High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells

Annals of Biomedical Engineering

Volumn 37, Issue 6, 2009, Pages 1082-1092

  Li, Min ^a   Scott, Devon E ^a   Shandas, Robin ^a,b,c   Stenmark, Kurt R ^a   Tan, Wei ^a,b,c  

^a CHILDREN S HOSPITAL COLORADO   (United States)

^b UCB 450   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelium; Inflammation; Pulmonary hypertension; Shear stress

Indexed keywords

ADHESION MOLECULES; ARTERIAL STIFFNESS; CELLULAR MECHANISMS; CHEMOKINE; CYTOKINE; ENDOTHELIUM; FLOW FREQUENCIES; FLOW PERFUSIONS; FLOW SYSTEMS; FREQUENCY DEPENDENTS; FUNCTIONAL CHANGES; HEMODYNAMIC ENERGIES; HIGH FLOWS; INFLAMMATION; INFLAMMATORY GENES; LEUKOCYTE ADHESIONS; MICROVASCULAR; MICROVASCULAR ENDOTHELIAL CELLS; MONOCYTE ADHESIONS; MRNA EXPRESSIONS; MRNA LEVELS; PULMONARY ARTERY ENDOTHELIAL CELLS; PULMONARY HYPERTENSION; PULSATILITY; PULSATILITY INDICES; PULSE FLOWS; SELECTIN;

ADHESION; BIOACTIVITY; BLOOD VESSEL PROSTHESES; CELL MEMBRANES; CELL PROLIFERATION; GENE EXPRESSION; HYDRODYNAMICS; IMAGE STORAGE TUBES; PATHOLOGY; PULSATILE FLOW; SELF ASSEMBLY; SHEAR STRESS; STEADY FLOW; STRENGTH OF MATERIALS;

ENDOTHELIAL CELLS;

CELL ADHESION MOLECULE; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULOTROPIN A;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; CATTLE; CELL CULTURE; GENE EXPRESSION; GENETICS; MECHANICAL STRESS; METABOLISM; NEWBORN; PHYSIOLOGY; PULMONARY ARTERY; PULSATILE FLOW; TRANSCRIPTION INITIATION; UPREGULATION; VASCULAR ENDOTHELIUM;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; CATTLE; CELL ADHESION MOLECULES; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; E-SELECTIN; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PULMONARY ARTERY; PULSATILE FLOW; RNA, MESSENGER; STRESS, MECHANICAL; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 67349150059     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-009-9684-3     Document Type: Article

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