Regulation of the intestinal anion exchanger dRA (Downregulated in Adenoma)

Annals of the New York Academy of Sciences

Volumn 1165, Issue , 2009, Pages 261-266

  Lamprecht, Georg ^a   Gaco, Vera ^a   Turner, Jerrold R ^b   Natour, Dorgam ^a   Gregor, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Calcium; cAMP; CFTR; DRA; E3KARP; Intestine; NHE3; NHERF; PDZ domain; PDZK1; SLC26A3

Indexed keywords

ADAPTOR PROTEIN; BICARBONATE CHLORIDE ANTIPORTER; CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRA PROTEIN; INTESTINAL AND KIDNEY ENRICHED PDZ PROTEIN; PDZ PROTEIN KIDNEY 1; PROTEIN KINASE C; SODIUM HYDROGEN EXCHANGER ISOFORM 3 KINASE A REGULATORY PROTEIN; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR; SODIUM PROTON EXCHANGE PROTEIN 3; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANION EXCHANGE; ARTICLE; CALCIUM CELL LEVEL; HUMAN; INTESTINE; PDZ DOMAIN; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN EXPRESSION; UPPER GASTROINTESTINAL TRACT;

EID: 67249112231     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04044.x     Document Type: Article

References (42)

1. Mount, D.B. & M.F. Romero. 2004. The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch. 447: 710-721.
2. Moseley, R.H., P. Hoglund, G.D. Wu, et al. 1999. Downregulated in adenoma gene encodes a chloride transporter defective in congenital chloride diarrhea. Am. J. Physiol. 276: G185-G192.
3. + exchanger. J. Biol.Chem. 274: 22855-22861.
4. Lamprecht, G., S. Baisch, E. Schoenleber & M. Gre-gor. 2005. Transport properties of the human intestinal anion exchanger DRA (down regulated in adenoma) in transfected HEK293 cells. Pflugers Arch. 449: 479-490.
5. Chernova, M.N., L. Jiang, B.E. Shmukler, et al. 2003. Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J. Physiol. (Lond). 549: 3-19.
6. Hoglund, P., S. Haila, J. Socha, et al. 1996. Mutations of the Down-regulated in adenoma (DRA)genecause congenital chloride diarrhoea. Nat. Genet. 14: 316- 319.
7. 3 exchanger in the lower villous epithelium of murine duodenum. Gastroenterology 130: A374. [Abstract]
8. 3 exchange in rabbit, rat, and human duodenum. Gastroenterology 122: 709-724.
9. 3- transport in cystic fibrosis. The EMBO Journal 21: 5662-5672.
10. Wang, Z., T. Wang, S. Petrovic, et al. 2005. Renal and intestinal transport defects in Slc26a6-null mice. Am. J. Physiol. 288: C957-C965.
11. Lohi, H., G. Lamprecht, D. Markovich, et al. 2003. Isoforms of the anion exchanger SLC26A6 (PAT1) mediate anion transport and have functional PDZ interaction domains. Am. J. Physiol. 284:C769-C779.
12. 3 exchange to Na/H exchange. Biochemistry 41: 12336-12342.
13. Schweinfest, C.W., D.D. Spyropoulos, K.W. Henderson, et al. 2006. slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon. J. Biol. Chem. 281: 37962-37971.
14. + exchanger. Nat. Genet. 19: 282-285.
15. Ko, S.B., W. Zeng, M.R. Dorwart, et al. 2004. Gating of CFTR by the STAS domain of SLC26 transporters. Nat. Cell Biol. 6: 343-350.
16. Lamprecht, G. & U. Seidler. 2006. The emerging role of PDZ adapter proteins for regulation of intestinal ion transport. Am. J. Physiol. 291: G766-G777.
17. Gill, R.K., A. Borthakur, K. Hodges, et al. 2007. Mechanism underlying inhibition of intestinal apical Cl/OH exchange following infection with enteropathogenic E. coli. J. Clin. Invest. 117: 428- 437.
18. Knickelbein, R., P.S. Aronson, W. Atherton & J.W. Dobbins. 1983. Sodium and chloride transport across rabbit ileal brush border. I. Evidence for Na-H exchange. Am. J. Physiol. 245: G504-G510.
19. 3 exchange and mechanism of coupling. Am. J. Physiol. 249: G236-G245.
20. + exchangers stably expressed in a fibroblast cell line. J. Biol. Chem. 268: 25527-25535.
21. Lamprecht, G., J. Schaefer, K. Dietz & M. Gregor. 2006. Chloride and bicarbonate have similar affinities to the intestinal anion exchanger DRA (down regulated in adenoma). Pfluegers Archiv. 452: 307-315.
22. + exchanger NHE3 activity by cAMP-dependent protein kinase. phosphorylationdependent and -independent mechanisms. J. Biol. Chem. 272: 28672-28679.
23. Murtazina, R., O. Kovbasnjuk, N.C. Zachos, et al. 2007. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na/H exchanger regulatory factor 1 (NHERF1) null mice: cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J. Biol. Chem. 282: 25141- 25151.
24. Lamprecht, G., J. Schaefer & M. Gregor. 2006. The intestinal anion exchanger DRA (down regulated in adenoma) is inhibited by intracellular calcium by not by PMA. Gastroenterology 130: A-373 [Abstract]
25. Donowitz, M., B. Cha, N.C. Zachos, et al. 2005. NHERF family and NHE3 regulation. J. Physiol. 567: 3-11.
26. Yun, C.H.C., G. Lamprecht, D.V. Foster & A. Sidor. 1998. NHE3 Kinase A regulatory protein (E3KARP) binds the epithelial brush border Na/H exchanger, NHE3, and the cytoskeletal protein ezrin. J. Biol . Chem. 273: 25856-25863.
27. Lamprecht, G., E.J. Weinman & C.H. Yun. 1998. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J. Biol. Chem. 273: 29972-29978.
28. + exchanger, NHE3, requires an associated regulatory protein. Proc. Nat. Acad. Sci. USA 94: 3010- 3015.
29. + exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. J. Biol. Chem. 274: 24753- 24758.
30. + exchanger (NHE3) endocytosis via clathrin-coated vesicles. dependence on protein kinase a-mediated NHE3 phosphorylation. J. Biol. Chem. 276: 26906-26915.
31. Kunzelmann, K. & M. Mall. 2002. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol. Rev. 82: 245-289.
32. + exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha -actinin-4 complex for oligomerization and endocytosis. J. Biol.Chem. 277: 23714-23724.
33. 2+-dependent inhibition of NHE3 requires PKCα which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes. Am. J. Physiol. 285: C1527-C1536.
34. + exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent. J. Physiol. (Lond). 556: 791-804.
35. Cinar, A., M. Chen, B. Riederer, et al. Differential effects of PDZ-adapterprotein NHERF1, E3KARP and PDZK1 knockout on the regulation of NHE3 transport activity in native murine colonic epithelium. Gastroenterology 130: A-99 [Abstract]
36. 2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes. J. Physiol. (Lond). 581: 1235-1246.
37. 2+]i. Gastroenterology 130: A-51. [Abstract]
38. 2+: inhibition with PDZk1 and stimulation with IKEPP. Gastroenterology 128: A-32. [Abstract]
39. 3 exchanger DRA in rabbit small intestinal mucosa. Biochemistry 44: 4477-4487.
40. Bucheimer, R.E. & J. Linden. 2004. Purinergic regulation of epithelial transport. J. Physiol. Online 555: 311-321.
41. Inoue, C.N., J.S. Woo, E.M. Schwiebert, et al. 1997. Role of purinergic receptors in chloride secretion in Caco-2 cells. Am. J. Physiol. 272: C1862-C1870.
42. Fischer, W., H. Franke, H. Groger-Arndt & P. Illes. 2005. Evidence for the existence of P2Y1,2,4 receptor subtypes in HEK-293 cells: reactivation of P2Y1 receptors after repetitive agonist application. Arch. Pharmacol. 371: 466-472.