Skin cancer after transplantation

Transplantation Reviews

Volumn 23, Issue 3, 2009, Pages 178-189

  Kovach, Bradley T ^a   Stasko, Thomas ^b  

^a Florida Coastal Dermatology Associates   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AZATHIOPRINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DACARBAZINE; DICLOFENAC; DOXORUBICIN; EPIRUBICIN; ETRETIN; FLUOROURACIL; IMIQUIMOD; INTERLEUKIN 2; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; RETINOID; TACROLIMUS; TEMOZOLOMIDE; VINCRISTINE;

ACTINIC KERATOSIS; ARTICLE; BASAL CELL CARCINOMA; CANCER RISK; CANCER STAGING; CARCINOGENESIS; CLINICAL FEATURE; CRYOSURGERY; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; EARLY DIAGNOSIS; GRAFT RECIPIENT; GRAFT REJECTION; HIGH RISK POPULATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KAPOSI SARCOMA; LIFESTYLE; MELANOMA; MERKEL CELL TUMOR; NONHUMAN; ORGAN TRANSPLANTATION; PATIENT EDUCATION; PHOTODYNAMIC THERAPY; QUALITY OF LIFE; RISK FACTOR; SKIN CANCER; SKIN SURGERY; SQUAMOUS CELL CARCINOMA; SUN EXPOSURE; SURGICAL TECHNIQUE; SURVIVAL; VERRUCA VULGARIS;

EID: 67349163206     PISSN: 0955470X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trre.2009.02.004     Document Type: Article

References (104)

1. American Cancer Society. Statistics for 2007. Available at:. http://www.cancer.org/docroot/STT/stt_0.asp Accessed September 11, 2007
2. Berg D., and Otley C.C. Skin cancer in organ transplant recipients: epidemiology, pathogenesis, and management. J Am Acad Dermatol 47 (2002) 1-17 [quiz 18-20]
3. Penn I. Cancers in renal transplant recipients. Adv Ren Replace Ther 7 (2000) 147-156
4. Jensen P., Hansen S., Moller B., et al. Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol 40 (1999) 177-186 [see comments]
5. Hartevelt M.M., Bavinck J.N., Kootte A.M., Vermeer B.J., and Vandenbroucke J.P. Incidence of skin cancer after renal transplantation in The Netherlands. Transplantation 49 (1990) 506-509
6. Lindelof B., Sigurgeirsson B., Gabel H., and Stern R.S. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol 143 (2000) 513-519
7. Penn I. The effect of immunosuppression on pre-existing cancers. Transplantation 55 (1993) 742-747
8. Taylor A.E., and Shuster S. Skin cancer after renal transplantation: the causal role of azathioprine. Acta Derm Venereol 72 (1992) 115-119
9. Ramsay H.M., Fryer A.A., Reece S., Smith A.G., and Harden P.N. Clinical risk factors associated with nonmelanoma skin cancer in renal transplant recipients. Am J Kidney Dis 36 (2000) 167-176
10. Stasko T., Brown M.D., Carucci J.A., et al. Guidelines for the management of squamous cell carcinoma in organ transplant recipients. Dermatol Surg 30 (2004) 642-650
11. Shamanin V., zur Hausen H., Lavergne D., et al. Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. J Natl Cancer Inst 88 (1996) 802-811 [see comments]
12. Otley C.C., Coldiron B.M., Stasko T., and Goldman G.D. Decreased skin cancer after cessation of therapy with transplant-associated immunosuppressants. Arch Dermatol 137 (2001) 459-463
13. Leigh I.M., Buchanan J.A., Harwood C.A., Cerio R., and Storey A. Role of human papillomaviruses in cutaneous and oral manifestations of immunosuppression. J Acquir Immune Defic Syndr 21 (1999) S49-S57
14. Frezza E.E., Fung J.J., and van Thiel D.H. Non-lymphoid cancer after liver transplantation. Hepatogastroenterology 44 (1997) 1172-1181
15. Euvrard S., Kanitakis J., Pouteil-Noble C., et al. Comparative epidemiologic study of premalignant and malignant epithelial cutaneous lesions developing after kidney and heart transplantation. J Am Acad Dermatol 33 (1995) 222-229
16. Ducloux D., Carron P.L., Rebibou J.M., et al. CD4 lymphocytopenia as a risk factor for skin cancers in renal transplant recipients. Transplantation 65 (1998) 1270-1272
17. Fortina A.B., Caforio A.L., Piaserico S., et al. Skin cancer in heart transplant recipients: frequency and risk factor analysis. J Heart Lung Transplant 19 (2000) 249-255
18. Otley C.C., Cherikh W.S., Salasche S.J., McBride M.A., Christenson L.J., and Kauffman H.M. Skin cancer in organ transplant recipients: effect of pretransplant end-organ disease. J Am Acad Dermatol 53 (2005) 783-790
19. Kasiske B.L., Snyder J.J., Gilbertson D.T., and Wang C. Cancer after kidney transplantation in the United States. Am J Transplant 4 (2004) 905-913
20. Danpanich E., and Kasiske B.L. Risk factors for cancer in renal transplant recipients.[comment]. Transplantation 68 (1999) 1859-1864
21. Gruber S.A., Gillingham K., Sothern R.B., Stephanian E., Matas A.J., and Dunn D.L. De novo cancer in cyclosporine-treated and non-cyclosporine-treated adult primary renal allograft recipients. Clin Transplant 8 (1994) 388-395
22. Roeger L.S., Sheil A.G.R., Disney A.P.S., Mathew T.H., and Amiss N. Risk factors associated with the development of squamous cell carcinomas in immunosuppressed renal transplant recipients. Clin Transpl 6 (1992) 202-2111
23. Saigal S., Norris S., Muiesan P., Rela M., Heaton N., and O'Grady J. Evidence of differential risk for posttransplantation malignancy based on pretransplantation cause in patients undergoing liver transplantation. Liver Transpl 8 (2002) 482-487
24. Mithoefer A.B., Supran S., and Freeman R.B. Risk factors associated with the development of skin cancer after liver transplantation. Liver Transpl 8 (2002) 939-944
25. Rivas J.M., and Ullrich S.E. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 149 (1992) 3865-3871
26. Vink A.A., Strickland F.M., Bucana C., et al. Localization of DNA damage and its role in altered antigen-presenting cell function in ultraviolet-irradiated mice. J Exp Med 183 (1996) 1491-1500
27. Seiffert K., and Granstein R.D. Neuropeptides and neuroendocrine hormones in ultraviolet radiation-induced immunosuppression. Methods 28 (2002) 97-103
28. Bavinck J.N., De Boer A., Vermeer B.J., et al. Sunlight, keratotic skin lesions and skin cancer in renal transplant recipients. British Journal of Dermatology 129 (1993) 242-249
29. Liddington M., Richardson A.J., Higgins R.M., et al. Skin cancer in renal transplant recipients. British Journal of Surgery 76 (1989) 1002-1005
30. Bouwes Bavinck J.N., Hardie D.R., Green A., et al. The risk of skin cancer in renal transplant recipients in Queensland, Australia. A follow-up study. Transplantation 61 (1996) 715-721
31. Fortina A.B., Piaserico S., Caforio A.L., et al. Immunosuppressive level and other risk factors for basal cell carcinoma and squamous cell carcinoma in heart transplant recipients. Arch Dermatol 140 (2004) 1079-1085
32. Moloney F.J., Comber H., O'Lorcain P., O'Kelly P., Conlon P.J., and Murphy G.M. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol 154 (2006) 498-504
33. Hojo M., Morimoto T., Maluccio M., et al. Cyclosporine induces cancer progression by a cell-autonomous mechanism. [see comments]. Nature 397 (1999) 530-534
34. Moore D.E., Sik R.H., Bilski P., Chignell C.F., and Reszka K.J. Photochemical sensitization by azathioprine and its metabolites. Part 3. A direct EPR and spin-trapping study of light-induced free radicals from 6-mercaptopurine and its oxidation products. Photochem Photobiol 60 (1994) 574-581
35. Kelly G.E., Meikle W., and Sheil A.G. Effects of immunosuppressive therapy on the induction of skin tumors by ultraviolet irradiation in hairless mice. Transplantation 44 (1987) 429-434
36. Yarosh D.B., Pena A.V., Nay S.L., Canning M.T., and Brown D.A. Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol 125 (2005) 1020-1025
37. Stockfleth E., Nindl I., Sterry W., Ulrich C., Schmook T., and Meyer T. Human papillomaviruses in transplant-associated skin cancers. Dermatol Surg 30 (2004) 604-609
38. Jackson S., and Storey A. E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage. Oncogene 19 (2000) 592-598
39. Jackson S., Harwood C., Thomas M., Banks L., and Storey A. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev 14 (2000) 3065-3073
40. Blohme I., and Larko O. Skin lesions in renal transplant patients after 10-23 years of immunosuppressive therapy. Acta Derm Venereol 70 (1990) 491-494
41. Ong C.S., Keogh A.M., Kossard S., Macdonald P.S., and Spratt P.M. Skin cancer in Australian heart transplant recipients. J Am Acad Dermatol 40 (1999) 27-34
42. Harwood C.A., Proby C.M., McGregor J.M., Sheaff M.T., Leigh I.M., and Cerio R. Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series. J Am Acad Dermatol 54 (2006) 290-300
43. Martinez J.C., Otley C.C., Stasko T., et al. Defining the clinical course of metastatic skin cancer in organ transplant recipients: a multicenter collaborative study. Arch Dermatol 139 (2003) 301-306
44. Sheil A.G.R., Disney A.P.S., Mathew T.H., and Amiss N. De novo malignancy emerges as a major cause of morbidity and late failure in renal transplantation. Transplant Proc 25 (1993) 1383-1384
45. Bouwes Bavinck J.N., Euvrard S., Naldi L., et al. Keratotic skin lesions and other risk factors are associated with skin cancer in organ-transplant recipients: a case-control study in The Netherlands, United Kingdom, Germany, France, and Italy. J Invest Dermatol 127 (2007) 1647-1656
46. Carucci J.A., Martinez J.C., Zeitouni N.C., et al. In-transit metastasis from primary cutaneous squamous cell carcinoma in organ transplant recipients and nonimmunosuppressed patients: clinical characteristics, management, and outcome in a series of 21 patients. Dermatol Surg 30 (2004) 651-655
47. Clayton A.S., and Stasko T. Treatment of nonmelanoma skin cancer in organ transplant recipients: review of responses to a survey. J Am Acad Dermatol 49 (2003) 413-416
48. Perrett C.M., McGregor J.M., Warwick J., et al. Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy. Br J Dermatol 156 (2007) 320-328
49. Ben M'barek L., Mebazaa A., Euvrard S., et al. 5% topical imiquimod tolerance in transplant recipients. Dermatology 215 (2007) 130-133
50. Ulrich C., Busch J.O., Meyer T., et al. Successful treatment of multiple actinic keratoses in organ transplant patients with topical 5% imiquimod: a report of six cases. Br J Dermatol 155 (2006) 451-454
51. Brown V.L., Atkins C.L., Ghali L., Cerio R., Harwood C.A., and Proby C.M. Safety and efficacy of 5% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial. Arch Dermatol 141 (2005) 985-993
52. Kovach B.T., Sams H.H., and Stasko T. Systemic strategies for chemoprevention of skin cancers in transplant recipients. Clin Transplant 19 (2005) 726-734
53. Buckman S.Y., Gresham A., Hale P., et al. COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis 19 (1998) 723-729
54. Higashi Y., Kanekura T., and Kanzaki T. Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression. Int J Cancer 86 (2000) 667-671
55. Tripp C.S., Blomme E.A., Chinn K.S., Hardy M.M., LaCelle P., and Pentland A.P. Epidermal COX-2 induction following ultraviolet irradiation: suggested mechanism for the role of COX-2 inhibition in photoprotection. J Invest Dermatol 121 (2003) 853-861
56. Bachelor M.A., and Bowden G.T. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol 14 (2004) 131-138
57. Gibson G.E., O'Grady A., Kay E.W., and Murphy G.M. Low-dose retinoid therapy for chemoprophylaxis of skin cancer in renal transplant recipients. J Eur Acad Dermatol Venereol 10 (1998) 42-47
58. Rook A., Jaworsky C., Nguyen T., et al. Beneficial effect of low-dose systemic retinoid in combination with topical tretinoin for the treatment and prophylaxis of premalignant and malignant skin lesions in renal transplant recipients. Tranplantation (1995)
59. Hatoum A., El-Sabban M.E., Khoury J., Yuspa S.H., and Darwiche N. Overexpression of retinoic acid receptors alpha and gamma into neoplastic epidermal cells causes retinoic acid-induced growth arrest and apoptosis. Carcinogenesis 22 (2001) 1955-1963
60. Rudkin G.H., Carlsen B.T., Chung C.Y., et al. Retinoids inhibit squamous cell carcinoma growth and intercellular communication. J Surg Res 103 (2002) 183-189
61. Rosenthal D.S., Roop D.R., Huff C.A., et al. Changes in photo-aged human skin following topical application of all-trans retinoic acid. J Invest Dermatol 95 (1990) 510-515
62. Blokx W.A., Smit J.V., de Jong E.M., Link M.M., van de Kerkhof P.C., and Ruiter D.J. Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients. Arch Dermatol 138 (2002) 61-65
63. Dragieva G., Hafner J., Dummer R., et al. Topical photodynamic therapy in the treatment of actinic keratoses and Bowen's disease in transplant recipients. Transplantation 77 (2004) 115-121
64. Dragieva G., Prinz B.M., Hafner J., et al. A randomized controlled clinical trial of topical photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratoses in transplant recipients. Br J Dermatol 151 (2004) 196-200
65. Sadek H., Azli N., Wendling J.L., et al. Treatment of advanced squamous cell carcinoma of the skin with cisplatin, 5-fluorouracil, and bleomycin. Cancer 66 (1990) 1692-1696
66. Shin D.M., Glisson B.S., Khuri F.R., et al. Phase II and biologic study of interferon alfa, retinoic acid, and cisplatin in advanced squamous skin cancer. J Clin Oncol 20 (2002) 364-370
67. Guthrie Jr. T.H., Porubsky E.S., Luxenberg M.N., Shah K.J., Wurtz K.L., and Watson P.R. Cisplatin-based chemotherapy in advanced basal and squamous cell carcinomas of the skin: results in 28 patients including 13 patients receiving multimodality therapy. J Clin Oncol 8 (1990) 342-346
68. Khansur T., and Kennedy A. Cisplatin and 5-fluorouracil for advanced locoregional and metastatic squamous cell carcinoma of the skin. Cancer 67 (1991) 2030-2032
69. Otley C.C., Berg D., Ulrich C., et al. Reduction of immunosuppression for transplant-associated skin cancer: expert consensus survey. Br J Dermatol 154 (2006) 395-400
70. Mathew T., Kreis H., and Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant 18 (2004) 446-449
71. Kahan B.D., Yakupoglu Y.K., Schoenberg L., et al. Low incidence of malignancy among sirolimus/cyclosporine-treated renal transplant recipients. Transplantation 80 (2005) 749-758
72. Kauffman H.M., Cherikh W.S., Cheng Y., Hanto D.W., and Kahan B.D. Maintenance immunosuppression with target-of-rapamycin inhibitors is associated with a reduced incidence of de novo malignancies. Transplantation 80 (2005) 883-889
73. Campistol J.M., Gutierrez-Dalmau A., and Torregrosa J.V. Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma. Transplantation 77 (2004) 760-762
74. Stallone G., Schena A., Infante B., et al. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 352 (2005) 1317-1323
75. Otley C.C., Stasko T., Tope W.D., and Lebwohl M. Chemoprevention of nonmelanoma skin cancer with systemic retinoids: practical dosing and management of adverse effects. Dermatol Surg 32 (2006) 562-568
76. Kovach B.T., Murphy G., Otley C.C., Shumack S., Ulrich C., and Stasko T. Oral retinoids for chemoprevention of skin cancers in organ transplant recipients: results of a survey. Transplant Proc 38 (2006) 1366-1368
77. Tsao H., Atkins M.B., and Sober A.J. Management of cutaneous melanoma. N Engl J Med 351 (2004) 998-1012
78. Hollenbeak C.S., Todd M.M., Billingsley E.M., Harper G., Dyer A.M., and Lengerich E.J. Increased incidence of melanoma in renal transplantation recipients. Cancer 104 (2005) 1962-1967
79. Debarbieux S., Duru G., Dalle S., Beatrix O., Balme B., and Thomas L. Sentinel lymph node biopsy in melanoma: a micromorphometric study relating to prognosis and completion lymph node dissection. Br J Dermatol 157 (2007) 58-67
80. Balch C.M., Buzaid A.C., Soong S.J., et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 19 (2001) 3635-3648
81. Greene M.H., Young T.I., and Clark Jr. W.H. Malignant melanoma in renal-transplant recipients. Lancet 1 (1981) 1196-1199
82. Le Mire L., Hollowood K., Gray D., Bordea C., and Wojnarowska F. Melanomas in renal transplant recipients. Br J Dermatol 154 (2006) 472-477
83. Leveque L., Dalac S., Dompmartin A., et al. Melanoma in organ transplant patients. Ann Dermatol Venereol 127 (2000) 160-165
84. Penn I. Malignant melanoma in organ allograft recipients. Transplantation 61 (1996) 274-278
85. NCCN. NCCN clinical practice guidelines in oncology. Melanoma V.2.2007. Available at:. http://www.nccn.org/professionals/physician_gls/PDF/melanoma.pdf Accessed September 11, 2007
86. Braun M., and Vierling J.M. The clinical and immunologic impact of using interferon and ribavirin in the immunosuppressed host. Liver Transpl 9 (2003) S79-S89
87. Baid S., Tolkoff-Rubin N., Saidman S., et al. Acute humoral rejection in hepatitis C-infected renal transplant recipients receiving antiviral therapy. Am J Transplant 3 (2003) 74-78
88. Otley C.C., Hirose R., and Salasche S.J. Skin cancer as a contraindication to organ transplantation. Am J Transplant 5 (2005) 2079-2084
89. Penn I. Transmission of cancer from organ donors. Nefrologia 15 (1995) 205-213
90. Harwood C.A., McGregor J.M., Swale V.J., et al. High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients. J Am Acad Dermatol 48 (2003) 401-408
91. Moloney F.J., Comber H., Conlon P.J., and Murphy G.M. The role of immunosuppression in the pathogenesis of basal cell carcinoma. Br J Dermatol 154 (2006) 790-791
92. Euvrard S., Kanitakis J., and Claudy A. Skin cancers after organ transplantation. N Engl J Med 348 (2003) 1681-1691
93. Rawlins J., Platt A., and Gowda P. Regression of BCC following immunosuppression withdrawal in a renal transplant recipient. Clin Exp Dermatol 31 (2006) 717-718
94. Penn I. Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transpl (1998) 147-158
95. Wijnveen A.C., Persson H., Bjorck S., and Blohme I. Disseminated Kaposi's sarcoma-full regression after withdrawal of immunosuppressive therapy: report of a case. Transplant Proc 19 (1987) 3735-3736
96. Penn I., and First M.R. Merkel's cell carcinoma in organ recipients: report of 41 cases. Transplantation 68 (1999) 1717-1721
97. Miller R.W., and Rabkin C.S. Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol Biomarkers Prev 8 (1999) 153-158
98. Kanitakis J., Euvrard S., Chouvet B., Butnaru A.C., and Claudy A. Merkel cell carcinoma in organ-transplant recipients: report of two cases with unusual histological features and literature review. J Cutan Pathol 33 (2006) 686-694
99. Akhtar S., Oza K.K., and Wright J. Merkel cell carcinoma: report of 10 cases and review of the literature. Journal of the American Academy of Dermatology 43 (2000) 755-767 [Review]
100. Buell J.F., Trofe J., Hanaway M.J., Beebe T.M., Gross T.G., Alloway R.R., First M.R., and Woodle E.S. Immunosuppression and Merkel cell cancer. Transplant Proc 34 (2002) 1780-1781
101. NCCN. NCCN clinical practice guidelines in oncology. Merkel cell carcinoma V.I.2007. Available at:. www.nccn.org/professionals/physician_gls/PDF/mcc.pdf Accessed September 11, 2007
102. Brady M.S. Current management of patients with Merkel cell carcinoma. Dermatol Surg 30 (2004) 321-325
103. Friedlaender M.M., Rubinger D., Rosenbaum E., Amir G., and Siguencia E. Temporary regression of Merkel cell carcinoma metastases after cessation of cyclosporine. Transplantation 73 (2002) 1849-1850
104. Kovach B.T., Sams H.H., and Stasko T. Multiple atypical fibroxanthomas in a cardiac transplant recipient. Dermatol Surg 31 (2005) 467-470