No static at all: A new perspective on molecular architecture of the tight junction

Annals of the New York Academy of Sciences

Volumn 1165, Issue , 2009, Pages 314-322

  Graham, W Vallen ^a   Marchiando, Amanda M ^a   Shen, Le ^a   Turner, Jerrold R ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

FRAP; Myosin; Occludin; TNF

Indexed keywords

MYOSIN LIGHT CHAIN 2; MYOSIN LIGHT CHAIN KINASE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; CYTOKINE; MEMBRANE PROTEIN;

ARTICLE; CROHN DISEASE; CYTOKINE RELEASE; DIARRHEA; INTESTINE EPITHELIUM; T LYMPHOCYTE ACTIVATION; TIGHT JUNCTION; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE PERMEABILITY; HUMAN; INTESTINE MUCOSA; LYMPHOCYTE ACTIVATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE PERMEABILITY; CYTOKINES; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MYOSIN-LIGHT-CHAIN KINASE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 67249119063     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04050.x     Document Type: Article

References (60)

1. Furuse, M., M. Hata, K. Furuse, et al. 2002. Claudinbased tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156: 1099-1111.
2. Simon, D.B., Y. Lu, K.A. Choate, et al. 1999. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science 285: 103- 106.
3. Fordtran, J.S. 1975. Stimulation of active and passive sodium absorption by sugars in the human jejunum. J. Clin. Invest. 55: 728-737.
4. Diamond, J.M. & E.M. Wright. 1969. Biological membranes: the physical basis of ion and nonelectrolyte selectivity. Annu. Rev. Physiol. 31: 581- 646.
5. Pappenheimer, J.R. 1993. On the coupling of membrane digestion with intestinal absorption of sugars and amino acids. Am. J. Physiol. 265: G409-417.
6. Hermiston, M.L. & J.I. Gordon. 1995. In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation, and regulation of programmed cell death. J. Cell Biol. 129: 489-506.
7. Mitic, L.L. & J.M. Anderson. 1998. Molecular architecture of tight junctions. Annu. Rev. Physiol. 60: 121-142.
8. Van Itallie, C.M. & J.M. Anderson. 1997. Occludin confers adhesiveness when expressed in fibroblasts. J. Cell Sci. 110: 1113-1121.
9. Umeda, K., J. Ikenouchi, S. Katahira-Tayama, et al. 2006. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 126: 741-754.
10. Furuse, M. & S. Tsukita. 2006. Claudins in occluding junctions of humans and flies. Trends Cell Biol. 16: 181-188.
11. Tsukita, S., M. Furuse & M. Itoh. 2001. Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell Biol. 2: 285-293.
12. Pappenheimer, J.R. & K.Z. Reiss. 1987. Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J. Membr. Biol. 100: 123-136.
13. Diamond, J.M. & W.H. Bossert. 1967. Standinggradient osmotic flow. A mechanism for coupling of water and solute transport in epithelia. J. Gen. Physiol. 50: 2061-2083.
14. Turner, J.R. 2006. Molecular basis of epithelial barrier regulation: from basic mechanisms to clinical application. Am. J. Pathol. 169: 1901-1909.
15. Farquhar, M. & G. Palade. 1963. Junctional complexes in various epithelia. J. Cell Biol. 17: 375-412.
16. Staehelin, L.A., T.M. Mukherjee & A.W. Williams. 1969. Freeze-etch appearance of the tight junctions in the epithelium of small and large intestine of mice. Protoplasma 67: 165-184.
17. Tisher, C.C. & W.E. Yarger. 1973. Lanthanum permeability of the tight junction (zonula occludens) in the renal tubule of the rat. Kidney Int. 3: 238-250.
18. Bentzel, C.J., B. Hainau, A. Edelman, et al. 1976. Effect of plant cytokinins on microfilaments and tight junction permeability. Nature 264: 666-668.
19. Tice, L.W., R.L. Carter & M.B. Cahill. 1979. Changes in tight junctions of rat intestinal crypt cells associated with changes in their mitotic activity. Tissue Cell 11: 293-316.
20. Atisook, K. & J.L. Madara. 1991. An oligopeptide permeates intestinal tight junctions at glucose-elicited dilatations. Implications for oligopeptide absorption. Gastroenterol. 100: 719-724.
21. +- glucose cotransport. Adv. Drug. Deliv. Rev. 41: 265-281.
22. Madara, J.L. & J.R. Pappenheimer. 1987. Structural basis for physiological regulation of paracellular pathways in intestinal epithelia. J. Membr. Biol. 100: 149- 164.
23. Pappenheimer, J.R. 1987. Physiological regulation of transepithelial impedance in the intestinal mucosa of rats and hamsters. J. Membr. Biol. 100: 137- 148.
24. Hollander, D. 1989. Is Crohn's a tight junction disease? Gut 21: 315-319.
25. Hollander, D., C.M. Vadheim, E. Brettholz, et al. 1986. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann. Intern. Med. 105: 883- 885.
26. May, G.R., L.R. Sutherland & J.B. Meddings. 1993. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterol. 104: 1627-1632.
27. Clayburgh, D.R., M.W. Musch, M. Leitges, et al. 2006. Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo. J. Clin. Invest. 116: 2682- 2694.
28. Meddings, J.B. & H. Westergaard. 1989. Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants. Clin. Sci. (Lond.) 76: 403-413.
29. Sadowski, D.C. & J.B. Meddings. 1993. Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model. Can. J. Physiol. Pharmacol. 71: 835-839.
30. Wyatt, J., H. Vogelsang, W. Hubl, et al. 1993. Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341: 1437-1439.
31. Buhner, S., C. Buning, J. Genschel, et al. 2006. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut 55: 342-347.
32. Madsen, K.L., D. Malfair, D. Gray, et al. 1999. Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora. Inflamm. Bowel Dis. 5: 262-270.
33. Marini, M., G. Bamias, J. Rivera-Nieves, et al. 2003. TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proc. Natl. Acad. Sci. USA 100: 8366-8371.
34. Suenaert, P., V. Bulteel, L. Lemmens, et al. 2002. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am. J. Gastroenterol. 97: 2000-2004.
35. Zeissig, S., C. Bojarski, N. Buergel, et al. 2004. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 53: 1295- 1302.
36. Mullin, J.M., K.V. Laughlin, C.W. Marano, et al. 1992. Modulation of tumor necrosis factor-induced increase in renal (LLC-PK1) transepithelial permeability. Am. J. Physiol. 263: F915-924.
37. Zolotarevsky, Y., G. Hecht, A. Koutsouris, et al. 2002. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterol. 123: 163-172.
38. Wang, F., W.V. Graham, Y. Wang, et al. 2005. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am. J. Pathol. 166: 409-419.
39. Ma, T.Y., M.A. Boivin, D. Ye, et al. 2005. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am. J. Physiol. - Gastrointest. Liver Physiol. 288: G422-430.
40. Graham, W.V., F. Wang, D.R. Clayburgh, et al. 2006. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J. Biol. Chem. 281: 26205-26215.
41. Blair, S.A., S.V. Kane, D.R. Clayburgh, et al. 2006. Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease. Lab. Invest. 86: 191-201.
42. Musch, M.W., L.L. Clarke, D. Mamah, et al. 2002. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J. Clin. Invest. 110: 1739-1747.
43. Clayburgh, D.R., T.A. Barrett, Y. Tang, et al. 2005. Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J. Clin. Invest. 115: 2702-2715.
44. Chatenoud, L., C. Ferran & J.F. Bach. 1991. The antiCD3-induced syndrome: a consequence of massive in vivo cell activation. Curr. Top. Microbiol. Immunol. 174: 121-134.
45. Shen, L., E.D. Black, E.D. Witkowski, et al. 2006. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J. Cell Sci. 119: 2095-2106.
46. Turner, J.R., B.K. Rill, S.L. Carlson, et al. 1997. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am. J. Physiol. 273: C1378-1385.
47. +-glucose cotransport. Am. J. Physiol. - Gastrointest. Liver Physiol. 281: G1487-1493.
48. Shen, L. & J.R. Turner. 2005. Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis. Mol. Biol. Cell. 16: 3919-3936.
49. Schwarz, B.T., F. Wang, L. Shen, et al. 2007. LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterol. 132: 2383-2394.
50. Matsuda, M., A. Kubo, M. Furuse, et al. 2004. A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells. J. Cell Sci. 117: 1247- 1257.
51. Riesen, F.K., B. Rothen-Rutishauser & H. Wunderli-Allenspach. 2002. A ZO1-GFP fusion protein to study the dynamics of tight junctions in living cells. Histochem. Cell Biol. 117: 307-315.
52. Sasaki, H., C. Matsui, K. Furuse, et al. 2003. Dynamic behavior of paired claudin strands within apposing plasma membranes. Proc. Natl. Acad. Sci. USA 100: 3971-3976.
53. Shen, L., C.R. Weber & J.R. Turner. 2008. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J. Cell Biol. 181: 683-695.
54. Gonzalez-Mariscal, L., B. Chavez de Ramirez & M. Cereijido. 1984. Effect of temperature on the occluding junctions of monolayers of epithelioid cells (MDCK). J. Membr. Biol. 79: 175-184.
55. Piontek, J., L. Winkler, H. Wolburg, et al. 2008. Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J. 22: 146-158.
56. Shen, L. & J.R. Turner. 2006. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am. J. Physiol. - Gastrointest. Liver Physiol. 290: G577-582.
57. Taylor, C.T., A.L. Dzus & S.P. Colgan. 1998. Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha. Gastroenterol. 114: 657-668.
58. Bentzel, C.J., B. Hainau, S. Ho, et al. 1980. Cytoplas-mic regulation of tight-junction permeability: effect of plant cytokinins. Am. J. Physiol. 239: C75-89.
59. Madara, J.L. 1983. Increases in guinea pig small intestinal transepithelial resistance induced by osmotic loads are accompanied by rapid alterations in absorptive-cell tight-junction structure. J. Cell Biol. 97: 125-136.
60. Madara, J.L., R. Moore & S. Carlson. 1987. Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am. J. Physiol. 253: C854-C861.