Does dexmedetomidine reduce secondary damage after spinal cord injury? An experimental study

European Spine Journal

Volumn 18, Issue 3, 2009, Pages 336-344

  Aslan, Adem ^a   Cemek, Mustafa ^a   Eser, Olcay ^a   Altunbaş, Korhan ^a   Buyukokuroglu, Mehmet Emin ^a   Cosar, Murat ^a   Baş, Orhan ^a   Ela, Yuksel ^a   Fidan, Huseyin ^a  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Dexmedetomidine; Neuroprotection; Oxidative stress; Spinal cord injury

Indexed keywords

DEXMEDETOMIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CEREBROSPINAL FLUID; CONTROL GROUP; CONTROLLED STUDY; EXPERIMENTAL ANIMAL; EXPERIMENTAL STUDY; FEMALE; LAMINECTOMY; LIPID PEROXIDATION; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; SPINAL CORD INJURY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; DEXMEDETOMIDINE; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENERGY METABOLISM; FEMALE; LIPID PEROXIDATION; MALE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PARAPLEGIA; RABBITS; SPINAL CORD; SPINAL CORD INJURIES; TREATMENT FAILURE;

EID: 67349118481     PISSN: 09406719     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00586-008-0872-x     Document Type: Article

References (37)

1. H Aebi 1984 Catalase in vitro Methods Enzymol 105 121 126 10.1016/S0076-6879(84)05016-3
2. DK Anderson ED Hall 1993 Pathophysiology of spinal cord trauma Ann Emerg Med 22 987 992 10.1016/S0196-0644(05)82739-8
3. O Ates SR Cayli E Altinoz I Gurses N Yucel A Kocak S Yologlu Y Turkoz 2006 Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury Acta Pharmacol Sin 27 1317 1325 10.1111/j.1745-7254.2006.00416.x
4. O Ates SR Cayli I Gurses Y Turkoz O Tarim CO Cakir A Kocak 2007 Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury J Clin Neurosci 14 658 665 10.1016/j.jocn.2006.03.023
5. RD Azbill X Mu AJ Bruce-Keller MP Mattson JE Springer 1997 Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury Brain Res 765 283 290 10.1016/S0006-8993(97)00573-8
6. B Blanchard D Pompon C Ducrocq 2000 Nitrosation of melatonin by nitric oxide and peroxynitrite J Pineal Res 29 184 192 10.1034/j.1600-079X.2000.290308. x
7. E Beutler O Dubon BM Kelly 1963 Improved method for the determination of blood glutathione J Lab Clin Med 6 882 888
8. SR Cayli O Ates N Karadag E Altinoz N Yucel S Yologlu A Kocak CO Cakir 2006 Neuroprotective effect of etomidate on functional recovery in experimental spinal cord injury Int J Dev Neurosci 24 233 239 10.1016/j.ijdevneu.2006.04.003
9. JR Cormack RM Orme TG Costello 2005 The role of a2-agonists in neurosurgery J Clin Neurosci 12 375 378 10.1016/j.jocn.2004.06.008
10. M Cosar O Eser H Fidan O Sahin S Buyukbas Y Ela M Yagmurca OA Ozen 2009 The neuroprotective effect of dexmedetomidine in the hippocampus of rabbits after subarachnoid hemorrhage Surg Neurol 71 54 59
11. MG Fehlings DC Baptiste 2005 Current status of clinical trials for acute spinal cord injury Injury 36 113 122 10.1016/j.injury.2005.06.022
12. L Flohe F Otting 1984 Superoxide dismutase assays Methods Enzymol 105 93 104 10.1016/S0076-6879(84)05013-8
13. KY Ha YH Kim KW Rhyu SE Kwon 2008 Pregabalin as a neuroprotector after spinal cord injury in rats Eur Spine J 17 864 872 10.1007/s00586-008-0653-6
14. ED Hall 1993 Lipid peroxidants in acute central nervous system injury Ann Emerg Med 22 1022 1027 10.1016/S0196-0644(05)82745-3
15. K Hayashi N Noguchi E Niki 1995 Action of nitric oxide as an antioxidant against oxidation of soybean phosphatidylcholine liposomal membranes FEBS Lett 370 37 40 10.1016/0014-5793(95)00786-9
16. SK Jain R McVie J Duett JJ Herbst 1989 Erythrocyte membrane lipid peroxidase and glycolylated hemoglobin in diabetes Diabetes 38 1539 1543 10.2337/diabetes.38.12.1539
17. EL Janke S Sarma 2006 Dexmedetomidine and neuroprotection. Seminars in Anesthesia Perioper Med Pain 25 71 76 10.1053/j.sane.2006.02.002
18. W Jessup D Mohr SP Gieseg RT Dean R Stocker 1992 The participation of nitric oxide in cell free and its restriction of macrophage-mediated oxidation of low-density lipoprotein Biochim Biophys Acta 1180 73 82
19. M Kanter O Coskun M Kalayci S Buyukbas F Cagavi 2006 Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats Hum Exp Toxicol 25 127 133 10.1191/0960327106ht608oa
20. MY Kaynar M Hanci C Kuday A Belce K Gumustas E Kokoglu 1994 Changes in the activity of antioxidant enzymes (SOD, GPX, CAT) after experimental spinal cord injury Tokushima J Exp Med 41 133 136
21. M Kurihara 1985 Role of monoamines in experimental spinal cord injury in rats. Relationship between Na + -K + -ATPase and lipid peroxidation J Neurosurg 62 743 749
22. JB Liu TS Tang HL Yang 2006 Antioxidation of quercetin against spinal cord injury in rats Chin J Traumatol 9 303 307
23. D Ma M Hossain N Rajakumaraswamy M Arshad RD Sanders NP Franks M Maze 2004 Dexmedetomidine produces its neuroprotective effect via the alpha 2A-adrenoceptor subtype Eur J Pharmacol 11 87 97 10.1016/j.ejphar.2004.08.044
24. KM Miranda MG Espey DA Wink 2001 A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite Nitric Oxide 5 62 71 10.1006/niox.2000.0319
25. MR Nogues M Giralt M Romeu M Mulero V Sanchez-Martos E Rodriguez D Acuna-Castroviejo J Mallol 2006 Melatonin reduces oxidative stress in erythrocytes and plasma of senescence-accelerated mice J Pineal Res 41 142 149 10.1111/j.1600-079X.2006.00344.x
26. Omaye ST, Turnbul JD, Savberlich HE (1979) Ascorbic acid analysis II. Determination after derivatisation with 2.2. dinitrophenylhidrazine. Selected methods for determination of ascorbic acid in animal cells tissues and fluids. In: McCormick DB, Wright LD (eds) Methods in Enzymology, vol 62. Academic Press, New York, pp 7-8
27. M Ozdemir SL Cengiz M Gurbilek TC Ogun ME Ustun 2005 Effects of magnesium sulfate on spinal cord tissue lactate and malondialdehyde levels after spinal cord trauma Magnes Res 18 170 174
28. DE Paglia WN Valentine 1967 Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase J Lab Clin Med 70 158 169
29. JC Papakostas MI Matsagas IK Toumpoulis VD Malamou-Mitsi LS Papa C Gkrepi CE Anagnostopoulos AM Kappas 2006 Evolution of spinal cord injury in a porcine model of prolonged aortic occlusion J Surg Res 133 159 166 10.1016/j.jss.2005. 10.007
30. A Paris J Mantz PH Tonner L Hein M Brede P Gressens 2006 The effects of dexmedetomidine on perinatal excitotoxic brain injury are mediated by the alpha2A-adrenoceptor subtype Anesth Analg 102 456 461 10.1213/01.ane.0000194301. 79118.e9
31. S Samantaray EA Sribnick A Das VH Knaryan DD Matzelle AV Yallapragada RJ Reiter SK Ray NL Banik 2007 Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats J Pineal Res 44 348 357 10.1111/j.1600-079X.2007.00534.x
32. I Suzuki N Katoh 1990 A simple and cheap method for measuring serum vitamin A in cattle using spectrophototmeter Jpn J Vet Sci 52 1281 1283
33. CH Tator MG Fehlings 1991 Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms J Neurosurg 75 15 26
34. S Taysi M Koc ME Buyukokuroglu K Altinkaynak YN Sahin 2003 Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver J Pineal Res 34 173 177 10.1034/j.1600-079X.2003.00024. x
35. MD Tsifansky CG Schmitt RA Muñoz 2007 Dexmedetomidine: do we know enough? Pediatr Crit Care Med 8 492 493
36. S Tsutsumi T Ueta K Shiba 2006 Effects of the Second National Acute Spinal Cord Injury Study of high-dose methylprednisolone therapy on acute cervical spinal cord injury-results in spinal injuries center Spine 31 2992 2997 10.1097/01.brs.0000250273.28483.5c
37. S Yoshino K Yone 1998 Role of norepinephrine and excitatory amino acids in edema of the spinal cord after experimental compression injury in rats J Orthop Sci 3 54 59 10.1007/s007760050021