Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice

Clinical and Experimental Metastasis

Volumn 26, Issue 5, 2009, Pages 415-424

  Evans, Lynda M ^a   Toline, Eric C ^b   Desmond, Renee ^c   Siegal, Gene P ^b,c,d   Hashim, Arig Ibrahim ^b   Hardy, Robert W ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Breast cancer; Dietary fat; Linoleic acid; Metastasis; Stearate; Stearic acid

Indexed keywords

CASPASE 3; LINOLEIC ACID; SAFFLOWER OIL; STEARIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; LIPID DIET; LOW FAT DIET; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; TUMOR VOLUME; WESTERN BLOTTING;

ANIMAL FEED; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; DIETARY FATS; DISEASE PROGRESSION; FEMALE; HUMANS; LINOLEIC ACID; LUNG; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; STEARATES;

EID: 67349125715     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-009-9239-x     Document Type: Article

References (32)

1. CW Welsch 1992 Relationship between dietary fat and experimental mammary tumorigenesis: a review and critique Cancer Res 52 2040s 2048s
2. MM Lee SS Lin 2000 Dietary fat and breast cancer Annu Rev Nutr 20 221 248 10.1146/annurev.nutr.20.1.221
3. DP Rose JM Connolly XH Liu 1995 Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro Nutr Cancer 24 33 45
4. DP Rose JM Connolly XH Liu 1994 Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro Cancer Res 54 6557 6562
5. DP Rose MA Hatala JM Connolly J Rayburn 1993 Effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice Cancer Res 53 4686 4690 (Pubitemid 23304401)
6. DP Rose JM Connolly J Rayburn M Coleman 1995 Influence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice J Natl Cancer Inst 87 587 592 10.1093/jnci/87.8.587
7. DP Rose JM Connolly 1993 Effects of dietary omega-3 fatty acids on human breast cancer growth and metastases in nude mice J Natl Cancer Inst 85 1743 1747 10.1093/jnci/85.21.1743 (Pubitemid 23320844)
8. SM Grundy 1994 Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids Am J Clin Nutr 60 986S 990S (Pubitemid 24371833)
9. NS Wickramasinghe H Jo JM McDonald RW Hardy 1996 Stearate inhibition of breast cancer cell proliferation. A mechanism involving epidermal growth factor receptor and G-proteins Am J Pathol 148 987 995 (Pubitemid 126660690)
10. S Hardy W El-Assaad E Przybytkowski E Joly M Prentki Y Langelier 2003 Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin J Biol Chem 278 31861 31870 10.1074/jbc.M300190200
11. RK Singh RW Hardy MH Wang J Williford CL Gladson JM McDonald GP Siegal 1995 Stearate inhibits human tumor cell invasion Invasion Metastasis 15 144 155 (Pubitemid 26098002)
12. IJ Tinsley JA Schmitz DA Pierce 1981 Influence of dietary fatty acids on the incidence of mammary tumors in the C3H mouse Cancer Res 41 1460 1465 (Pubitemid 11146782)
13. AS Bennett 1984 Effect of dietary stearic acid on the genesis of spontaneous mammary adenocarcinomas in strain A/ST mice Int J Cancer 34 529 533 10.1002/ijc.2910340416 (Pubitemid 14014120)
14. NA Habib CB Wood K Apostolov W Barker MJ Hershman M Aslam D Heinemann B Fermor RC Williamson WE Jenkins 1987 Stearic acid and carcinogenesis Br J Cancer 56 455 458 (Pubitemid 17146350)
15. DR Welch 2006 Do we need to redefine a cancer metastasis and staging definitions? Breast Dis 26 3 12 (Pubitemid 46647411)
16. PS Steeg 2006 Tumor metastasis: mechanistic insights and clinical challenges Nat Med 12 895 904 10.1038/nm1469
17. AA Spector JC Hoak 1969 An improved method for the addition of long-chain free fatty acid to protein solutions Anal Biochem 32 297 302 10.1016/0003-2697(69)90089-X
18. JE Price A Polyzos RD Zhang LM Daniels 1990 Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice Cancer Res 50 717 721 (Pubitemid 20054204)
19. BF Fermor JR Masters CB Wood J Miller K Apostolov NA Habib 1992 Fatty acid composition of normal and malignant cells and cytotoxicity of stearic, oleic and sterculic acids in vitro Eur J Cancer 28A 1143 1147 10.1016/0959-8049(92)90475-H
20. DP Rose JM Connolly 2000 Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids Nutr Cancer 37 119 127 10.1207/S15327914NC372-1
21. RE Harris FM Robertson HM Abou-Issa WB Farrar R Brueggemeier 1999 Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer Med Hypotheses 52 291 292 10.1054/mehy.1998.0009
22. JM Connolly XH Liu DP Rose 1996 Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor Nutr Cancer 25 231 240 (Pubitemid 26176126)
23. J Chen PM Stavro LU Thompson 2002 Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor Nutr Cancer 43 187 192 10.1207/S15327914NC432-9 (Pubitemid 36134093)
24. WE Hardman L Sun N Short IL Cameron 2005 Dietary omega-3 fatty acids and ionizing irradiation on human breast cancer xenograft growth and angiogenesis Cancer Cell Int 5 12 10.1186/1475-2867-5-12
25. WE Hardman 2007 Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice Nutr Cancer 57 177 183 (Pubitemid 47080090)
26. Y Fujimoto T Yonemura S Sakuma 2008 Stearic acid potently modulates the activity of cyclooxygenase-1, but not cyclooxygenase-2, in the form of its CoA ester Prostaglandins Leukot Essent Fatty Acids 78 81 84 10.1016/j.plefa.2007.10. 029
27. Artwohl M, Lindenmair A, Sexl V, Maier C, Rainer G, Freudenthaler A, Huttary N, Wolzt M, Nowotny P, Luger A and Baumgartner-Parzer SM (2008) Different mechanisms of saturated versus polyunsaturated free fatty acid-induced apoptosis in human endothelial cells. J Lipid Res
28. M Artwohl M Roden W Waldhausl A Freudenthaler SM Baumgartner-Parzer 2004 Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular endothelial cells FASEB J 18 146 148
29. HR MacDonald RK Lees C Bron B Sordat G Miescher 1987 T cell antigen receptor expression in athymic (nu/nu) mice. Evidence for an oligoclonal beta chain repertoire J Exp Med 166 195 209 10.1084/jem.166.1.195
30. JE Talmadge M Donkor E Scholar 2007 Inflammatory cell infiltration of tumors: Jekyll or Hyde Cancer Metastasis Rev 26 373 400 10.1007/s10555-007-9072- 0
31. TM Lima CC Kanunfre C Pompeia R Verlengia R Curi 2002 Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis Toxicol in vitro 16 741 747 10.1016/S0887-2333(02)00095-4
32. NM Jeffery P Sanderson EA Newsholme PC Calder 1997 Effects of varying the type of saturated fatty acid in the rat diet upon serum lipid levels and spleen lymphocyte functions Biochim Biophys Acta 1345 223 236 (Pubitemid 27171200)