Trypanosoma cruzi maxicircle heterogeneity in Chagas disease patients from Brazil

International Journal for Parasitology

Volumn 39, Issue 9, 2009, Pages 963-973

  Carranza, Julio César ^a   Valadares, Helder M S ^b   D'Ávila, Daniella A ^b   Baptista, Rodrigo P ^b   Moreno, Margoth ^a   Galvão, Lúcia M C ^b,c   Chiari, Egler ^b   Sturm, Nancy R ^d   Gontijo, Eliane D ^b   Macedo, Andrea M ^b   Zingales, Bianca ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chagas disease; Clinical presentations; Microsatellites; Mitochondrial complex I; NADH dehydrogenase subunit 7

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

DISEASE SEVERITY; GENETIC ANALYSIS; GENOTYPE; HETEROGENEITY; INFECTIOUS DISEASE; INFECTIVITY; LESION; MITOCHONDRIAL DNA;

ADULT; ARGENTINA; ARTICLE; BOLIVIA; BRAZIL; CARDIOMYOPATHY; CHAGAS DISEASE; CHILE; CLADISTICS; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DIGESTIVE SYSTEM INJURY; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBUNIT; FEMALE; GENE CLUSTER; GENE DELETION; GENE MUTATION; GENETIC HETEROGENEITY; GENOTYPE; HEART INJURY; HOST PARASITE INTERACTION; HUMAN; HYBRID; IMMUNOGENETICS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREVALENCE; PROTOZOAL GENETICS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; STRAIN DIFFERENCE; TRYPANOSOMA CRUZI; WILD TYPE;

ANIMALS; BRAZIL; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; GENE EXPRESSION PROFILING; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NADH DEHYDROGENASE; PROTOZOAN PROTEINS; TRYPANOSOMA CRUZI;

ARGENTINA; BOLIVIA; BRAZIL; CHILE; SOUTH AMERICA;

TRYPANOSOMA CRUZI;

EID: 67349109158     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2009.01.009     Document Type: Article

References (61)

1. Abel L.C., Rizzo L.V., Ianni B., Albuquerque F., Bacal F., Carrara D., Bocchi E.A., Teixeira H.C., Mady C., Kalil J., and Cunha-Neto E. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection. J. Autoimmun. 17 (2001) 99-107
2. Alves A.M., Almeida D.F., and von Krüger W.M. Changes in Trypanosoma cruzi kinetoplast DNA minicircles induced by environmental conditions and subcloning. J. Eukaryot. Microbiol. 41 (1994) 415-419
3. Añez N., Crisante G., da Silva F.M., Rojas A., Carrasco H., Umezawa E.S., Stolf A.M., Ramírez J.L., and Teixeira M.M. Predominance of lineage I among Trypanosoma cruzi isolates from Venezuelan patients with different clinical profiles of acute Chagas' disease. Trop. Med. Int. Health 9 (2004) 1319-1326
4. Anonymous. Recommendations from a satellite meeting. Mem. Inst. Oswaldo Cruz 94 Suppl. 1 (1999) 429-432
5. Augusto-Pinto L., Teixeira S.M., Pena S.D., and Machado C.R. Single-nucleotide polymorphisms of the Trypanosoma cruzi MSH2 gene support the existence of three phylogenetic lineages presenting differences in mismatch-repair efficiency. Genetics 164 (2003) 117-126
6. Baptista C.S., Vêncio R.Z., Abdala S., Carranza J.C., Westenberger S.J., Silva M.N., Pereira C.A., Galvão L.M., Gontijo E.D., Chiari E., Sturm N.R., and Zingales B. Differential transcription profiles in Trypanosoma cruzi associated with clinical forms of Chagas disease: Maxicircle NADH dehydrogenase subunit 7 gene truncation in asymptomatic patient isolates. Mol. Biochem. Parasitol. 150 (2006) 236-248
7. Brenière S.F., Bosseno M.F., Telleria J., Bastrenta B., Yacsik N., Noireau F., Alcazar J.L., Barnabé C., Wincker P., and Tibayrenc M. Different behavior of two Trypanosoma cruzi major clones: transmission and circulation in young Bolivian patients. Exp. Parasitol. 89 (1998) 285-295
8. Brenière S.F., Carrasco R., Revollo S., Aparicio G., Desjeux P., and Tibayrenc M. Chagas' disease in Bolivia: clinical and epidemiological features and zymodeme variability of Trypanosoma cruzi strains isolated from patients. Am. J. Trop. Med. Hyg. 41 (1989) 521-529
9. Brisse S., Barnabé C., and Tibayrenc M. Identification of six Trypanosoma cruzi phylogenetic lineages by random amplified polymorphic DNA and multilocus enzyme electroforesis. Int. J. Parasitol. 30 (2000) 35-44
10. Brisse S., Verhoef J., and Tibayrenc M. Characterisation of large and small subunit rRNA and mini-exon genes further supports the distinction of six Trypanosoma cruzi lineages. Int. J. Parasitol. 31 (2001) 1218-1226
11. Burgos J.M., Altcheh J., Bisio M., Duffy T., Valadares H.M., Seidenstein M.E., Piccinali R., Freitas J.M., Levin M.J., Macchi L., Macedo A.M., Freilij H., and Schijman A.G. Direct molecular profiling of minicircle signatures and lineages of Trypanosoma cruzi bloodstream populations causing congenital Chagas disease. Int. J. Parasitol. 37 (2007) 1319-1327
12. Burgos J.M., Begher S., Freitas J.M., Bisio M., Duffy T., Altcheh J., Teijeiro R., Lopez Alcoba H., Deccarlini F., Freilij H., Levin M.J., Levalle J., Macedo A.M., and Schijman A.G. Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas disease in a patient with AIDS. Am. J. Trop. Med. Hyg. 73 (2005) 1016-1018
13. Burgos J.M., Begher S., Valadares Silva H.M., Bisio M., Duffy T., Levin M.J., Macedo A.M., and Schijman A.G. Case report: molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS. Am. J. Trop. Med. Hyg. 78 (2008) 294-297
14. Campbell D.A., Westenberger S.J., and Sturm N.R. The determinants of Chagas disease: connecting parasite and host genetics. Curr. Mol. Med. 4 (2004) 549-562
15. Chiari E., Dias J., Lana M., and Chiari C. Hemocultures for the parasitological diagnosis of human chronic Chagas' disease. Rev. Soc. Bras. Med. Trop. 22 (1989) 19-23
16. Consenso Brasileiro em Doença de Chagas. Secretaria de Vigilância em Saúde do Ministério da Saúde., 2005. Rev. Soc. Bras. Med. Trop. 38 (Supl. III).
17. Coura J.R., Borges-Pereira J., and Araujo R.M. Morbidity and regional variation of Chagas disease in Brazil. Mem. Inst. Oswaldo Cruz 94 Suppl. II (1999) 26-27
18. Coura J.R., Junqueira A.C., Fernandes O., Valente S.A., and Miles M.A. Emerging Chagas disease in Amazonian Brazil. Trends Parasitol. 18 (2002) 171-176
19. D'Ávila D.A., Gontijo E.D., Lages-Silva E., Meira W.S.F., Chiari E., and Galvão L.M.C. Random amplified polymorphic DNA profiles of Trypanosoma cruzi isolates from chagasic patients with different clinical forms. Parasitol. Res. 98 (2006) 455-461
20. Deghaide N.H., Dantas R.O., and Donadi E.A. HLA class I and II profiles of patients presenting with Chagas' disease. Dig. Dis. Sci. 43 (1998) 246-252
21. Dias J.C.P. Epidemiology of Chagas disease. In: Wendel S., Brener Z., Camargo M., and Rassi A. (Eds). Chagas Disease (American Trypanosomiasis): Its Impact on Transfusion and Clinical Medicine (1992), ISBT, Brazil'92, São Paulo 49-80
22. Dias J.C.P. The treatment of Chagas disease (South American trypanosomiasis). Ann. Intern. Med. 144 (2006) 772-774
23. Doublet V., Souty-Grosset C., Bouchon D., Cordaux R., and Marcadé R. A thirty million year-old inherited heteroplasmy. PLoS ONE 3 (2008) e2938
24. Faé K.C., Drigo S.A., Cunha-Neto E., Ianni B., Mady C., Kalil J., and Goldberg A.C. HLA and beta-myosin heavy chain do not influence susceptibility to Chagas disease cardiomyopathy. Microbes Infect. 2 (2000) 745-751
25. Fernandes O., Santos S.S., Cupolillo E., Mendonça B., Derré R., Junqueira A.C., Santos L.C., Sturm N.R., Naiff R.D., Barrett T.V., Campbell D.A., and Coura J.R. Trypanosomiasis in the Brazilian Amazon - a mini-exon multiplex PCR to distinguish the major groups of Trypanosoma cruzi and Trypanosoma rangeli. Trans. R. Soc. Trop. Med. Hyg. 95 (2001) 1-3
26. Fernandes O., Sturm N.R., Derré R., and Campbell D.A. The mini-exon gene: a genetic marker for zymodeme III of Trypanosoma cruzi. Mol. Biochem. Parasitol. 95 (1998) 129-133
27. Freitas J., Augusto-Pinto L., Pimenta J., Bastos-Rodrigues L., Gonçalves V., Teixeira S., Chiari E., Junqueira A., Fernandes O., Macedo A., Machado C., and Pena S. Ancestral genomes, sex, and the population structure of Trypanosoma cruzi. PLoS Pathogens 2 (2006) 226-235
28. Freitas J.M., Lages-Silva E., Crema E., Pena S.D., and Macedo A.M. Real time PCR strategy for the identification of major lineages of Trypanosoma cruzi directly in chronically infected human tissues. Int. J. Parasitol. 35 (2005) 411-417
29. Gaunt M.W., Yeo M., Frame I.A., Stothard J.R., Carrasco H.J., Taylor M.C., Mena S.S., Veazey P., Miles G.A., Acosta N., de Arias A.R., and Miles M.A. Mechanism of genetic exchange in American trypanosomes. Nature 421 (2003) 936-939
30. Gomes J.A., Bahia-Oliveira L.M., Rocha M.O., Martins-Filho O.A., Gazzinelli G., and Correa-Oliveira R. Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infect. Immun. 71 (2003) 1185-1193
31. Herrera C., Bargues M.D., Fajardo A., Montilla M., Triana O., Vallejo G.A., and Guhl F. Identifying four Trypanosoma cruzi I isolate haplotypes from different geographic regions in Colombia. Infect. Genet. Evol. 7 (2007) 535-539
32. Lages-Silva E., Ramírez L.E., Pedrosa A.L., Crema L., Galvão L.M.C., Pena S.D.J., Macedo A.M., and Chiari E. Variability of kinetoplast DNA gene signatures of Trypanosoma cruzi II strains from patients with different clinical forms of Chagas' disease in Brazil. J. Clin. Microbiol. 44 (2006) 2167-2171
33. Luquetti A.O., Miles M.A., Rassi A., de Rezende J.M., de Souza A.A., Póvoa M.M., and Rodrigues I. Trypanosoma cruzi: zymodemes associated with acute and chronic Chagas' disease in central Brazil. Trans. R. Soc. Trop. Med. Hyg. 80 (1986) 462-470
34. Macedo A.M., Machado C., Oliveira R., and Pena S. Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of Chagas disease. Mem. Inst. Oswaldo Cruz 99 (2004) 1-12
35. Macedo A.M., Martins M., Chiari E., and Pena S. DNA fingerprinting of Trypanosoma cruzi: a new tool for characterization of strains and clones. Mol. Biochem. Parasitol. 55 (1992) 147-154
36. Macedo A.M., Pimenta J.R., Aguiar R.S., Melo A.I.R., Chiari E., Zingales B., Pena S.D., and Oliveira R.P. Usefulness of microsatellite typing in population genetic studies of Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz 96 (2001) 407-413
37. Machado C.A., and Ayala F.J. Nucleotide sequences provide evidence of genetic exchange among distantly related lineages of Trypanosoma cruzi. Proc. Natl. Acad. Sci. USA 98 (2001) 7396-7401
38. Mendonça M.B., Nehme N.S., Santos S.S., Cupolillo E., Vargas N., Junqueira A., Naiff R.D., Barrett T.V., Coura J.R., Zingales B., and Fernandes O. Two main clusters within Trypanosoma cruzi zymodeme 3 are defined by distinct regions of the ribosomal RNA cistron. Parasitology 124 (2002) 177-184
39. Miles M.A., Lanham S.M., de Souza A.A., and Póvoa M. Further enzymic characters of Trypanosoma cruzi and their evaluation for strain identification. Trans. R. Soc. Trop. Med. Hyg. 74 (1980) 221-242
40. Miles M.A., Souza A., Povoa M., Shaw J.J., Lainson R., and Toye P.J. Isozymic heterogeneity of Trypanosoma cruzi in the first autochthonous patients with Chagas' disease in Amazonian Brazil. Nature 272 (1978) 819-821
41. Nicholas, K.B., Nicholas, H.B.J., Deerfield, D.W., 1997. GeneDoc: Analysis and Visualization of Genetic Variation. EMBNEW. NEWS 4, 14.
42. Oliveira R.P., Broude N.E., Macedo A.M., Cantor C.R., Smith C.L., and Pena S.D. Probing the genetic population structure of Trypanosoma cruzi with polymorphic microsatellites. Proc. Natl. Acad. Sci. USA 95 (1998) 3776-3780
43. Oliveira R.P., Melo A.I.R., Macedo A.M., Chiari E., and Pena S.D.J. The population structure of Trypanosoma cruzi: expanded analysis of 54 strains using eight polymorphic CA-repeat microsatellites. Mem. Inst. Oswaldo Cruz 94 (1999) 65-70
44. Opperdoes F., and Michels P. Complex I of Trypanosomatidae: does it exist?. Trends Parasitol. 24 (2008) 310-317
45. Ramasawmy R., Cunha-Neto E., Faé K.C., Müller N.G., Cavalcanti V.L., Drigo S.A., Ianni B., Mady C., Kalil J., and Goldberg A.C. BAT1, a putative anti-inflammatory gene, is associated with chronic Chagas cardiomyopathy. J. Infect. Dis. 193 (2006) 1394-1399
46. Ramasawmy R., Faé K.C., Cunha-Neto E., Müller N.G., Cavalcanti V.L., Ferreira R.C., Drigo S.A., Ianni B., Mady C., Goldberg A.C., and Kalil J. Polymorphisms in the gene for lymphotoxin-predispose to chronic Chagas cardiomyopathy. J. Infect. Dis. 196 (2007) 1837-1843
47. Reis D.D., Jones E.M., Tostes Jr. S., Lopes E.R., Gazzinelli G., Colley D.G., and McCurley T.L. Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes. Am. J. Trop. Med. Hyg. 48 (1993) 637-644
48. Simpson L., Neckelmann N., de la Cruz V.F., Simpson A.M., Feagin J.E., Jasmer D.P., and Stuart J.E. Comparison of the maxicircle (mitochondrial) genomes of Leishmania tarentolae and Trypanosoma brucei at the level of nucleotide sequence. J. Biol. Chem. 262 (1987) 6182-6196
49. Solari A., Campillay R., Ortíz S., and Wallace A. Identification of Trypanosoma cruzi genotypes circulating in Chilean chagasic patients. Exp. Parasitol. 97 (2001) 226-233
50. Souto R.P., Fernandes O., Macedo A.M., Campbell D.A., and Zingales B. DNA markers define two major phylogenetic lineages of Trypanosoma cruzi. Mol. Biochem. Parasitol. 83 (1996) 141-152
51. Souto R.P., and Zingales B. Sensitive detection and strain classification of Trypanosoma cruzi by amplification of a ribosomal RNA sequence. Mol. Biochem. Parasitol. 62 (1993) 45-52
52. Talvani A., Rocha M.O., Barcelos L.S., Gomes Y.M., Ribeiro A.L., and Teixeira M.M. Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy. Clin. Infect. Dis. 38 (2004) 943-950
53. Tibayrenc M., and Ayala F.J. The clonal theory of parasitic protozoa: 12 years on. Trends Parasitol. 18 (2002) 405-410
54. Tibayrenc M., and Ayala F.J. Isoenzyme variability in Trypanosoma cruzi, the agent of Chagas disease: genetical, taxonomic and epidemiological significance. Evolution 42 (1988) 277-292
55. Vago A.R., Andrade L.O., Leite A.A., d'Avila Reis D., Macedo A.M., Adad S.J., Tostes Jr. S., Moreira M.C., Filho G.B., and Pena S.D.J. Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organs. Am. J. Pathol. 156 (2000) 1805-1809
56. Valadares H.M., Pimenta J.R., de Freitas J.M., Duffy T., Bartholomeu D.C., Oliveira R.d.P., Chiari E., Moreira M.C., Filho G.B., Schijman A.G., Franco G.R., Machado C.R., Pena S.D., and Macedo A.M. Genetic profiling of Trypanosoma cruzi directly in infected tissues using nested PCR of polymorphic microsatellites. Int. J. Parasitol. 38 (2008) 839-850
57. Westenberger S.J., Barnabé C., Campbell D.A., and Sturm N.R. Two hybridization events define the population structure of Trypanosoma cruzi. Genetics 171 (2005) 527-543
58. Westenberger S.J., Cerqueira G.C., El-Sayed N.M., Zingales B., Campbell D.A., and Sturm N.R. Trypanosoma cruzi mitochondrial maxicircles display species- and strain-specific variation and a conserved element in the non-coding region. BMC Genomics 7 (2006) 60
59. Zafra G., Mantilla J.C., Valadares H.M., Macedo A.M., and Gonzáles C.I. Evidence of Trypanosoma cruzi II infection in Colombian chagasic patients. Parasitol. Res. 103 (2008) 731-734
60. Zicker F., Netto J.C., Zicker E.M., Oliveira R.M., and Smith P.G. Trypanosoma cruzi infection and electrocardiographic findings among active manual workers: a population-based study in central Brazil. Int. J. Epidemiol. 19 (1990) 182-186
61. Zingales B., Souto R.P., Mangia R.H., Lisboa C.V., Campbell D.A., Coura J.R., Jansen A., and Fernandes O. Molecular epidemiology of American trypanosomiasis in Brazil based on dimorphisms of rRNA and mini-exon gene sequences. Int. J. Parasitol. 28 (1998) 105-112