Glycine betaine may have opposite effects on protein stability at high and low pH values

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1794, Issue 6, 2009, Pages 929-935

  Singh, Laishram R ^b   Dar, Tanveer Ali ^a   Rahman, Safikur ^a   Jamal, Shazia ^a   Ahmad, Faizan ^a  

^a JAMIA MILLIA ISLAMIA CENTRAL UNIVERSITY   (India)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

Free energy change; Glycine betaine; Osmolyte; Preferential hydration; Protein denaturation; Protein stability

Indexed keywords

ALPHA LACTALBUMIN; BETAINE; LYSOZYME; RIBONUCLEASE A; UREA;

ARTICLE; CONCENTRATION RESPONSE; ENTHALPY; IN VITRO STUDY; IN VIVO STUDY; MATHEMATICAL COMPUTING; METHYLATION; MOLECULAR STABILITY; NONHUMAN; OSMOLARITY; PH MEASUREMENT; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN DENATURATION; PROTEIN STABILITY;

BETAINE; HYDROGEN-ION CONCENTRATION; PROTEINS;

EID: 67349108021     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2009.02.005     Document Type: Article

References (45)

1. Galinski E.A., and Trüper H.G. Microbial behavior in salt-stressed ecosystems. FEMS Microbiol. FEMS Microbiol. Rev. 15 (1994) 95-108
2. Da Costa M.S., Santos H., and Galinski E.A. An overview of the role and diversity of compatible solutes in Bacteria and Archaea. Adv. Biochem. Eng. Biotechnol. 61 (1998) 117-153
3. Roberts M.F. Osmoadaptation and osmoregulation in Archae. Front. Biosci. 5 (2000) 796-812
4. Burg M., Kwon E., and Kültz D. Regulation of gene expression by hypertonicity. Annu. Rev. Physiol. 59 (1997) 437-455
5. Rhodes D., and Hanson A.D. Quaternary ammonium and tertiary sulfonium compounds in higher plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 44 (1993) 357-384
6. Hohmann S. Osmotic adaptation in yeast-control of the yeast osmolyte system. Int. Rev. Cytol. 215 (2002) 149-187
7. Le Rudulier D., Strøm A.R., Dandekar A.M., Smith L.T., and Valentine R.C. Molecular biology of osmoregulation. Science 224 (1984) 1064-1068
8. Yancey P.H. Compatible and counteracting solutes. In: Strange K. (Ed). Cellular and Molecular Physiology of Cell Volume Regulation (1994), CRC Press, Inc., Boca Raton, FL 81-109
9. Record M.T., Courtenay E.S., Cayley D.S., and Guttman H.J. Response of E. coli to osmotic stress: large changes in amounts of cytoplasmic solutes and water. Trends Biochem. Sci. 23 (1998) 143-148
10. Courtenay E.S., Capp M.W., Anderson C.F., and Record M.T. Vapor pressure osmometry studies of osmolyte-protein interactions: implications for the action of osmoprotectants in vivo and for the interpretation of "osmotic stress" experiments in vitro. Biochemistry 39 (2000) 4455-4471
11. Timasheff S.N. Control of protein stability and reactions by weakly interacting cosolvents: the simplicity of the complicated. Adv. Prot. Chem. 51 (1998) 355-432
12. Arakawa T., and Timasheff S.N. Preferential interactions of proteins with solvent components in aqueous amino acid solutions. Arch. Biochem. Biophys. 224 (1983) 169-177
13. Santoro M.M., Liu Y., Khan S.M.A., Hou L.X., and Bolen D.W. Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry 31 (1992) 5278-5283
14. Yancey P.H., and Somero G.N. Counteraction of urea destabilization of protein structure by methylamine osmoregulatory compounds of elasmobranch fishes. Biochem. J. 183 (1979) 317-322
15. Anjum F., Rishi V., and Ahmad F. Compatibility of osmolytes with Gibbs energy of stabilization of proteins. Biochim. Biophys. Acta 1476 (2000) 75-84
16. Burg M.B., and Peters E.M. Urea and methylamines have similar effects on aldose reductase activity. Am. J. Physiol. Renal. Physiol. 273 (1998) F1048-F1053
17. Coelho-Sampaio T., Ferreira S.T., Castro Jr. E.J., and Vieyra A. Betaine counteracts urea-induced conformational changes and uncoupling of the human erythrocyte Ca2+ pump. Eur. J. Biochem. 221 (1994) 1103-1110
18. Caldas T., Demont-Caulet N., Ghazi A., and Richarme G. Thermoprotection by glycine betaine and choline. Microbiology 145 (1999) 2543-2548
19. Bourot S., Sire O., Trautwetter A., Touze T., Wu L.F., Blanco C., and Bernard T. Glycine betaine-assisted protein folding in a lysA mutant of Escherichia coli. J. Biol. Chem. 275 (2000) 1050-1056
20. Pollard A., and Wyn Jones R.G. Enzyme activities in concentrated solutions of glycinebetaine and other solutes. Planta 144 (1979) 291-298
21. Kaushik J.K., and Bhat R. Why is trehalose an exceptional protein stabilizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehalose. J. Biol. Chem. 278 (2003) 26458-26465
22. Haque I., Singh R., Ahmad F., and Moosavi-Movahedi A.K. Testing polyols' compatibility with Gibbs energy of stabilization of proteins under conditions in which they behave as compatible osmolytes. FEBS Lett. 579 (2005) 3891-3898
23. D, the Gibbs energy of stabilisation of proteins at different pH values. Biophys. Chem. 117 (2005) 1-12
24. Haque I., Islam A., Singh R., Moosavi-Movahedi A.K., and Ahmad F. Stability of proteins in the presence of polyols estimated from their guanidinium chloride-induced transition curves at different pH values and 25 °C. Biophys. Chem. 119 (2006) 224-233
25. Singh R., Haque I., and Ahmad F. Counteracting osmolyte trimethylamine N-oxide destabilizes proteins at pH below its pKa. Measurements of thermodynamic parameters of proteins in the presence and absence of trimethylamine N-oxide. J. Biol Chem. 280 (2005) 11035-11042
26. Bigelow C.C. Difference spectra of amino acids and proteins in aqueous media of high refractive index. C. R. Trav. Lab. Carlsberg 31 (1960) 305-324
27. Hamaguchi K., and Kurono A. Structure of muramidase (lysozyme). I. The effect of guanidine hydrochloride on muramidase. J. Biochem. 54 (1968) 111-122
28. Sugai S., Yashiko H., and Nita K. Equilibrium and kinetics of the unfolding of α-lactalbumin by guanidine hydrochloride. Biochim. Biophys. Acta 328 (1973) 35-41
29. Pace C.N. Determination and analysis of urea and guanidine hydrochloride denaturation curves. Methods Enzymol. 131 (1986) 266-280
30. Sinha A., Yadav S., Ahmad R., and Ahmad F. Possible origin of differences between calorimetric and equilibrium estimates of stability parameters of proteins. Biochem. J. 345 (2000) 711-717
31. Becktel W.J., and Schellman J.A. Protein stability curves. Biopolymers 26 (1987) 1859-1877
32. Taneja S., and Ahmad F. Increased thermal stability of proteins in the presence of amino acid. Biochem. J. 303 (1994) 147-153
33. Privalov P.L. Stability of proteins: small globular proteins. Adv. Protein Chem. 33 (1979) 167-241
34. Pfeil W., and Sadowski M.L. A scanning calorimetric study of bovine and human apo-lactalbumin. Studia Biophys. 109 (1985) 163-170
35. Timasheff S.N. Protein hydration, thermodynamic binding, and preferential hydration. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 9721-9726
36. Bolen D.W., and Baskakov I.V. The osmophobic effect: natural selection of a thermodynamic force in protein folding. J. Mol. Biol. 310 (2001) 955-963
37. Singh R., Dar T.A., Ahmad S., Moosavi-Movahedi A.K., and Ahmad F. A new method for determining the constant-pressure heat capacity change associated with the protein denaturation induced by guanidinium chloride (or urea). Biophys. Chem. 133 (2008) 81-89
38. Aune K.C., Salahuddin A., Zarlengo M.H., and Tanford C. Evidence for residual structure in acid- and heatdenatured proteins. J. Biol. Chem. 242 (1967) 4486-4489
39. Robertson A.D., and Baldwin R.L. Hydrogen exchange in thermally denatured ribonuclease A. Biochemistry 30 (1991) 9907-9914
40. Sosnick T.R., and Trewhella J. Denatured states of ribonuclease A have compact dimensions and residual secondary structure. Biochemistry 31 (1992) 8329-8355
41. Seshadri S., Oberg K.A., and Fink A.L. Thermally denatured ribonuclease A retains secondary structure as shown by FTIR. Biochemistry 33 (1994) 1351-1355
42. Tamura Y., and Gekko K. Compactness of thermally and chemically denatured ribonuclease A as revealed by volume and compressibility. Biochemistry 34 (1995) 1878-1884
43. Granata V., Palladino P., Tizzano B., Negro A., Berisio R., and Zagari A. A. The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH. Biopolymers 82 (2006) 234-240
44. Schiefner A., Breed J., Bosser L., Kneip S., Gade J., Holtmann G., Diederichs K., Walte W., and Bremer E. Cation-π interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coli. J. Biol. Chem. 279 (2004) 5588-5596
45. Barra L., Fontenelle C., Ermel G., Trautwetter A., Walker G.C., and Blanco C. Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34. J. Bact. 188 (2006) 7195-7204