The effect of the osmolyte trimethylamine N-oxide on the stability of the prion protein at low pH

Biopolymers

Volumn 82, Issue 3, 2006, Pages 234-240

  Granata, Vincenzo ^a   Palladino, Pasquale ^a   Tizzano, Barbara ^a   Negro, Alessandro ^b   Berisio, Rita ^c   Zagari, Adriana ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c CNR   (Italy)

Author keywords

Denaturant; Osmolyte; Prion protein; Protein stability; Trimethylamine N oxide

Indexed keywords

BIOPOLYMERS; ELECTROSTATICS; NITROGEN OXIDES; PH EFFECTS; POSITIVE IONS; THERMAL EFFECTS;

DENATURANTS; OSMOLYTES; PRION PROTEINS; PROTEIN STABILITY; TRIMETHYLAMINE N-OXIDE;

PROTEINS;

OXIDE; PRION PROTEIN; RECOMBINANT PROTEIN; TRIMETHYLAMINE OXIDE;

ARTICLE; ELECTRICITY; PH MEASUREMENT; PKA; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; ROOM TEMPERATURE; THERMAL EXPOSURE; THERMOSTABILITY;

ANIMALS; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; METHYLAMINES; MODELS, CHEMICAL; PRIONS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, SECONDARY; PRPC PROTEINS; PRPSC PROTEINS; RECOMBINANT PROTEINS; SHEEP; THERMODYNAMICS;

OVIS;

EID: 33744484080     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20481     Document Type: Article

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