Design, synthesis, and biological evaluation of 1,2,3-trisubstituted-1,4-dihydrobenzo[g]quinoxaline-5,10-diones and related compounds as antifungal and antibacterial agents

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 17, 2006, Pages 6120-6126

  Tandon, Vishnu K ^a   Yadav, Dharmendra B ^a   Maurya, Hardesh K ^a   Chaturvedi, Ashok K ^b   Shukla, Praveen K ^b  

^a UNIVERSITY OF LUCKNOW   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

1,4 Naphthoquinone derivatives; Antibacterial; Antifungal; Heterocyclic quinones; Quinoxaline 5,10 diones

Indexed keywords

1 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 2 HYDROXY 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 1 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 2 HYDROXY 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 1 BUTYL 2 HYDROXY 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 1 BUTYL 2 HYDROXY 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 1 TERT BUTYL 2 HYDROXY 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 (2 HYDROXYETHYL) 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 (2 HYDROXYETHYL) 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 (2 METHOXYPHENYL) 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 (2 METHOXYPHENYL) 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 (4 HYDROXYPHENYL) 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 (4 HYDROXYPHENYL) 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 ISOBUTYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 ISOBUTYL 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 ISOPROPYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 ISOPROPYL 3 METHYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 1 PHENYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 2 HYDROXY 3 METHYL 1 PHENYL 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; 4 TERT BUTYL 3 HYDROXY 1,4 DIHYDROBENZO[G]QUINOXALINE 5,10 DIONE; AMPHOTERICIN B; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; FLUCONAZOLE; GENTAMICIN; MICONAZOLE; N 3 (CHLORO 1,4 NAPHTHOQUINON 2 YL)ALANINE ETHYL ESTER; N 3 (CHLORO 1,4 NAPHTHOQUINON 2 YL)GLYCINE ETHYL ESTER; NYSTATIN; QUINOXALINE DERIVATIVE; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SUBSTITUTION; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SPOROTHRIX SCHENCKII; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; DRUG DESIGN; FUNGI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUINOXALINES;

CANDIDA ALBICANS; ESCHERICHIA COLI; FILOBASIDIELLA NEOFORMANS; KLEBSIELLA PNEUMONIAE; SPOROTHRIX SCHENCKII;

EID: 33746081249     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.029     Document Type: Article

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