Effect of chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin in female rats on ovarian gene expression

Reproductive Toxicology

Volumn 28, Issue 1, 2009, Pages 32-37

  Valdez, Kelli E ^a,b   Shi, Zhanquan ^b   Ting, Alison Y ^a,b   Petroff, Brian K ^a,b  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Aryl hydrocarbon receptor; Menopause; Ovary; Rat

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ESTRADIOL; PROGESTERONE; STEROID 17ALPHA MONOOXYGENASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIESTRUS; DOWN REGULATION; ESTRADIOL BLOOD LEVEL; ESTROGEN SYNTHESIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENOTOXICITY; HYPOPHYSIS FUNCTION; HYPOTHALAMUS FUNCTION; LIFESPAN; LONG TERM EXPOSURE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; OVARY FUNCTION; PROGESTERONE BLOOD LEVEL; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; ESTRADIOL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GESTATIONAL AGE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARY; PREGNANCY; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; REPRODUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRACHLORODIBENZODIOXIN;

ANIMALIA; RATTUS;

EID: 67349131192     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.03.004     Document Type: Article

References (25)

1. Sharara F.I., Seifer D.B., and Flaws J.A. Environmental toxicants and female reproduction. Fertil Steril 70 (1998) 613-622
2. Geusau A., Abraham K., Geissler K., Sator M.O., Stingl G., and Tschachler E. Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects. Environ Health Perspect 109 (2001) 865-869
3. Rowlands J.C., and Gustafsson J.A. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 27 (1997) 109-134
4. Franczak A., Nynca A., Valdez K.E., Mizinga K.M., and Petroff B.K. Effects of acute and chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin on the transition to reproductive senescence in female Sprague-Dawley rats. Biol Reprod 74 (2006) 125-130
5. Gray Jr. L.E., and Ostby J.S. In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive morphology and function in female rat offspring. Toxicol Appl Pharmacol 133 (1995) 285-294
6. Petroff B.K., Roby K.F., Gao X., Son D., Williams S., Johnson D., et al. A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins in rodents. Toxicology 158 (2001) 91-107
7. Shi Z., Valdez K.E., Ting A.Y., Franczak A., Gum S.L., and Petroff B.K. Ovarian endocrine disruption underlies premature reproductive senescence following environmentally relevant chronic exposure to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Reprod 76 (2007) 198-202
8. Schecter A., Cramer P., Boggess K., Stanley J., Papke O., Olson J., et al. Intake of dioxins and related compounds from food in the U.S. population. J Toxicol Environ Health A 63 (2001) 1-18
9. Kociba R.J., Keyes D.G., Beyer J.E., Carreon R.M., Wade C.E., Dittenber D.A., et al. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 46 (1978) 279-303
10. Petroff B.K., Phillips T.A., Kimler B.F., and Fabian C.J. Detection of biomarker gene expression by real-time polymerase chain reaction using amplified ribonucleic acids from formalin-fixed random periareolar fine needle aspirates of human breast tissue. Anal Quant Cytol Histol 28 (2006) 297-302
11. al-Azzawi F. Endocrinological aspects of the menopause. Br Med Bull 48 (1992) 262-275
12. Chaffin C.L., Peterson R.E., and Hutz R.J. In utero and lactational exposure of female Holtzman rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: modulation of the estrogen signal. Biol Reprod 55 (1996) 62-67
13. Chaffin C.L., Trewin A.L., Watanabe G., Taya K., and Hutz R.J. Alterations to the pituitary-gonadal axis in the peripubertal female rat exposed in utero and through lactation to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Reprod 56 (1997) 1498-1502
14. Guo Y., Hendrickx A.G., Overstreet J.W., Dieter J., Stewart D., Tarantal A.F., et al. Endocrine biomarkers of early fetal loss in cynomolgus macaques (Macaca fascicularis) following exposure to dioxin. Biol Reprod 60 (1999) 707-713
15. Chen J.W., Wang S.L., Yu H.Y., Liao P.C., and Lee C.C. Body burden of dioxins and dioxin-like polychlorinated biphenyls in pregnant women residing in a contaminated area. Chemosphere 65 (2006) 1667-1677
16. Dey A., Jones J.E., and Nebert D.W. Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization. Biochem Pharmacol 58 (1999) 525-537
17. Dasmahapatra A.K., Wimpee B.A., Trewin A.L., and Hutz R.J. 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases steady-state estrogen receptor-beta mRNA levels after CYP1A1 and CYP1B1 induction in rat granulosa cells in vitro. Mol Cell Endocrinol 182 (2001) 39-48
18. Heimler I., Rawlins R.G., Owen H., and Hutz R.J. Dioxin perturbs, in a dose- and time-dependent fashion, steroid secretion, and induces apoptosis of human luteinized granulosa cells. Endocrinology 139 (1998) 4373-4379
19. Petroff B.K., and Mizinga K.M. Pharmacokinetics of ovarian steroids in Sprague-Dawley rats after acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Reprod Biol 3 (2003) 131-141
20. Son D.S., Ushinohama K., Gao X., Taylor C.C., Roby K.F., Rozman K.K., et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro. Reprod Toxicol 13 (1999) 521-530
21. Richards J.S., and Hedin L. Molecular aspects of hormone action in ovarian follicular development, ovulation, and luteinization. Annu Rev Physiol 50 (1988) 441-463
22. Kittappa R., Chang W.W., Awatramani R.B., and McKay R.D. The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol 5 (2007) e325
23. Bertolotti M., Gabbi C., Anzivino C., Crestani M., Mitro N., Del Puppo M., et al. Age-related changes in bile acid synthesis and hepatic nuclear receptor expression. Eur J Clin Invest 37 (2007) 501-508
24. Ho K.K., Myatt S.S., and Lam E.W. Many forks in the path: cycling with FoxO. Oncogene 27 (2008) 2300-2311
25. van der Horst A., and Burgering B.M. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 8 (2007) 440-450