Cetrorelix protocol versus gonadotropin-releasing hormone analog suppression long protocol for superovulation in intracytoplasmic sperm injection patients older than 40

Fertility and Sterility

Volumn 91, Issue 5, 2009, Pages 1842-1847

  Sbracia, Marco ^a   Colabianchi, Julio ^b   Giallonardo, Annalise ^b   Giannini, Pierluigi ^b   Piscitelli, Claudio ^b   Morgia, Francesco ^b   Montigiani, Monica ^b   Schimberni, Mauro ^b  

^a Center of Endocrinology and Reproductive Medicine   (Italy)

^b Bioroma   (Italy)

Author keywords

cetrorelix; controlled ovarian hyperstimulation; GnRH analog; GnRH antagonist; IVF outcome; long protocol

Indexed keywords

BUSERELIN; CETRORELIX; GONADORELIN ANTAGONIST; GONADORELIN DERIVATIVE; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESTROGEN BLOOD LEVEL; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; OOCYTE RETRIEVAL; OVARY HYPERSTIMULATION; PREGNANCY RATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUPEROVULATION;

ADULT; AGE FACTORS; FEMALE; FERTILIZATION IN VITRO; GONADOTROPIN-RELEASING HORMONE; HUMANS; INHIBINS; MALE; MIDDLE AGED; PREGNANCY; PREGNANCY RATE; SPERM INJECTIONS, INTRACYTOPLASMIC; SUPEROVULATION;

EID: 67349084053     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.02.165     Document Type: Article

References (43)

1. Porter R.N., Smith W., Craft I.L., Abdulwanhid N.A., and Jacobs H.S. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins. Lancet 2 (1984) 1284-1285
2. Smitz J., Devroey P., Braeckmans P., Camus M., Van Waesberghe L., Wisanto A., et al. Management of failed cycles in an IVF/GIFT programme with the combination of a GnRH analogue and HMG. Hum Reprod 4 (1987) 309-314
3. Hughes E.G., Fedorkow D.M., Daya S., Sagle M.A., Van de Koppel P., and Collins J.A. The routine use of gonadotropin-releasing hormone agonists prior to in vitro fertilization and gamete intrafallopian transfer: a meta-analysis of randomized controlled trials. Fertil Steril 5 (1992) 888-896
4. Harrison R., Kondaveeti U., Barry-Kinsella C., Gordon A., Drudy L., Cottell E., et al. Should gonadotropin-releasing hormone down-regulation therapy be routine in vitro fertilization?. Fertil Steril 62 (1994) 568-573
5. Neveu S., Hedon B., Bringer J., Chinchole J.M., Arnal F., Humeau C., et al. Ovarian stimulation by a combination of a gonadotropin-releasing hormone agonist and gonadotropins for in vitro fertilization. Fertil Steril 47 (1987) 639-643
6. Rutherford A.J., Subak-Sharpe R.J., Dawson K.J., Margara R.A., Franks S., and Winston R.M. Improvement of in vitro fertilisation after treatment with buserelin, an agonist of luteinizing hormone releasing hormone. Br Med J 25 (1988) 1765-1768
7. Janssens R.M., Lambalk C.B., Vermeiden J.P., Schats R., Bernards J.M., Rekers-Mombarg L.T., et al. Dose-finding study of triptorelin acetate for the prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study. Hum Reprod 15 (2000) 2333-2340
8. Diedrich K., Diedrich C., Santos E., Zoll C., al-Hasani S., Reissmann T., et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod 9 (1994) 788-791
9. Olivennes F., Fanchin R., Bouchard P., de Ziegler D., Taieb J., Selva J., et al. The single or dual administration of the gonadotropin-releasing hormone antagonist Cetrorelix in an in vitro fertilization-embryo transfer program. Fertil Steril 62 (1994) 468-476
10. Olivennes F., Fanchin R., Bouchard P., Taieb J., Selva J., and Frydman R. Scheduled administration of a gonadotrophin-releasing hormone antagonist (Cetrorelix) on day 8 of in-vitro fertilization cycles: a pilot study. Hum Reprod 10 (1995) 1382-1386
11. Reissmann T., Felberbaum R., Diedrich K., Engel J., Comaru-Schally A.M., and Schally A.V. Development and applications of luteinizing hormone-releasing hormone antagonists in the treatment of infertility: an overview. Hum Reprod 10 (1995) 1974-1981
12. Felberbaum R., Reissmann T., Kupker W., Al-Hasani S., Bauer O., Schill T., et al. Hormone profiles under ovarian stimulation with human menopausal gonadotropin (hMG) and concomitant administration of the gonadotropin releasing hormone (GnRH)-antagonist Cetrorelix at different dosages. J Assist Reprod Genet 13 (1996) 216-222
13. Albano C., Smitz J., Camus M., Riethmuller-Winzen H., Van Steirteghem A., and Devroey P. Comparison of different doses of gonadotropin-releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation. Fertil Steril 67 (1997) 917-922
14. Olivennes F., Alvarez S., Bouchard P., Fanchin R., Salat-Baroux J., and Frydman R. The use of a GnRH antagonist (Cetrorelix) in a single dose protocol in IVF-embryo transfer: a dose finding study of 3 versus 2 mg. Hum Reprod 13 (1998) 2411-2414
15. Albano C., Smitz J., Tournaye H., Riethmuller-Winzen H., Van Steirteghem A., and Devroey P. Luteal phase and clinical outcome after human menopausal gonadotrophin/gonadotrophin releasing hormone antagonist treatment for ovarian stimulation in in-vitro fertilization/intracytoplasmic sperm injection cycles. Hum Reprod 14 (1999) 1426-1430
16. Olivennes F., Belaisch-Allart J., Emperaire J.C., Dechaud H., Alvarez S., Moreau L., et al. Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin). Fertil Steril 73 (2000) 314-320
17. Albano C., Felberbaum R.E., Smitz J., Riethmuller-Winzen H., Engel J., Diedrich K., et al. Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin. European Cetrorelix Study Group. Hum Reprod 15 (2000) 526-531
18. Felberbaum R.E., Albano C., Ludwig M., Riethmuller-Winzen H., Grigat M., Devroey P., et al. Ovarian stimulation for assisted reproduction with HMG and concomitant midcycle administration of the GnRH antagonist cetrorelix according to the multiple dose protocol: a prospective uncontrolled phase III study. Hum Reprod 15 (2000) 1015-1020
19. Ludwig M., Katalinic A., Banz C., Schroder A.K., Loning M., Weiss J.M., et al. Tailoring the GnRH antagonist cetrorelix acetate to individual patients' needs in ovarian stimulation for IVF: results of a prospective, randomized study. Hum Reprod 17 (2002) 2842-2845
20. Loutradis D., Stefanidis K., Drakakis P., Milingos S., Antsaklis A., and Michalas S. A modified gonadotropin-releasing hormone (GnRH) antagonist protocol failed to increase clinical pregnancy rates in comparison with the long GnRH protocol. Fertil Steril 82 (2004) 1446-1448
21. Wilcox J., Potter D., Moore M., Ferrande L., Kelly E., and Cap IV Investigator Group. Prospective, randomized trial comparing cetrorelix acetate and ganirelix acetate in a programmed, flexible protocol for premature luteinizing hormone surge prevention in assisted reproductive technologies. Fertil Steril 84 (2005) 108-117
22. Craft I., Gorgy A., Hill J., Menon D., and Podsiadly B. Will GnRH antagonists provide new hope for patients considered "difficult responders" to GnRH agonist protocols?. Hum Reprod 14 (1999) 2959-2962
23. Akman M.A., Erden H.F., Tosun S.B., Bayazit N., Aksoy E., and Bahceci M. Addition of GnRH antagonist in cycles of poor responders undergoing IVF. Hum Reprod 15 (2000) 2145-2147
24. Akman M.A., Erden H.F., Tosun S.B., Bayazit N., Aksoy E., and Bahceci M. Comparison of agonistic flare-up-protocol and antagonistic multiple dose protocol in ovarian stimulation of poor responders: results of a prospective randomized trial. Hum Reprod 16 (2001) 868-870
25. Cheung L.P., Lam P.M., Lok I.H., Chiu T.T., Yeung S.Y., Tjer C.C., et al. GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial. Hum Reprod 20 (2005) 616-621
26. Mohamed K.A., Davies W.A., Allsopp J., and Lashen H. Agonist "flare-up" versus antagonist in the management of poor responders undergoing in vitro fertilization treatment. Fertil Steril 83 (2005) 331-335
27. Shapiro D.B., Mitchell-Leef D., Carter M., and Nagy Z.P. Ganirelix acetate use in normal- and poor-prognosis patients and the impact of estradiol patterns. Fertil Steril 83 (2005) 666-670
28. Schmidt D.W., Bremner T., Orris J.J., Maier D.B., Benadiva C.A., and Nulsen J.C. A randomized prospective study of microdose leuprolide versus ganirelix in in vitro fertilization cycles for poor responders. Fertil Steril 83 (2005) 1568-1571
29. Chung K., Krey L., Katz J., and Noyes N. Evaluating the role of exogenous luteinizing hormone in poor responders undergoing in vitro fertilization with gonadotropin-releasing hormone antagonists. Fertil Steril 84 (2005) 313-318
30. Malmusi S., La Marca A., Giulini S., Xella S., Tagliasacchi D., Marsella T., et al. Comparison of a gonadotropin-releasing hormone (GnRH) antagonist and GnRH agonist flare-up regimen in poor responders undergoing ovarian stimulation. Fertil Steril 84 (2005) 402-406
31. Sbracia M., Farina A., Poverini R., Morgia F., Schimberni M., and Aragona C. Short versus long gonadotropin-releasing hormone analogue suppression protocols for superovulation in patients ≥40 years old undergoing intracytoplasmic sperm injection. Fertil Steril 84 (2005) 644-648
32. Palermo G., Joris H., Devroey P., and Van Sterteghen A.L. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 340 17 (1992) 8
33. Veeck L.L. An atlas of human gametes and conceptus (1999), Parthenon Publishing, London, UK
34. Al-Inany H.G., Abou-Setta A.M., and Aboulghar M. Gonadotrophin-releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev 3 (2006) CD001750
35. Griesinger G., Diedrich K., Tarlatzis B.C., and Kolibianakis E.M. GnRH-antagonists in ovarian stimulation for IVF in patients with poor response to gonadotrophins, polycystic ovary syndrome, and risk of ovarian hyperstimulation: a meta-analysis. Reprod Biomed Online 13 (2006) 628-638
36. Acevedo B., Sanchez M., Gomez J.L., Cuadros J., Ricciarelli E., and Hernandez E.R. Luteinizing hormone supplementation increases pregnancy rates in gonadotropin-releasing hormone antagonist donor cycles. Fertil Steril 82 (2004) 343-347
37. Griesinger G., Schultze-Mosgau A., Dafopoulos K., Schroeder A., Schroer A., von Otte S., et al. Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol. Hum Reprod 20 (2005) 1200-1206
38. Cedrin-Durnerin I., Grange-Dujardin D., Laffy A., Parneix I., Massin N., Galey Theron L., et al. Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study. Hum Reprod 19 (2004) 1979-1984
39. Klein N.A., Harper A.J., Houmard B.S., Sluss P.M., and Soules M.R. Is the short follicular phase in older women secondary to advanced or accelerated dominant follicle development?. J Clin Endocrinol Metab 87 (2002) 5746-5750
40. van Zonneveld P., Scheffer G.J., Broekmans F.J., Blankenstein M.A., de Jong F.H., Looman C.W., et al. Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women. Hum Reprod 18 (2003) 495-501
41. Klein N.A., Battaglia D.E., Fujimoto V.Y., Davis G.S., Bremner W.J., and Soules M.R. Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women. J Clin Endocrinol Metab 81 (1996) 1038-1045
42. Klein N.A., Illingworth P.J., Groome N.P., McNeilly A.S., Battaglia D.E., and Soules M.R. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab 81 (1996) 2742-2745
43. Mahutte N.G., and Arici A. Role of gonadotropin-releasing hormone antagonists in poor responders. Fertil Steril 87 (2007) 241-249