^b   Hoffman, Robert S ^b   Dunbar, Christopher C ^a   Haas, François ^b,c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Endogenous opioids; Lactate threshold; Peak oxygen consumption; Physiological fatigue

Indexed keywords

NALOXONE; OPIATE; OPIATE ANTAGONIST; PLACEBO; LACTIC ACID; NARCOTIC ANTAGONIST; OPIATE PEPTIDE;

ADULT; ARTICLE; ATHLETE; BICYCLE ERGOMETRY; BLOOD PRESSURE; CARBON DIOXIDE TENSION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EXERCISE; EXHAUSTION; FEMALE; HEART RATE; HUMAN; MALE; OXYGEN CONSUMPTION; PRIORITY JOURNAL; WORK CAPACITY; DRUG EFFECT; EXERCISE TEST; FATIGUE; METABOLISM; PERCEPTION; SPORT;

ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; EXERCISE TEST; EXERTION; FATIGUE; FEMALE; HEART RATE; HUMANS; LACTIC ACID; MALE; NALOXONE; NARCOTIC ANTAGONISTS; OPIOID PEPTIDES; OXYGEN CONSUMPTION; PERCEPTION; SPORTS;

EID: 0036891692     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00521.2002     Document Type: Article

References (27)

1. Borg GA. A category scale with ratio properties for intermodal and interindividual comparisons. In: Psychophysical Judgement and the Process of Perception: Proceedings of the 22nd International Congress of Psychology, edited by Geissler HG and Petzold P. Amsterdam: North Holland, 1980, p. 25-34.
2. Borg GA. Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14: 377-381, 1982.
3. Carr DB and Lipkowski SW. Neuropeptides and pain. Agressologie 31: 173-177, 1990.
4. Griffis C, Kaufman RD, and Ward SA. Naloxone and the ventilatory response to exercise in man. Eur J Appl Physiol 55: 624-629, 1986.
5. Gullestad L, Dolva LØ, Aase J, and Kjershus J. Interaction of naloxone and timolol on maximal exercise capacity and the subjective perception of fatigue. Int J Sports Med 10: 259-263, 1989.
6. Hickey MS, Franke WD, Herbert WG, Walberg-Rankin J, and Lee JC. Opioid antagonism, perceived exertion and tolerance to exercise-thermal stress. Int J Sports Med 13: 326-331, 1992.
7. Janal MN, Colt EWD, Clark WC, and Glusman M. Pain sensitivity, mood, and plasma endocrine levels in man following long-distance running: Effects of naloxone. Pain 19: 13-25, 1984.
8. Killian KJ, Leblanc P, Martin DH, Summers E, Jones NL, and Campbell EJM. Exercise capacity and ventilatory, circulatory, and symptom limitations in patients with chronic airflow limitations. Am Rev Respir Dis 146: 935-940, 1992.
9. Killian KJ, Summers E, Jones NL, and Campbell EJM. Dyspnea and leg effort during incremental cycle ergometry. Am Rev Respir Dis 145: 1339-1345, 1992.
10. Leventhal H and Everhart D. Emotion, pain, and physical illness. In: Emotions in Personality and Psychopathology, edited by Izard CE. New York: Plenum, 1979, p. 263-298.
11. Martin WR. Naloxone. J Intern Med 85: 765-768, 1976.
12. McMurray RG, Sheps DS, and Guinan DM. Effects of naloxone on maximal stress testing in females. J Appl Physiol 56: 436-440, 1984.
13. Ngai SH, Berkowitz BA, Yang JC, Hempstead J, and Spector S. Pharmacokinetics of naloxone in rats and in man: Basis for its potency and short duration of action. Anesthesiology 44: 398-401, 1976.
14. Olson GA, Olson RD, and Kastin AJ. Endogenous opiates: 1993. Peptides 15: 1513-1556, 1994.
15. Pokorski M and Lahiri S. Effect of naloxone on carotid body chemoreception and ventilation in the cat. J Appl Physiol 51: 1533-1538, 1981.
16. Roberston RJ. Central signals of perceived exertion during dynamic exercise. Med Sci Sports Exerc 14: 390-396, 1982.
17. Rubin PC. Opiate peptides in blood pressure regulation in man. Clin Sci (Lond) 66: 625-630, 1094.
18. Ryan ED and Kovacic CR. Pain tolerance and athletic participation. Percept Mot Skills 22: 383-390, 1966.
19. Scott V and Gijsbers K. Pain perception in competitive swimmers. Br Med J 283: 91-93, 1981.
20. Staessen J, Fiocchi R, Bouillon R, Fagard R, Lijnen P, Moerman E, De Schaepdryver A, and Amery A. The nature of opioid involvement in the hemodynamic respiratory and humeral responses to exercise. Circulation 72: 982-990, 1985.
21. Sue DY, Wasserman K, Morrica RB, and Cassaburi R. Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease: Use of the V-slope method for anaerobic threshold determination. Chest 94: 931-938, 1988.
22. Surbey GD, Andrew GM, Cervenko FW, and Hamilton PP. Effects of naloxone on exercise performance. J Appl Physiol 57: 674-679, 1984.
23. Thoren P, Floras JS, Hoffman P, and Seals DR. Endorphins and exercise: Physiological mechanisms and clinical implications. Med Sci Sports Exerc 22: 417-428, 1990.
24. Wasserman K, Hansen JE, Sue DY, Whipp BJ, and Casaburi R. Physiology of exercise. In: Principles of Exercise Testing and Interpretation (3rd ed.). Philadelphia, PA: Lea & Febiger, 1994, p. 112-131.
25. Wasserman K, Whipp BJ, Koyal SN, and Cleary MG. Effect of carotid body resection on ventilatory and acid-base control during exercise. J Appl Physiol 39: 354-358, 1975.
26. Willer JC, Boureau F, Dauthier C, and Bonora M. Study of naloxone in normal awake man: Effects on heart rate and respiration. Neuropharmacology 18: 469-472, 1979.
27. Yeadon M and Kitchen I. Opiates and respiration. Prog Neurobiol 33: 1-16, 1989.