The Dynamic Tumor Bed: Volumetric Changes in the Lumpectomy Cavity During Breast-Conserving Therapy

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 3, 2009, Pages 695-701

  Prendergast, Brendan ^a   Indelicato, Daniel J ^b   Grobmyer, Stephen R ^a   Saito, Anneyuko I ^c   Lightsey, Judith L ^a   Snead, Felicia E ^b   Morris, Christopher G ^a   Copeland, Edward M ^a   Mendenhall, Nancy P ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Breast conservation; Lumpectomy; Radiation Therapy; Volume

Indexed keywords

AVERAGE RATE; BREAST CANCER; BREAST CONSERVATION; BREAST-CONSERVING THERAPY; COMPUTED TOMOGRAPHY SCAN; LUMPECTOMY; POST-OPERATIVE DAYS; RADIATION THERAPY; RATE OF CHANGE; SURGICAL CLIPS; TREATMENT PLANNING; TUMOR BED; VOLUME; VOLUME CHANGE; VOLUMETRIC CHANGES;

COMPUTERIZED TOMOGRAPHY; RADIOTHERAPY; SURGERY; TOMOGRAPHY;

TUMORS;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; HUMAN; PARTIAL MASTECTOMY; PRIORITY JOURNAL; RADIATION DOSE; TREATMENT PLANNING; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; OBSERVER VARIATION; REMISSION INDUCTION; SEROMA; SURGICAL INSTRUMENTS; TOMOGRAPHY, X-RAY COMPUTED; TUMOR BURDEN;

EID: 67049172717     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.08.044     Document Type: Article

References (31)

1. Blichert-Toft M., Rose C., Andersen J.A., et al. Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst Monogr (1992) 19-25
2. Jacobson J.A., Danforth D.N., Cowan K.H., et al. Ten-year results of a comparison of conservation with mastectomy in the treatment of Stage I and II breast cancer. N Engl J Med 332 (1995) 907-911
3. Fisher B., Anderson S., Bryant J., et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347 (2002) 1233-1241
4. Bartelink H., Horiot J.C., Poortmans P.M., et al. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-Year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol 25 (2007) 3259-3265
5. Clark R.M., Whelan T., Levine M., et al. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst 88 (1996) 1659-1664
6. Liljegren G., Holmberg L., Bergh J., et al. 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol 17 (1999) 2326-2333
7. Veronesi U., Marubini E., Mariani L., et al. Radiotherapy after breast-conserving surgery in small breast carcinoma: Long-term results of a randomized trial. Ann Oncol 12 (2001) 997-1003
8. Holli K., Saaristo R., Isola J., et al. Lumpectomy with or without postoperative radiotherapy for breast cancer with favourable prognostic features: results of a randomized study. Br J Cancer 84 (2001) 164-169
9. Romestaing P., Lehingue Y., Carrie C., et al. Role of a 10-Gy boost in the conservative treatment of early breast cancer: Results of a randomized clinical trial in Lyon, France. J Clin Oncol 15 (1997) 963-968
10. Landis D.M., Luo W., Song J., et al. Variability among breast radiation oncologists in delineation of the postsurgical lumpectomy cavity. Int J Radiat Oncol Biol Phys 67 (2007) 1299-1308
11. Petersen R.P., Truong P.T., Kader H.A., et al. Target volume delineation for partial breast radiotherapy planning: clinical characteristics associated with low interobserver concordance. Int J Radiat Oncol Biol Phys 69 (2007) 41-48
12. Pierce L.J., Moughan J., White J., et al. 1998-1999 Patterns of care study process survey of national practice patterns using breast-conserving surgery and radiotherapy in the management of Stage I-II breast cancer. Int J Radiat Oncol Biol Phys 62 (2005) 183-192
13. NSABPB-39, RTOG 0413: A Randomized Phase III Study of conventional whole breast irradiation versus partial breast irradiation for women with stage 0, I, or II breast cancer. Clin Adv Hematol Oncol 4 (2006) 719-721
14. Machtay M., Lanciano R., Hoffman J., et al. Inaccuracies in using the lumpectomy scar for planning electron boosts in primary breast carcinoma. Int J Radiat Oncol Biol Phys 30 (1994) 43-48
15. Regine W.F., Ayyangar K.M., Komarnicky L.T., et al. Computer-CT planning of the electron boost in definitive breast irradiation. Int J Radiat Oncol Biol Phys 20 (1991) 121-125
16. Denham J.W., Sillar R.W., and Clarke D. Boost dosage to the excision site following conservative surgery for breast cancer: it's easy to miss!. Clin Oncol (R Coll Radiol) 3 (1991) 257-261
17. Oh K.S., Kong F.M., Griffith K.A., et al. Planning the breast tumor bed boost: changes in the excision cavity volume and surgical scar location after breast-conserving surgery and whole breast irradiation. Int J Radiat Oncol Biol Phys 66 (2006) 680-686
18. Benda R.K., Yasuda G., Sethi A., et al. Breast boost: Are we missing the target?. Cancer 97 (2003) 905-909
19. Weed D.W., Yan D., Martinez A.A., et al. The validity of surgical clips as a radiographic surrogate for the lumpectomy cavity in image-guided accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 60 (2004) 484-492
20. Jacobson G., Betts V., and Smith B. Change in volume of lumpectomy cavity during external-beam irradiation of the intact breast. Int J Radiat Oncol Biol Phys 65 (2006) 1161-1164
21. Indelicato D., Grobmyer S.R., Newlin H., et al. Association between operative closure type and acute infection, local recurrence, and disease surveillance in patients undergoing breast conserving therapy for early-stage breast cancer. Surgery 141 (2007) 645-653
22. Indelicato D.J., Grobmyer S.R., Newlin H., et al. Delayed breast cellulitis: An evolving complication of breast conservation. Int J Radiat Oncol Biol Phys 66 (2006) 1339-1346
23. Smitt M.C., Birdwell R.L., and Goffinet D.R. Breast electron boost planning: Comparison of CT and US1. Radiology 219 (2001) 203-206
24. Nichols E.M., Flannery T.W., Markham K.M., et al. Repeat Computed Tomography Simulation to Assess Lumpectomy Cavity Volume During Whole Breast Irradiation. Int J Radiat Oncol Biol Phys 69 (2007) S221
25. Holland R., Veling S.H., Mravunae M., et al. Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials for breast-conserving surgery. Cancer 56 (1985) 979-990
26. Muller A., Tschahargane C., Anton H.W., et al. Multicentric primaries and residual tumor masses following wide excision in breast cancer: a basis for irradiation. Eur J Gynaecol Oncol 10 (1989) 310-318
27. Hurkmans C., Admiraal M., van der S.M., et al. Significance of breast boost volume changes during radiotherapy in relation to current clinical interobserver variations. Radiother Oncol (2008)
28. van der Laan H.P., Dolsma W.V., Maduro J.H., et al. Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy. Radiat Oncol 3 (2008) 6
29. Bellon J.R., Come S.E., Gelman R.S., et al. Sequencing of chemotherapy and radiation therapy for patients with early stage breast cancer: Updated results of a prospective randomized trial. [Abstr.] Int J Radiat Oncol Biol Phys 51 (2001) 2S-3S
30. Huang J., Barbera L., Brouwers M., et al. Does delay in starting treatment affect the outcomes of radiotherapy? A systematic review. J Clin Oncol 21 (2003) 555-563
31. Hebert-Croteau N., Freeman C.R., Latreille J., et al. A population-based study of the impact of delaying radiotherapy after conservative surgery for breast cancer. Breast Cancer Res Treat 88 (2004) 187-196