Axin localizes to the centrosome and is involved in microtubule nucleation

EMBO Reports

Volumn 10, Issue 6, 2009, Pages 606-613

  Fumoto, Katsumi ^a   Kadono, Moe ^a   Izumi, Nanae ^a   Kikuchi, Akira ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; GAMMA TUBULIN; GAMMA TUBULIN COMPLEX PROTEIN 2; NOCODAZOLE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELLULAR DISTRIBUTION; CENTROSOME; COMPLEX FORMATION; CONTROLLED STUDY; GENE OVEREXPRESSION; GOLGI COMPLEX; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

ANIMALS; CENTROSOME; HUMANS; MICE; MICROTUBULES; PROTEIN BINDING; PROTEIN TRANSPORT; REPRESSOR PROTEINS; TUBULIN;

EID: 67349132385     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.45     Document Type: Article

References (20)

1. Akhmanova A, Steinmetz MO (2008) Tracking the ends: A dynamic protein network controls the fate of microtubule tips. Nat Rev Mol Cell Biol 9: 309-322
2. Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH Jr, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI (2008) Beta-catenin is a Nek2 substrate involved in centrosome separation. Genes Dev 22: 91-105
3. Behrens J, Jerchow B-A, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl M, Wedlich D, Birchmeier W (1998) Functional interaction of an Axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280: 596-599
4. Cong F, Schweizer L, Varmus H (2004) Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development 131: 5103-5115
5. Delgehyr N, Sillibourne J, Bornens M (2005) Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function. J Cell Sci 118: 1565-1575
6. Fumoto K, Hoogenraad CC, Kikuchi A (2006) GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J 25: 5670-5682
7. Hadjihannas MV, Bruckner M, Jerchow B, Birchmeier W, Dietmaier W, Behrens J (2006) Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc Natl Acad Sci USA 103: 10747-10752
8. Izumi N, Fumoto K, Izumi S, Kikuchi A (2008) GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. J Biol Chem 283: 12981-12991
9. Kaplan DD, Meigs TE, Kelly P, Casey PJ (2004) Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem 279: 10829-10832
10. Kikuchi A (1999) Roles of Axin in the Wnt signalling pathway. Cell Signal 11: 777-788
11. Kishida S, Yamamoto H, Hino S-I, Ikeda S, Kishida M, Kikuchi A (1999) DIX domains of Dvl and Axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol 19: 4414-4422
12. Luders J, Stearns T (2007) Microtubule-organizing centres: A re-evaluation. Nat Rev Mol Cell Biol 8: 161-167
13. Lustig B et al (2002) Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22: 1184-1193
14. Mitchison TJ, Kirschner MW (1986) Isolation of mammalian centrosomes. Methods Enzymol 134: 261-268
15. Rios RM, Bornens M (2003) The Golgi apparatus at the cell centre. Curr Opin Cell Biol 15: 60-66
16. Schwarz-Romond T, Metcalfe C, Bienz M (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci 120: 2402-2412
17. Smalley MJ, Sara E, Paterson H, Naylor S, Cook D, Jayatilake H, Fryer LG, Hutchinson L, Fry MJ, Dale TC (1999) Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J 18: 2823-2835
18. Yamamoto H, Kishida S, Uochi T, Ikeda S, Koyama S, Asashima M, Kikuchi A (1998) Axil, a member of the Axin family, interacts with both glycogen synthase kinase-3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Mol Cell Biol 18: 2867-2875
19. Yamamoto H, Komekado H, Kikuchi A (2006) Caveolin is necessary for Wnt- 3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell 11: 213-223
20. Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL III, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F (1997) The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. Cell 90: 181-192