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Volumn 59, Issue 1, 2009, Pages 17-30

Improving bioreactor cultivation conditions for sensitive cell lines by dynamic membrane aeration

Author keywords

Bubble free bioreactor aeration; Cell cultivation; Fouling; Low shear; Membrane; Sticky cells

Indexed keywords

BLOOD CLOTTING FACTOR 8; SILICONE;

EID: 67349085153     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-009-9189-9     Document Type: Article
Times cited : (20)

References (37)
  • 1
    • 0026849082 scopus 로고
    • The use of independently sealed microporous hollow fiber membranes for oxygenation of water: Model development
    • T Ahmed MJ Semmens 1992 The use of independently sealed microporous hollow fiber membranes for oxygenation of water: model development J Membr Sci 69 11 20
    • (1992) J Membr Sci , vol.69 , pp. 11-20
    • Ahmed, T.1    Semmens, M.J.2
  • 2
    • 0026849081 scopus 로고
    • Use of sealed end hollow fibres for bubbleless membrane aeration: Experimental studies
    • T Ahmed MJ Semmens 1992 Use of sealed end hollow fibres for bubbleless membrane aeration: experimental studies J Membr Sci 69 1 10
    • (1992) J Membr Sci , vol.69 , pp. 1-10
    • Ahmed, T.1    Semmens, M.J.2
  • 3
    • 0030072014 scopus 로고    scopus 로고
    • Use of transverse flow hollow fibers for bubbleless membrane aeration
    • DOI 10.1016/0043-1354(95)00167-0
    • T Ahmed MJ Semmens 1996 Use of transverse flow hollow fibers for bubbleless membrane aeration Water Res 30 440 446 (Pubitemid 26007277)
    • (1996) Water Research , vol.30 , Issue.2 , pp. 440-446
    • Ahmed, T.1    Semmens, M.J.2
  • 4
    • 0742284137 scopus 로고    scopus 로고
    • Oxygen transfer characteristics of hollow-fiber, composite membranes
    • DOI 10.1016/S1093-0191(03)00036-4, PII S1093019103000364
    • T Ahmed MJ Semmens MA Voss 2004 Oxygen transfer characteristics of hollow-fiber, composite membranes Adv Environ Res 8 637 646 (Pubitemid 38155270)
    • (2004) Advances in Environmental Research , vol.8 , Issue.3-4 , pp. 637-646
    • Ahmed, T.1    Semmens, M.J.2    Voss, M.A.3
  • 8
    • 0942278925 scopus 로고    scopus 로고
    • Turbulent flow technique for the estimation of oxygen diffusive permeability of membranes for the oxygenation of blood and other cell suspensions
    • DOI 10.1016/j.memsci.2003.10.040
    • C Catapano R Hornscheidt A Wodetzki U Baurmeister 2004 Turbulent flow technique for the estimation of oxygen diffusive permeability of membranes fort the oxygenation of blood and other cell suspensions J Membr Sci 230 131 139 (Pubitemid 38142523)
    • (2004) Journal of Membrane Science , vol.230 , Issue.1-2 , pp. 131-139
    • Catapano, G.1    Hornscheidt, R.2    Wodetzki, A.3    Baurmeister, U.4
  • 9
    • 0034308263 scopus 로고    scopus 로고
    • Animal-cell damage in sparged bioreactors
    • Y Chisti 2000 Animal-cell damage in sparged bioreactors TIBTECH 18 420 432
    • (2000) TIBTECH , vol.18 , pp. 420-432
    • Chisti, Y.1
  • 10
    • 0035313635 scopus 로고    scopus 로고
    • Industrial choices for protein production by large-scale cell culture
    • DOI 10.1016/S0958-1669(00)00197-X
    • L Chu DK Robinson 2001 Industrial choices for protein production by large-scale cell culture Curr Opin Biotechnol 12 180 187 (Pubitemid 32247406)
    • (2001) Current Opinion in Biotechnology , vol.12 , Issue.2 , pp. 180-187
    • Chu, L.1    Robinson, D.K.2
  • 12
    • 0024761876 scopus 로고
    • Bubble-free aeration using membranes: Mass transfer analysis
    • DOI 10.1016/S0376-7388(00)80862-5
    • P Côté JL Bersillon A Huyard 1989 Bubble-free aeration using membranes: mass transfer analysis J Membr Sci 47 91 108 (Pubitemid 20053137)
    • (1989) Journal of Membrane Science , vol.47 , Issue.1-2 , pp. 91-106
    • Cote, P.1    Bersillon, J.-L.2    Huyard, A.3
  • 13
    • 0024125127 scopus 로고
    • Bioreactor engineering: The design and optimization of reactors with living cells
    • JM Engasser 1988 Bioreactor engineering: the design and optimization of reactors with living cells Chem Eng Sci 43 1739 1748
    • (1988) Chem Eng Sci , vol.43 , pp. 1739-1748
    • Engasser, J.M.1
  • 14
    • 33749236399 scopus 로고    scopus 로고
    • Established bioprocesses for producing antibodies as a basis for future planning
    • DOI 10.1007/10-014, Cell Culture Engineering
    • SS Farid 2006 Cell established bioprocesses for producing antibodies as a basis for future planning Adv Biochem Engin/Biotechnol 101 1 42 (Pubitemid 44617164)
    • (2006) Advances in Biochemical Engineering/Biotechnology , vol.101 , pp. 1-42
    • Farid, S.S.1
  • 16
    • 34547984700 scopus 로고    scopus 로고
    • Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien
    • B Frahm S Kirchner J Kauling H Brod U Langer B Bödeker 2007 Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien Chem Ing Tech 79 1052 1058
    • (2007) Chem Ing Tech , vol.79 , pp. 1052-1058
    • Frahm, B.1    Kirchner, S.2    Kauling, J.3    Brod, H.4    Langer, U.5    Bödeker, B.6
  • 17
    • 0018105104 scopus 로고
    • Untersuchungen zum Homogenisieren von Flüssigkeiten und Gasen
    • HJ Henzler 1978 Untersuchungen zum Homogenisieren von Flüssigkeiten und Gasen VDI-Forschungsheft 587 7
    • (1978) VDI-Forschungsheft , vol.587 , pp. 7
    • Henzler, H.J.1
  • 19
    • 0027155318 scopus 로고
    • Oxygenation of cell cultures
    • DOI 10.1007/BF00369033
    • HJ Henzler J Kauling 1993 Oxygenation of cell cultures Bioprocess Eng 9 61 75 (Pubitemid 23156458)
    • (1993) Bioprocess Engineering , vol.9 , Issue.2-3 , pp. 61-75
    • Henzler, H.-J.1    Kauling, D.J.2
  • 20
    • 0025920850 scopus 로고
    • Effect of mixing behaviour on gas-liquid mass transfer in highly viscous, stirred non-Newtonian liquids
    • HJ Henzler G Obernosterer 1991 Effect of mixing behaviour on gas-liquid mass transfer in highly viscous, stirred non-newtonian liquids Chem Eng Technol 14 1 10 (Pubitemid 21715568)
    • (1991) Chemical Engineering and Technology , vol.14 , Issue.1 , pp. 1-10
    • Hans-Juergen, H.1    Gerd, O.2
  • 21
    • 0001845288 scopus 로고    scopus 로고
    • Bubble column reactor for mass propagation of animal cells in suspension culture
    • HWD Katinger W Schreier E Krömer 1997 Bubble column reactor for mass propagation of animal cells in suspension culture Ger Chem Eng 2 31
    • (1997) Ger Chem Eng , vol.2 , pp. 31
    • Katinger, H.W.D.1    Schreier, W.2    Krömer, E.3
  • 22
    • 53349099079 scopus 로고    scopus 로고
    • Use of moving aeration membrane bioreactor for the efficient production of tissue type plasminogen activator in serum free medium
    • HK Kim MS Ham JS Hong JH Lee KY Park HY Lee 1996 Use of moving aeration membrane bioreactor for the efficient production of tissue type plasminogen activator in serum free medium Biotechnol Bioprocess Eng 1 32 35
    • (1996) Biotechnol Bioprocess Eng , vol.1 , pp. 32-35
    • Kim, H.K.1    Ham, M.S.2    Hong, J.S.3    Lee, J.H.4    Park, K.Y.5    Lee, H.Y.6
  • 24
    • 67349197397 scopus 로고
    • European patent 0172478
    • Lehmann J (1989) European patent 0172478
    • (1989)
    • Lehmann, J.1
  • 25
    • 0023080706 scopus 로고
    • Bubble-free cell culture aeration with porous moving membranes
    • J Lehmann GW Piehl R Schulz 1987 Bubble-free cell culture aeration with porous moving membranes Develop Biol Standard 66 227 240
    • (1987) Develop Biol Standard , vol.66 , pp. 227-240
    • Lehmann, J.1    Piehl, G.W.2    Schulz, R.3
  • 26
    • 4043130854 scopus 로고    scopus 로고
    • Quantitative studies of cell-bubble interactions and cell damage at different pluronic F-68 and cell concentrations
    • DOI 10.1021/bp0342405
    • N Ma JJ Chalmers JG Aunins W Zhou L Xie 2004 Quantitative studies of cell-bubble interactions and cell damage at different pluronic F-68 and cell concentrations Biotechnol Progr 20 1183 1191 (Pubitemid 39059632)
    • (2004) Biotechnology Progress , vol.20 , Issue.4 , pp. 1183-1191
    • Ma, N.1    Chalmers, J.J.2    Aunins, J.G.3    Zhou, W.4    Xie, L.5
  • 27
    • 0342656672 scopus 로고    scopus 로고
    • A novel approach for the determination of mechanical stresses in gas-liquid reactors
    • EU Mahnke K Büscher DC Hempel 2000 A novel approach for the determination of mechanical stresses in gas-liquid reactors Chem Eng Technol 23 509 513 (Pubitemid 30442097)
    • (2000) Chemical Engineering and Technology , vol.23 , Issue.6 , pp. 509-513
    • Mahnke, E.U.1    Busclier, K.2    Hempel, D.C.3
  • 28
    • 0026473150 scopus 로고
    • Engineering approach to mixing quantification in bioreactors
    • B Mayr 1992 Engineering approach to mixing quantification in bioreactors Bioprocess Eng 8 137 143
    • (1992) Bioprocess Eng , vol.8 , pp. 137-143
    • Mayr, B.1
  • 29
    • 0025486770 scopus 로고
    • Sparged animal cell bioreactors: Mechanism of cell damage and pluronic F-68 protection
    • DW Murhammer CF Goochee 1990 Sparged animal cell bioreactors: mechanism of cell damage and pluronic F-68 protection Biotechnol Progr 6 391 397
    • (1990) Biotechnol Progr , vol.6 , pp. 391-397
    • Murhammer, D.W.1    Goochee, C.F.2
  • 30
    • 10044248385 scopus 로고    scopus 로고
    • Experimental study of a ceramic microsparging aeration system in a pilot-scale
    • D Nehring P Czermak J Vorlop H Lübben 2004 Experimental study of a ceramic microsparging aeration system in a pilot-scale Biotechnol Progr 20 1710 1717
    • (2004) Biotechnol Progr , vol.20 , pp. 1710-1717
    • Nehring, D.1    Czermak, P.2    Vorlop, J.3    Lübben, H.4
  • 31
    • 0002912166 scopus 로고    scopus 로고
    • Fermentation mixing scale up techniques
    • Y Oldshue 1996 Fermentation mixing scale up techniques Biotechnol Bioeng 8 3 24
    • (1996) Biotechnol Bioeng , vol.8 , pp. 3-24
    • Oldshue, Y.1
  • 35
    • 0026473370 scopus 로고
    • Optimal design of the tubular microporous membrane aerator for shear sensitive cell cultures
    • WW Su HS Caram AE Humphrey 1992 Optimal design of the tubular microporous membrane aerator for shear sensitive cell cultures Biotechnol Progr 8 19 24
    • (1992) Biotechnol Progr , vol.8 , pp. 19-24
    • Su, W.W.1    Caram, H.S.2    Humphrey, A.E.3
  • 36
    • 0028533059 scopus 로고
    • Bubble bed reactor: A reactor design to minimize the damage of bubble aeration on animal cells
    • HG Sucker M Jordan HM Eppenberger F Widmer 1994 Bubble bed reactor: a reactor design to minimize the damage of bubble aeration on animal cells Biotechnol Bioeng 44 1246 1254
    • (1994) Biotechnol Bioeng , vol.44 , pp. 1246-1254
    • Sucker, H.G.1    Jordan, M.2    Eppenberger, H.M.3    Widmer, F.4
  • 37
    • 0024034111 scopus 로고
    • SCALE-UP of BIOREACTORS for FERMENTATION of MAMMALIAN CELL CULTURES, with SPECIAL REFERENCE to OXYGEN SUPPLY and MICROCARRIER MIXING.
    • J Vorlop J Lehmann 1988 Scale-up of bioreactors for fermentation of mammalian cell cultures, with special reference to oxygen supply and microcarrier mixing Chem Eng Technol 11 171 178 (Pubitemid 18634410)
    • (1988) Chemical Engineering and Technology , vol.11 , Issue.3 , pp. 171-178
    • Juergen, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.