Genome-wide association analysis in domestic animals: A powerful approach for genetic dissection of trait loci

Genetica

Volumn 136, Issue 2, 2009, Pages 341-349

  Andersson, Leif ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Domestic animals; Genome wide association analysis; MITF; QTL; Selection

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; BREEDING; DOMESTIC ANIMAL; GENETIC ASSOCIATION; GENETICS; HISTOLOGY; HUMAN; METHODOLOGY; MUTATION; QUANTITATIVE TRAIT LOCUS;

ANIMALS; ANIMALS, DOMESTIC; BREEDING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MUTATION; QUANTITATIVE TRAIT LOCI;

ANIMALIA; CANIS FAMILIARIS;

EID: 67349112823     PISSN: 00166707     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10709-008-9312-4     Document Type: Article

References (27)

1. L Andersson M Georges 2004 Domestic animal genomics: deciphering the genetics of complex traits Nat Rev Genet 5 202 212 10.1038/nrg1294
2. BR Barnes S Marklund TL Steiler 2004 The AMPK-gamma3 isoform has a key role for carbohydrate and lipid metabolism in glycolytic skeletal muscle J Biol Chem 279 38441 38447 10.1074/jbc.M405533200
3. D Ciobanu J Bastiaansen M Malek 2001 Evidence for new alleles in the protein kinase adenosine monophosphate-activated γ3-subunit gene associated with low glycogen content in pig skeletal muscle and improved meat quality Genetics 159 1151 1162
4. A Clop F Marcq H Takeda 2006 A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep Nat Genet 38 813 818 10.1038/ng1810
5. J Fujii K Otsu F Zorzato 1991 Identification of a mutation in the porcine ryanodine receptor that is associated with malignant hyperthermia Science 253 448 451 10.1126/science.1862346
6. E Giuffra A Törnsten S Marklund 2002 A large duplication associated with Dominant White color in pigs originated by homologous recombination between LINE elements flanking KIT Mamm Genome 13 569 577 10.1007/s00335-002-2184-5
7. B Grisart W Coppieters F Farnir 2002 Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition Genome Res 12 222 231 10.1101/gr.224202
8. B Grisart F Farnir L Karim 2004 Genetic and functional demonstration of the causality of the DGAT1 K232A mutation in the determinism of the BTA14 QTL affecting milk yield and composition Proc Natl Acad Sci USA 101 2398 2403 10.1073/pnas.0308518100
9. M Johansson H Ellegren L Marklund 1992 The gene for dominant white color in the pig is closely linked to ALB and PDGFRA on chromosome 8 Genomics 14 965 969 10.1016/S0888-7543(05)80118-1
10. M Johansson Moller R Chaudhary E Hellmen 1996 Pigs with the dominant white coat color phenotype carry a duplication of the KIT gene encoding the mast/stem cell growth factor receptor Mamm Genome 7 822 830 10.1007/ s003359900244
11. EK Karlsson I Baranowska CM Wade 2007 Efficient mapping of Mendelian traits in dogs through genome-wide association analysis Nat Genet 39 1321 1328 10.1038/ng.2007.10
12. S Kerje P Sharma U Gunnarsson 2004 The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene Genetics 168 1507 1518 10.1534/genetics.104.027995
13. JMH Kijas R Wales A Törnsten 1998 Melanocortin receptor 1 (MC1R) mutations and coat color in pigs Genetics 150 1177 1185
14. JMH Kijas M Moller G Plastow 2001 A frameshift mutation in MC1R and a high frequency of somatic reversions cause black spotting in pigs Genetics 158 779 785
15. MC King AC Wilson 1975 Evolution at two levels in humans and chimpanzees Science 188 107 116 10.1126/science.1090005
16. K Lindblad-Toh CM Wade TS Mikkelsen 2005 Genome sequence, comparative analysis and haplotype structure of the domestic dog Nature 438 803 819 10.1038/nature04338
17. Little CC (1957) The inheritance of coat colour in the dogs. Cornell University Press, Ithaca
18. TFC Mackay 2001 Quantitative trait loci in Drosophila Nat Rev Genet 2 11 21 10.1038/35047544
19. S Marklund J Kijas H Rodriguez-Martinez 1998 Molecular basis for the dominant white phenotype in the domestic pig Genome Res 8 826 833
20. D Milan JT Jeon C Looft 2000 A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle Science 288 1248 1251 10.1126/science.288.5469.1248
21. MV Olson 1999 When less is more: gene loss as an engine of evolutionary change Am J Hum Genet 64 18 23 10.1086/302219
22. G Pielberg C Olsson A-C Syvänen 2002 Unexpectedly high allelic diversity at the KIT locus causing dominant white color in the domestic pig Genetics 160 305 311
23. NHC Salmon Hillbertz M Isaksson EK Karlsson 2007 A duplication of FGF3, FGF4, FGF9 and ORAOV1 causes the hair ridge and predisposes to dermoid sinus in Ridgeback dogs Nat Genet 38 1318 1320 10.1038/ng.2007.4
24. E Steingrimsson NG Copeland NA Jenkins 2004 Melanocytes and the microphthalmia transcription factor network Annu Rev Genet 38 365 411 10.1146/annurev.genet.38.072902.092717
25. A Theos S Truschel G Raposo 2005 The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function Pigment Cell Res 18 322 336 10.1111/j.1600-0749.2005.00269.x
26. AS Van Laere M Nguyen M Braunschweig 2003 Positional identification of a regulatory mutation in IGF2 causing a major QTL effect on muscle growth in the pig Nature 425 832 836 10.1038/nature02064
27. A Winter W Kramer FA Werner 2002 Association of a lysine-232/alanine polymorphism in a bovine gene encoding acyl-CoA:diacylglycerol acyltransferase (DGAT1) with variation at a quantitative trait locus for milk fat content Proc Natl Acad Sci USA 99 9300 9305 10.1073/pnas.142293799