Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3130-3137

  Tandon, Vishnu K ^a   Maurya, Hardesh K ^a   Mishra, Nripendra N ^b   Shukla, Praveen K ^b  

^a UNIVERSITY OF LUCKNOW   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2,3 Dichloro 1,4 naphthoquinone; Antibacterial; Antifungal; Fluconazole; Pictet Spengler cyclization

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 12 PHENYL 12,13 DIHYDROBENZO[F]NAPHTHO[2,3 B][1,4]THIAZEPINE 6,11 DIONE; 2 (3 METHOXYPHENYLTHIO) 3 (PHENYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (4 HYDROXYPHENYLAMINO) 3 (NAPHTHALEN 1 YLTHIO)NAPHTHALENE 1,4 DIONE; 2 (4 HYDROXYPHENYLAMINO) 3 (PHENYLTHIO)NAPHTHALENE 1,4 DIONE; 2 (DIPHENYLAMINO) 3 (3 METHOXYPHENYLTHIO)NAPHTHALENE 1,4 DIONE; 2 (DIPHENYLAMINO) 3 (NAPHTHALEN 1 YLTHIO)NAPHTHALENE 1,4 DIONE; 2 (DIPHENYLAMINO) 3 (PHENYLTHIO)NAPHTHALENE 1,4 DIONE; 2 (NAPHTHALEN 1 YLTHIO) 3 (PHENYLAMINO)NAPHTHALENE 1,4 DIONE; 2 [2 (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YLAMINO)ETHYL]ISOINDOLINE 1,3 DIONE; 2 [2 (3 CHLORO 1,3 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YLAMINO)ETHYL]ISOINDOLINE 1,3 DIONE; 2 AMINO 3 (3 METHOXYPHENYLSULFANYL)[1,4]NAPHTHOQUINONE; 2 AMINO 3 (NAPHTHALEN 1 YLSULFANYL)[1,4]NAPHTHOQUINONE; 2 AMINO 3 PHENYLSULFANYL[1,4]NAPHTHOQUINONE; 2 CHLORO 3 (4 HYDROXYPHENYLAMINO)NAPHTHALENE 1,4 DIONE; 2 CHLORO 3 (DIPHENYLAMINO)NAPHTHALENE 1,4 DIONE; 2 CHLORO 3 (PHENYLAMINO)NAPHTHALENE 1,4 DIONE; 2 PHENYLAMINO 3 (PHENYLTHIO)NAPHTHALENE 1,4 DIONE; 2,3 BROMO 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YLAMINOBENZONITRILE; 2,3 CHLORO 1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YLAMINOBENZONITRILE; 3 METHOXY 12 PHENYL 12,13 DIHYDROBENZO[F]NAPHTHO[2,3 B][1,4]THIAZEPINE 6,11 DIONE; AMIKACIN; AMPHOTERICIN B; FLUCONAZOLE; GENTAMICIN; KANAMYCIN; MICONAZOLE; NYSTATIN; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CRYPTOCOCCUS NEOFORMANS; CYCLIZATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PICTET SPENGLER CYCLIZATION; SPOROTHRIX SCHENCKII; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; TRICHOPHYTON;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; BACTERIA; DRUG DESIGN; FUNGI; MICROBIAL SENSITIVITY TESTS; NAPHTHOQUINONES; NITROGEN; SULFUR;

EID: 67349102757     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.006     Document Type: Article

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