Investigating idebenone and idebenone linoleate metabolism: In vitro pig ear and mouse melanocyte studies

Journal of Cosmetic Dermatology

Volumn 8, Issue 1, 2009, Pages 63-73

  Wempe, Michael F ^a,b   Lightner, Janet W ^a   Zoeller, Elizabeth L ^a   Rice, Peter J ^a,c  

^a EAST TENNESSEE STATE UNIVERSITY   (United States)

^b EASTMAN CHEMICAL COMPANY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Idebenone; Idebenone linoleate; Liquid chromatography mass spectrometry mass spectrometry; Melanocytes; Pig ear diffusion studies

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DERMATOLOGICAL AGENT; IDEBENONE; IDEBENONE ACID; IDEBENONE ALDEHYDE; IDEBENONE LINOLEATE; IDEBENONE SULFONATE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; LINOLEIC ACID; UBIQUINONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG DETERMINATION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG OXIDATION; DRUG PENETRATION; DRUG RESPONSE; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; EAR; EXPERIMENTAL PIG; MELANOCYTE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN PROTECTION; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG EFFECT; EXTERNAL EAR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; SENSITIVITY AND SPECIFICITY; SKIN ABSORPTION;

ANIMALS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EAR, EXTERNAL; IMMUNOHISTOCHEMISTRY; LINOLEIC ACID; MASS SPECTROMETRY; MELANOCYTES; MICE; SENSITIVITY AND SPECIFICITY; SKIN ABSORPTION; UBIQUINONE;

EID: 67049164173     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2009.00426.x     Document Type: Article

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