Mitochondria are involved in stress response of A549 alveolar cells to halothane toxicity

Toxicology in Vitro

Volumn 22, Issue 3, 2008, Pages 688-694

  Stephanova, Elena ^a   Topouzova Hristova, Tanya ^a   Konakchieva, Rossitza ^b  

^a UNIVERSITY OF SOFIA   (Bulgaria)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

Author keywords

Apoptosis; Bcl 2; DNA damage; Halothane; Lung cells

Indexed keywords

DNA; HALOTHANE; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); DNA DAMAGE; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; MITOCHONDRION; PROTEIN EXPRESSION; STRESS;

ANESTHETICS, INHALATION; APOPTOSIS; CELL LINE; CELL SURVIVAL; DNA DAMAGE; GENES, BCL-2; HALOTHANE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICROSCOPY, ELECTRON; MITOCHONDRIA; PULMONARY ALVEOLI; SIGNAL TRANSDUCTION; STRESS;

EID: 40049096177     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.12.012     Document Type: Article

References (27)

1. L in peroxide-resistant A549 and U87MG cells. Toxicological Sciences 42 (1998) 109-116
2. Burlacu A. Regulation of apoptosis by Bcl-2 family proteins. Journal of Cellular and Molecular Medicine 7 3 (2003) 249-257
3. Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends in Cell Biology 10 (2000) 369-377
4. Eckenhoff R.G., and Shuman H. Subcellular distribution of an inhalational anesthetic in situ. Proceedings of the National Academy of Sciences of the United States of America 87 1 (1990) 454-457
5. Franks N.P., and Lieb W.R. Molecular and cellular mechanisms of general anaesthesia. Nature 367 (1994) 607-614
6. Fujita T., Maruyama M., Araya J., Sassa K., Kawadishi Y., Hayashi R., Matsui S., Kashii T., Yamashita N., Sugiyama E., and Kobayashi M. Hydrogen peroxide induces upregulation of Fas in human airway epithelial cells via the activation of PARP-p53 pathway. American Journal of Respiratory Cell and Molecular Biology 27 (2002) 542-552
7. Gao Z., Shao Y., and Jiang X. Essential roles of Bcl-2 family of proteins in caspase-2-induced apoptosis. The Journal of Biological Chemistry 280 46 (2005) 38271-38275
8. Herr I., and Debatin K.M. Cellular stress response and apoptosis in cancer therapy. Blood 98 9 (2001) 2603-2614
9. Holaday D.A. Absorption, biotransformation and storage of halothane. Environmental Health Perspectives 21 (1977) 165-169
10. Jaloszynski P., Kujawski M., Wasowicz M., Szulc R., and Szyfter K. Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using the comet assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 439 2 (1999) 199-206
11. Karpiñski T.M., Kostrzewska-Poczekaj M., Stachecki I., Mikstacki A., and Szyfter K. Genotoxicity of the volatile anaesthetic desflurane in human lymphocytes in vitro, established by comet assay. Journal of Applied Genetics 46 3 (2005) 319-324
12. Lestari F., Hayes A.J., Green A.R., and Markovic B. In vitro cytotoxicity of selected chemicals commonly produced during fire combustion using human cell lines. Toxicology in Vitro 19 5 (2005) 653-663
13. Lieber M., Smith B., Szakal A., Nelson-Rees W., and Rodaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. International Journal of Cancer 17 (1976) 62-70
14. 2+-ATPases?. The Journal of Biological Chemistry 270 47 (1995) 28239-28245
15. Lu Q., Harrington E.O., and Rounds S. Apoptosis and lung injury. Kejo Journal of Medicine 54 4 (2005) 184-189
16. Rithalia A., Qureshi M.A., Howarth F.C., and Harrison S.M. Effect of halothane on contraction and intracellular calcium in ventricular myocytes from streptozotocin-induced diabetic rats. British Journal of Anaesthesia 92 2 (2004) 246-253
17. - channel activities in cultured human alveolar epithelial cells. Molecular Pharmacology 69 5 (2006) 1755-1762
18. Smuszkiewicz P., Drobnik L., Mieszkowski J., Konikowski A., Holyñska I., Kaczorowski P., and Tyrakowski T. Comparison of the influence of halothane and isoflurane on airway transepithelial potential difference. Pharmacological Reports 58 (2006) 736-745
19. Stimson L.M., Vattulainen I., Ryg T., and Karttunen M. Exploring the effect of xenon on biomembranes. Cellular and Molecular Biology Letters 10 (2005) 563-569
20. Szyfter K., Szulc R., Mikstacki A., Stachecki I., Rydzanicz M., and Jaloszynski P. Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo. Journal of Applied Genetics 45 3 (2004) 369-374
21. Topouzova-Hristova T., Daza P., Herdugo G., and Stephanova E. Volatile anaesthetic halothane causes DNA damage in A549 lung cells. Toxicology in Vitro 20 5 (2006) 585-593
22. Topouzova-Hristova T., Hazarosova R., Bandreva B., and Stephanova E. Halothane does not directly interact with genome DNA of A549 cells. Folia Biologica (Praha) 53 (2007) 176-182
23. Trudell J.R., and Bertaccini E. Molecular modelling of specific and non-specific anaesthetic interactions. British Journal of Anaesthesia 89 1 (2002) 32-40
24. Valtcheva R., Stephanova E., Jordanova A., Pancov R., Altankov G., and Lalchev Z. Effect of halothane on lung carcinoma cells A549. Chemico-Biological Interactions 146 (2003) 191-200
25. Watanabe N., Dickinson D.A., Krzywanski D.M., Iles K.E., Zhang H., Venglarik C.J., and Forman H.J. A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. American Journal of Physiology: Lung Cellular and Molecular Physiology 283 (2002) L726-L736
26. 2+ cytochemical changes of hepatotoxicity caused by halothane and sevoflurane in enzyme-induced hypoxic rats. World Journal of Gastroenterology 11 32 (2005) 5025-5028
27. Zhivotovsky B., Wade D., Gahm A., Orrenius S., and Nicotera P. Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS Letters 351 2 (1994) 150-154