In GERD patients, mucosal repair associated genes are upregulated in non-inflamed oesophageal epithelium

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 5, 2009, Pages 936-947

  De Vries, D R ^a   Ter Linde, J J M ^a   Van Herwaarden, M A ^b   Schwartz, M P ^c   Shephard, P ^d   Geng, M M ^d   Smout, A J P M ^a   Samsom, M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b DEVENTER HOSPITAL   (Netherlands)

^c MEANDER MEDICAL CENTER   (Netherlands)

^d ALTANA Pharma Nycomed   (Germany)

Author keywords

Epithelial restitution; Gastroesophageal reflux disease; Microarray expression profiling; Oesophageal epithelial defense; Oesophagus

Indexed keywords

ADULT; AGED; ARTICLE; DNA MICROARRAY; ESOPHAGUS; FEMALE; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; MALE; METABOLISM; MIDDLE AGED; MUCOSA; UPREGULATION;

ADULT; AGED; ESOPHAGUS; FEMALE; GASTROESOPHAGEAL REFLUX; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; MUCOUS MEMBRANE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; UP-REGULATION;

EID: 67249101109     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00626.x     Document Type: Article

References (56)

1. Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, Sonnenberg A, Stanghellini V, Stewart WF, Tack J, Talley NJ, Whitehead W, Revicki DA. Prevalence and socioeco-nomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005 3 : 543 52.
2. Dent J, El Serag HB, Wallander MA, Johansson S. Epidemiology of gastrooesophageal reflux disease: a systematic review. Gut. 2005 54 : 710 7.
3. Ronkainen J, Aro P, Storskrubb T, Lind T, Bolling-Sternevald E, Junghard O, Talley NJ, Agreus L. Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population - the Kalixanda study. Aliment Pharmacol Ther. 2006 23 : 1725 33.
4. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut. 1995 37 : 7 12.
5. Fass R, Naliboff B, Higa L, Johnson C, Kodner A, Munakata J, Ngo J, Mayer EA. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology. 1998 115 : 1363 73.
6. Holzer P. Sensory neurone responses to mucosal noxae in the upper gut: relevance to mucosal integrity and gastrointestinal pain. Neurogastroent Motil. 2002 14 : 459 75.
7. Fitzgerald RC, Onwuegbusi BA, Bajaj-Elliott M, Saeed IT, Burnham WR, Farthing MJG. Diversity in the oesophageal phenotypic response to gastro-oesophageal reflux: immunological determinants. Gut. 2002 50 : 451 9.
8. Hamoui N, Peters JH, Schneider S, Uchida K, Yang DY, Valboehmer D, Hagen JA, DeMeester SR, DeMeester TR, Danenberg K, Danenberg P. Increased acid exposure in patients with gastroesophageal reflux disease influences cyclooxygenase-2 gene expression in the squamous epithelium of the lower esophagus. Arch Surg. 2004 139 : 712 7.
9. Matthews P, Aziz Q, Facer P, Davis J, Thompson D, Anand P. Increased expression of the capsaicin receptor TRPV1 in the inflamed human esophagus. Gastroenterology. 2004 126 : A427.
10. Souza RF, Shewmake KL, Shen Y, Ramirez RD, Bullock JS, Hladik CL, Lee EL, Terada LS, Spechler SJ. Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus. Am J Gastroenterol. 2005 100 : 551 9.
11. Yoshida N, Uchiyama K, Kuroda M, Sakuma K, Kokura S, Ichikawa H, Naito Y, Takemura T, Yoshikawa T, Okanoue T. Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease. Scand J Gastroenterol. 2004 39 : 816 22.
12. Isomoto H, Saenko VA, Kanazawa Y, Nishi Y, Ohtsuru A, Inoue K, Akazawa Y, Takeshima F, Omagari K, Miyazaki M, Mizuta Y, Murata I, Yamashita S, Kohno S. Enhanced expression of interleukin-8 and activation of nuclear factor kappa-B in endoscopy-negative gastroesophageal reflux disease. Am J Gastroenterol. 2004 99 : 589 97.
13. Orlando RC. Oesophageal mucosal resistance. Aliment Pharmacol Ther. 1998 12 : 191 7.
14. Takubo K, Honma N, Aryal G, Sawabe M, Arai T, Tanaka Y, Mafune K. Is there a set of histologic changes that are invariably reflux associated? Arch Pathol Lab Med. 2005 129 : 159 63.
15. Vieth M, Fiocca R, Haringsma J, Delarive J, Wiesel PH, Tam W, Tytgat GNJ, Dent J, Edebo A, Lundell L, Stolte M. Radial distribution of dilated intercellular spaces of the esophageal squamous epithelium in patients with reflux disease exhibiting discrete endoscopic lesions. Digest Dis. 2004 22 : 208 12.
16. Weusten B, Akkermans L, van Berge-Henegouwen G, Smout A. Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics. Gastroenterology. 1995 108 : 1739 44.
17. Weusten BL, Akkermans LM, van Berge-Henegouwen GP, Smout AJ. Spatiotemporal characteristics of physiological gastroesophageal reflux. Am J Physiol Gastrointest Liver Physiol. 1994 266 : G357 62.
18. Talley NJ, Verlinden M, Jones M. Validity of a new quality of life scale for functional dyspepsia: a United States multicenter trial of the Nepean Dyspepsia Index. Am J Gastroenterol. 1999 94 : 2390 7.
19. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002 3 : RESEARCH0034.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001 25 : 402 8.
21. Mammen JM, Matthews JB. Mucosal repair in the gastrointestinal tract. Crit Care Med. 2003 31 : S532 7.
22. Lacy ER, Ito S. Rapid epithelial restitution of the rat gastric mucosa after ethanol injury. Lab Invest. 1984 51 : 573 83.
23. Takahashi N, Joh T, Yokoyama Y, Seno K, Nomura T, Ohara H, Ueda F, Itoh M. Importance of gap junction in gastric mucosal restitution from acid-induced injury. J Lab Clin Med. 2000 136 : 93 9.
24. Solan JL, Lampe PD. Connexin phospho-rylation as a regulatory event linked to gap junction channel assembly. Biochim Biophys Acta. 2005 1711 : 154 63.
25. Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M. Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. J Biol Chem. 2002 277 : 50612 20.
26. Gassmann MG, Stanzel A, Werner S. Growth factor-regulated expression of enzymes involved in nucleotide biosynthesis: a novel mechanism of growth factor action. Oncogene. 1999 18 : 6667 76.
27. Izeradjene K, Douglas L, Delaney AB, Houghton JA. Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex. Cancer Res. 2004 64 : 8036 44.
28. Machida K, Ohta Y, Osada H. Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochon-drial binding in cancer cells. J Biol Chem. 2006 281 : 14314 20.
29. Nomura J, Matsumoto K, Iguchi-Ariga SM, Ariga H. Mitochondria-independent induction of Fas-mediated apoptosis by MSSP. Oncol Rep. 2005 14 : 1305 9.
30. Affaitati A, Cardone L, De CT, Carlucci A, Ginsberg MD, Varrone S, Gottesman ME, Avvedimento EV, Feliciello A. Essential role of A-kinase anchor protein 121 for cAMP signaling to mitochondria. J Biol Chem. 2003 278 : 4286 94.
31. Pomerantz JL, Baltimore D. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 1999 18 : 6694 704.
32. Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci USA 1996 93 : 8241 6.
33. Germain M, Duronio V. The N terminus of the anti-apoptotic BCL-2 homologue MCL-1 regulates its localization and function. J Biol Chem. 2007 282 : 32233 42.
34. Chao CH, Chen CM, Cheng PL, Shih JW, Tsou AP, Lee YH. DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1-cip1 promoter, is a candidate tumor suppressor. Cancer Res. 2006 66 : 6579 88.
35. Nikolaev AY, Papanikolaou NA, Li M, Qin J, Gu W. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A-p33(ING1b)-HDAC1 deacetylase complex. Biochem Biophys Res Commun. 2004 323 : 1216 22.
36. Harel A, Forbes DJ. Importin beta: conducting a much larger cellular symphony. Mol Cell. 2004 16 : 319 30.
37. Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, Kose S, Imamoto N. Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid. J Cell Biol. 2008 180 : 493 506. (Pubitemid 351240699)
38. Bailey CM, Abbott DE, Margaryan NV, Khalkhali-Ellis Z, Hendrix MJ. IRF6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. Mol Cell Biol. 2008 28 : 2235 43.
39. Miller SA, Brown AJ, Farach-Carson MC, Kirn-Safran CB. HIP-RPL29 down-regulation accompanies terminal chondrocyte differentiation. Differentiation. 2003 71 : 322 36.
40. Wetscher GJ, Hinder RA, Bagchi D, Hinder PR, Bagchi M, Perdikis G, McGinn T. Reflux esophagitis in humans is mediated by oxygen-derived free radicals. Am J Surg. 1995 170 : 552 6.
41. Yoon KA, Nakamura Y, Arakawa H. Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. J Hum Genet. 2004 49 : 134 40.
42. Vasiliou V, Pappa A, Estey T. Role of human aldehyde dehydrogenases in endo-biotic and xenobiotic metabolism. Drug Metab Rev. 2004 36 : 279 99.
43. Thornalley PJ. Glyoxalase I-structure, function and a critical role in the enzymatic defence against glycation. Biochem Soc Trans. 2003 31 : 1343 8.
44. Schroder-Kohne S, Letourneur F, Riezman H. Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport. J Cell Sci. 1998 111 : 3459 70.
45. Feurle GE. Xenin-a review. Peptides. 1998 19 : 609 15.
46. Theodorsson-Norheim E, Thor K, Rosell S. Relation between lower esophageal sphincter (LES) pressure and the plasma concentration of neurotensin during intravenous infusion of neurotensin(1-13) and (Gln4)neurotensin(1-13) in man. Acta Physiol Scand Suppl. 1983 515 : 29 35.
47. Paulusma CC, Folmer DE, Ho-Mok KS, de Waart DR, Hilarius PM, Verhoeven AJ, Oude Elferink R P. ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity. Hepatology. 2008 47 : 268 78.
48. Bredenoord AJ, Weusten BLAM, Curvers WL, Timmer R, Smout AJPM. Determinants of perception of heartburn and regurgitation. Gut. 2006 55 : 313 8.
49. Schey R, Shapiro M, Navarro-Rodriguez T, Fass SS, Han B, Wendel C, Fass R. Comparison of the different characteristics of sensed reflux events among different heartburn groups. J Clin Gastroenterol. 2008 doi :.
50. ® probe-based assays for human and other model organism genes. Appl Biosyst. 2006.
51. Jimenez P, Lanas A, Piazuelo E, Esteva F. Effect of growth factors and prostaglandin E2 on restitution and proliferation of rabbit esophageal epithelial cells. Dig Dis Sci. 1998 43 : 2309 16.
52. Jimenez P, Lanas A, Piazuelo E, Esteva F. Effects of extracellular pH on restitution and proliferation of rabbit oesophageal epithelial cells. Aliment Pharmacol Ther. 1999 13 : 545 52.
53. Tobey NA, Powell DW, Schreiner VJ, Orlando RC. Serosal bicarbonate protects against acid injury to rabbit esophagus. Gastroenterology. 1989 96 : 1466 77.
54. Yoshida N, Kuroda M, Uchiyama K, Suzuki T, Okuda T, Tuboi H, Kajikawa H, Handa O, Kokura S, Ichikawa H, Naito Y, Yoshikawa T, Okanoue T. Microarray analysis of transcriptome in patients with non-erosive reflux disease. Gastroenterology. 2005 128 : A1 A821.
55. Zentilin P, Savarino V, Mastracci L, Spaggiari P, Dulbecco P, Ceppa P, Savarino E, Parodi A, Mansi C, Fiocca R. Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group. Am J Gastroenterol. 2005 100 : 2299 306.
56. Ostrowski J, Rubel T, Wyrwicz LS, Mikula M, Bielasik A, Butruk E, Regula J. Three clinical variants of gastroe-sophageal reflux disease form two distinct gene expression signatures. J Mol Med. 2006 84 : 872 82.