Propofol induces ERK-dependant expression of c-Fos and Egr-1 in neuronal cells

NeuroReport

Volumn 20, Issue 7, 2009, Pages 657-662

  Kidambi, Srivatsan ^a,b   Yarmush, Joel ^a   Fong, Wayne ^a   Kamath, Sangeetha ^a   Schianodicola, Joseph ^a   Nahmias, Yaakov ^b  

^a NEW YORK METHODIST HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

aminobutyric acid; Extracellular signal regulated kinase; Immediate early genes; Propofol

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; EARLY GROWTH RESPONSE FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PROPOFOL; PROTEIN C FOS; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; EGR1 PROTEIN, MOUSE; ENZYME INHIBITOR; FLAVONOID; GABAERGIC RECEPTOR AFFECTING AGENT;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; IMMEDIATE EARLY GENE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; CELL DEATH; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MOUSE; NERVE CELL; ONCOGENE; POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BICUCULLINE; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EARLY GROWTH RESPONSE PROTEIN 1; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GABA AGENTS; GABA ANTAGONISTS; GENES, FOS; MICE; NEURONS; POLYMERASE CHAIN REACTION; PROPOFOL; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GABA-A; TRANSCRIPTION, GENETIC;

EID: 67049171035     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328329a449     Document Type: Article

References (23)

1. Nagashima K, Zorumski CF, Izumi Y. Propofol inhibits long-term potentiation but not long-term depression in rat hippocampal slices. Anesthesiology 2005; 103:318-326.
2. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, et al. General a0nesthetic actions in vivo strongly attenuated by a point mutation in the GABA-A receptor beta 3 subunit. FASEB J 2003; 17:250-252.
3. Jones C, Griffiths RD, Humphris G. Disturbed memory and amnesia related to intensive care. Memory 2000; 8:79-94.
4. Perouansky M. General anesthetics and long-term neurotoxicity. Handb Exp Pharmacol 2008; 182:143-157.
5. Pang R, Quartermain D, Rosman E,Turndorf H. Effect of propofol on memory in mice. Pharmacol Biochem Behav 1993; 44:145-151.
6. Veselis RA, Feshchenko VA, Reinsel RA, Beattie B, Akhurst TJ. Propofol and thiopental do not interfere with regional cerebral blood flow response at sedative concentrations. Anesthesiology2005; 102:26-34.
7. Lanahan A, Worley P. Immediate-early genes and synaptic function. Neurobiol Learn Mem 1998; 70:37-43.
8. Abraham WC, Dragunow M, Tate WP. The role of immediate early genes in the stabilization of long-term potentiation. Mol Neurobiol 1991; 5:297-314.
9. Dragunow M. A role for immediate-early transcription factors in learning and memory. Behav Genet 1996; 26:293-299.
10. Fukuda K, Shoda T, Mima H, Uga H. Midazolam induces expression of c-Fos and EGR-1 by a non-GABAergic mechanism. Anesth Analg 2002; 95:373-378.
11. Jouvert P, Pain L, Aunis D, Zwiller J. The anesthetics propofol and ketamine inhibit cocaine-induced egr-1 gene expression in rat forebrain. Eur J Pharmacol 2002; 449:239-243.
12. Hamaya Y, Takeda T, Dohi S, Nakashima S, Nozawa Y. The effects of pentobarbital, isoflurane, and propofol on immediate-early gene expression in the vital organs of the rat. Anesth Analg 2000; 90:1177-1183.
13. Kubota I, Tsuboi Y, Shoda E, Kondo M, Masuda Y, Kitagawa J, et al. Modulation of neuronal activity in CNS pain pathways following propofol administration in rats: Fos and EEG analysis. Exp Brain Res 2007; 179:181-190.
14. Dickey CA, De Mesquita DD, Morgan D, Pennypacker KR. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neurosci Lett 2004; 366:10-14.
15. Stephanova E, Topouzova-Hristova T, Konakchieva R. Mitochondria are involved in stress response of A549 alveolar cells to halothane toxicity. Toxicol In Vitro 2008; 22:688-694.
16. Eckenhoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, et al. Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology 2004; 101:703-709.
17. Engdahl O, Abrahams M, Bjornsson A, Vegfors M, Norlander B, Ahlner J, Eintrei C. Cerebrospinal fluid concentrations of propofol during anesthesia in humans. Br J Anaesth 1998; 81:957-959.
18. Hales TG, Tyndale RF. Few cell lines with GABAA mRNAs have functional receptors. J Neurosci 1994; 14:5429-5436.
19. Widmann C, Gibson S, Jarpe MB, Johnson GL. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev 1999; 79:143-180.
20. Zheng S, Zuo Z. Isoflurane preconditioning induces neuroprotection against ischemia via activation of P38 mitogen-activated protein kinases. Mol Pharmacol 2004; 65:11 72-1180.
21. Dahmani S, Tesniere A, Rouelle D, Toutant M, Desmonts JM, Mantz J. Effects of anesthetic agents on focal adhesion kinase (pp125FAK) tyrosine phosphorylation in rat hippocampal slices. Anesthesiology2004; 101:344-353.
22. Kozinn J, Mao L, Arora A, Yang L, Fibuch EE, Wang JQ. Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol. Anesthesiology 2006; 105:1182-1191.
23. Hodge C, Liao J, Stofega M, Guan K, Carter-Su C, Schwartz J. Growth hormone stimulates phosphorylation and activation of Elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2. J Biol Chem 1998; 273:31327-31336.