Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group

American Journal of Gastroenterology

Volumn 100, Issue 10, 2005, Pages 2299-2306

  Zentilin, Patrizia ^a   Savarino, Vincenzo ^a   Mastracci, Luca ^a   Spaggiari, Paola ^a   Dulbecco, Pietro ^a   Ceppa, Paola ^a   Savarino, Edoardo ^a   Parodi, Andrea ^a   Mansi, Carlo ^a   Fiocca, Roberto ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BASAL CELL; CELL HYPERPLASIA; CELL INFILTRATION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EOSINOPHIL; EROSION; ESOPHAGITIS; ESOPHAGUS BIOPSY; ESOPHAGUS PH; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL ENDOSCOPY; HISTOLOGY; HUMAN; HUMAN TISSUE; INTERCELLULAR SPACE; MAJOR CLINICAL STUDY; MALE; NECROSIS; NEUTROPHIL CHEMOTAXIS; NONEROSIVE REFLUX DISEASE; PH MEASUREMENT; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; STOMACH BIOPSY; SYMPTOM; BIOPSY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSS-SECTIONAL STUDY; ESOPHAGUS; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; REPRODUCIBILITY; ROC CURVE; STOMACH PH;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CROSS-SECTIONAL STUDIES; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGUS; FEMALE; GASTRIC ACIDITY DETERMINATION; GASTROESOPHAGEAL REFLUX; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; ROC CURVE;

EID: 27744503217     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.50209.x     Document Type: Article

References (37)

1. Locke GR Talley NJ Fett SL, et al. Prevalence and clinical spectrum of gastresophageal reflux: A population based study in Olmsted County, Minnesota. Gastroenterology 1997 112 : 1448 56.
2. Stanghellini V Cogliandro R Cogliandro L, et al. Unsolved problems in the management of patients with gastro-esophageal reflux disease. Dig Liver Dis 2003 35 : 843 8.
3. Stanghellini V Armstrong D Monnikes H, et al. Systematic review: Do we need a new gastro-esophageal reflux disease questionnaire? Aliment Pharmacol Ther 2004 19 : 463 79.
4. Schindlbeck NE Klauser AG Berghammer G, et al. Three year follow-up of patients with gastresophageal reflux disease. Gut 1992 33 : 1016 9.
5. Johnsson F Weywadt L Solhaug JH, et al. One-week omeprazole treatment in the diagnosis of gastro-esophageal reflux disease. Scand J Gastroenterol 1998 33 : 15 20.
6. Quigley EM. 24-h pH monitoring for gastresophageal reflux disease: Already standard but not yet gold? Am J Gastroenterol 1992 87 : 1071 5.
7. Ismail-Beigi F Horton PF Pope CE. Histological consequences of gastresophageal reflux in man. Gastroenterology 1970 58 : 163 74.
8. Behar J Sheahan DC. Histological abnormalities in reflux esophagitis. Arch Pathol 1975 99 : 387 91.
9. Weinstein WM Bogoch ER Bowes KL. The normal human esophageal mucosa: A histological reappraisal. Gastroenterology 1975 68 : 40 4.
10. Seefeld U Krejs GJ Siebenmann RE, et al. Esophageal histology in gastresophageal reflux. Morphometric findings in suction biopsies. Dig Dis Sci 1977 22 : 956 64.
11. Collins BJ Elliott H Sloan JM, et al. Esophageal histology in reflux esophagitis. J Clin Pathol 1985 38 : 1265 72.
12. Schindlbeck NE Wiebecke B Klauser AG, et al. Diagnostic value of histology in non-erosive gastro-esophageal reflux disease. Gut 1996 39 : 151 1544.
13. Kasapidis P Xynos E Mantides A, et al. Differences in manometry and 24-h ambulatory pH-metry between patients with and without endoscopic or histological esophagitis in gastresophageal reflux disease. Am J Gastroenterol 1993 88 : 1893 9.
14. Nandurkar S Talley NJ Martin CJ, et al. Esophageal histology does not provide additional useful information over clinical assessment in identifying reflux patients presenting for esophagogastroduodenoscopy. Dig Dis Sci 2000 45 : 217 24.
15. Narayani RI Burton MP Young GS. Utility of esophageal biopsy in the diagnosis of nonerosive reflux disease. Dis Esophagus 2003 16 : 187 92.
16. Dent J Brun J Fendrick AM, et al. on behalf of the Genval Workshop Group. An evidence-based appraisal of reflux disease management - The Genval workshop report. Gut 1999 44 ( Suppl 2 S1 16.
17. Solcia E Villani L Luinetti O, et al. Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease. Virchows Arch 2000 436 : 207 16.
18. Villanacci V Grigolato PG Cestari R, et al. Dilated intercellular spaces as marker of esophageal reflux: Histology, semiquantitative score and morphometry upon light microscopy. Digestion 2001 64 : 1 8.
19. Caviglia R Ribolsi M Maggiano N, et al. Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure. Am J Gastroenterol 2005 100 : 543 8.
20. Calabrese C Bortolotti M Fabbri A, et al. Reversibilità of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment. Am J Gastroenterol 2005 100 : 537 42.
21. Carlsson R Dent J Bolling-Sternevald E, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastresophageal reflux disease. Scand J Gastroenterol 1998 33 : 1023 9.
22. Armstrong D Bennett JR Blum AL, et al. The endoscopic assessment of esophagitis: A progress report on observer agreement. Gastroenterology 1996 111 : 85 92.
23. Zentilin P Conio M Mele MR, et al. Comparison of the main esophageal pathophysiological characteristics between short- and long-segment Barrett's oesophagus. Aliment Pharmacol Ther 2002 16 : 893 8.
24. Mela GS Savarino V Vigneri S. Optimizing the information obtained from continuous 24-hour gastric pH monitoring. Am J Gastroenterol 1992 87 : 961 6.
25. Johnson LF DeMeester TR. Twenty-four hour pH monitoring of the distal esophagus. A quantitative measure of gastresophageal reflux. Am J Gastroenterol 1974 62 : 325 32.
26. Kahrilas PJ Quigley EM. Clinical esophageal pH recording: A technical review for practice guideline development. Gastroenterology 1996 110 : 1982 96.
27. Fleiss JL Cohen J. The equivalence of weighted kappa and the intraclass correlation coefficient as measures of reliability. Educ Psychol Meas 1973 33 : 613 9.
28. Funch-Jensen P Kock K Christensen LA, et al. Microscopic appearance of the esophageal mucosa in a consecutive series of patients, submitted to upper endoscopy. Correlation with gastresophageal reflux symptoms and macroscopic findings. Scand J Gastroenterol 1986 21 : 65 9.
29. Vieth M Peitz U Labenz J, et al. What parameters are relevant for the histological diagnosis of gastresophageal reflux disease without Barrett's mucosa? Dig Dis 2004 22 : 196 201.
30. Steiner SJ Gupta SK Croffie JM, et al. Correlation between number of eosinophils and reflux index on the same day esophageal biopsy and 24-hour esophageal pH monitoring. Am J Gastroenterol 2004 99 : 801 5.
31. Tobey NA Carson JL Alkiek RA, et al. Dilated intercellular spaces: A morphological feature of acid reflux - Damaged human esophageal epithelium. Gastroenterology 1996 111 : 1200 5.
32. Armstrong D Vieth M Fiocca R, et al. Esomeprazole therapy and esophageal histology in endoscopy-negative reflux disease (ERND) - The CHEER study [Abstract]. Gastroenterology 2004 124 ( Suppl 1 A416.
33. Kiesslich R Kauzler S Vieth M, et al. Minimal change esophagitis: Prospective comparison of endoscopic and histological markers between patients with non-erosive reflux disease and normal controls using magnifying endoscopy. Dig Dis 2004 22 : 221 7.
34. Tutuian R Vela M Shay SS, et al. Multichannel intraluminal impedance in esophageal function testing and gastresophageal reflux monitoring. J Clin Gastroenterol 2003 37 : 206 15.
35. Zentilin P Dulbecco P Savarino E, et al. Combined multichannel intraluminal impedance and pH-metry: A novel technique to improve detection of gastro-esophageal reflux. Literature review. Dig Liver Dis 2004 36 : 565 9.
36. Fass R Tougas G. Functional heartburn: The stimulus, the pain, the brain. Gut 2002 51 : 885 92.
37. Frazzoni M De Micheli E Zentilin P, et al. Pathophysiological characteristics of patients with non-erosive reflux disease differ from those of patients with functional heartburn. Aliment Pharmacol Ther 2004 20 : 81 8.