Heck-type benzylation of olefins with benzyl trifluoroacetates

Chemistry Letters

Volumn 33, Issue 3, 2004, Pages 348-349

  Narahashi, Hirohisa ^a   Yamamoto, Akio ^a   Shimizu, Isao ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; BENZYL DERIVATIVE; CARBOXYLIC ACID; OXYGEN; PALLADIUM; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TRIFLUOROACETIC ACID;

ARTICLE; BENZYLATION; CATALYST; CHEMICAL BOND; OXIDATION; SYNTHESIS;

EID: 2442665166     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2004.348     Document Type: Article

References (19)

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18. 2] (1.66 mmol) and styrene (5.24 mmol) were added at -20°C. On standing the mixture at 50°C for 2 h, the solution became a homogeneous yellow solution. After cooling this solution at room temperature, benzyl trifluoroacetate (2.02 mmol) was added to this solution and the solution was stirred at room temperature for 3 h. After the reaction mixture was concentrated, hexane was added to precipitate 2, which was filtrated and collected. Subsequent washing with hexane and drying in vacuo gave a pale white powder of 2 (1.54 mmol, 93% yield).
19. 4 and the solvent was evaporated in vacuo. Purification of the residue by column chromatography (hexane/ ethyl acetate) gave the benzylation compound.