Synthesis and pharmacological investigation of novel 4-(2-methylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-o nes as new class of H1-antihistaminic agents

European Journal of Medicinal Chemistry

Volumn 43, Issue 11, 2008, Pages 2331-2337

  Alagarsamy, V ^a   Rupeshkumar, M ^b   Kavitha, K ^b   Meena, S ^c   Shankar, D ^c   Siddiqui, A A ^d   Rajesh, R ^d  

^a Kumarswamy Layout   (India)

^b BHARATHI COLLEGE OF PHARMACY   (India)

^c K M COLLEGE OF PHARMACY   (India)

^d HAMDARD UNIVERSITY   (India)

Author keywords

H1 antihistaminic agents; Quinazolin 5 ones; Sedation; Triazoles; Triazoloquinazolines

Indexed keywords

1 METHYL 4 (2 METHYLPHENYL) 4H [1,2,4]TRIAZOLO[4,3 ALPHA]QUINAZOLIN 5 ONE; 4 (2 METHYLPHENYL) 1 4H [1,2,4]TRIAZOLO[4,3 ALPHA]QUINAZOLIN 5 ONE; ANTIHISTAMINIC AGENT; CHLORPHENIRAMINE MALEATE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; MOUSE; NONHUMAN; SEDATION;

ANIMALS; CENTRAL NERVOUS SYSTEM; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; MALE; METHYLATION; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 54249105961     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.10.001     Document Type: Article

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