Tailoring the GnRH antagonist cetrorelix acetate to individual patient's needs in ovarian stimulation for IVF: Results of a prospective, randomized study

Human Reproduction

Volumn 17, Issue 11, 2002, Pages 2842-2845

  Ludwig, M ^a   Katalinic, A ^b   Banz, C ^a   Schroder A K ^a   Loning M ^a   Weiss, J M ^a   Diedrich, K ^a  

^a University Clinic   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Cetrorelix; Follitropin ; GnRH antagonist; Ovarian stimulation; Recombinant FSH

Indexed keywords

CETRORELIX; CHORIONIC GONADOTROPIN; ESTRADIOL; GONADORELIN ANTAGONIST; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; DRUG DERIVATIVE; FOLLITROPIN; GONADORELIN; HORMONE; HORMONE ANTAGONIST; RECOMBINANT PROTEIN;

ADULT; ARTICLE; CELL COUNT; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EMBRYO TRANSFER; ESTRADIOL BLOOD LEVEL; FERTILIZATION IN VITRO; HUMAN; INFERTILITY; MAJOR CLINICAL STUDY; OOCYTE; OVARY FOLLICLE; OVULATION INDUCTION; PATIENT MONITORING; PREGNANCY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL PARAMETERS; TREATMENT OUTCOME; BLOOD; CYTOLOGY; DRUG ADMINISTRATION; DRUG ANTAGONISM; ECHOGRAPHY; FEMALE; METHODOLOGY; TRANSPLANTATION;

ADULT; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ESTRADIOL; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HORMONES; HUMANS; OOCYTES; OVARIAN FOLLICLE; OVULATION INDUCTION; RECOMBINANT PROTEINS; TISSUE AND ORGAN HARVESTING; TREATMENT OUTCOME;

EID: 0036852911     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/17.11.2842     Document Type: Article

References (9)

1. Al-Inany, H. and Aboulghar, M. (2002) GnRH antagonists in assisted conception: a Cochrane Review. Hum. Reprod., 17, 874-885.
2. Ludwig, M., Felberbaum, R.E., Devroey, P., Albano, C., Riethmüller-Winzen, H., Schüler, A., Engel, J. and Diedrich, K. (2000a) Significant reduction of the incidence of ovarian hyperstimulation syndrome (OHSS) by using the LHRH antagonist Cetrorelix in controlled ovarian stimulation for assisted reproduction. Arch. Gynecol. Obstet., 264, 29-32.
3. Ludwig, M., Felberbaum, R.E., Hamm, W., Riethmüller-Winzen, H. and Diedrich, K. (2000b) Cetrorelix (Cetrotide®) im Mehrfachgrabe - Protokoll zur ovariellen Stimulation bei der IVF. Reproduktionsmedizin, 16, 390-399.
4. Ludwig, M., Schöpper, B., Katalinic, A., Sturm, R., l-Hasani, S. and Diedrich, K. (2000c) Experience with the elective transfer of two embryos under the conditions of the German Embryo Protection Law: results of a retrospective data analysis of 2573 transfer cycles. Hum. Reprod. 15, 319-324.
5. Ludwig, M., Katalinic, A. and Diedrich, K. (2001) Use of GnRH antagonists in ovarian stimulation for ART compared with the long protocol: a meta-analysis. Arch. Gynecol. Obstet., 265, 175-182.
6. Olivennes, F., Belaisch-Allart, J., Emperaire, J.C., Dechaud, H., Alvarez, S., Moreau, L., Nicollet, B., Zorn, J.R., Bouchard, P. and Frydman, R. (2000) A prospective randomized controlled study in IVF-ET with a single dose of a LH-RH antagonist (Cetrorelix) or a depot formula of a LH-RH agonist (Triptoterelin). Fertil. Steril., 73, 314-320.
7. Pantos, C., Thornton, S.J., Speirs, A.L. and Johnston, I. (1990) Increasing the human menopausal gonadotropin dose - does the response really improve? Fertil. Steril., 53, 436-439.
8. van Hooff, M.H., Alberda, A.T., Huisman, G.J., Zeilmaker, G.H. and Leeretvend, R.A. (1993) Doubling the human menopausal gonadotrophin dose in the course of an in-vitro fertilization treatment cycle in low responders: a randomized study. Hum. Reprod., 8, 369-373.
9. Wikland, M., Bergh, C., Borg, K., Hillensjo, T., Howles, C.M., Knutsson, A., Nilsson, L. and Wood, M. (2001) A prospective, randomized comparison of two starting doses of recombinant FSH in combination with cetrorelix in women undergoing ovarian stimulation for IVF/ICSI. Hum. Reprod., 16, 1676-1681.