VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding

Thrombosis and Haemostasis

Volumn 101, Issue 6, 2009, Pages 1044-1050

  Spohn, Gabriele ^a,b,c,d   Kleinridders, Andre ^b,c   Wunderlich, F Thomas ^b,c   Watzka, Matthias ^a   Zaucke, Frank ^b   Blumbach, Katrin ^b   Geisen, Christof ^d   Seifried, Erhard ^d   Müller, Clemens ^e   Paulsson, Mats ^b   Brüning, Jens C ^b,c   Oldenburg, Johannes ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^d University of Ulm   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Bleeding phenotype; Bone phenotype; Knockout mouse; Vitamin K; VKORC1

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; MEMBRANE ENZYME; MENADIONE EPOXIDE; MESSENGER RNA; PROTHROMBIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE COMPLEX COMPONENT 1; VITAMIN K GROUP; BLOOD CLOTTING FACTOR; CARBON DIOXIDE; CARBOXYL RADICAL; MIXED FUNCTION OXIDASE; VITAMIN K EPOXIDE REDUCTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD CLOTTING; BONE MINERALIZATION; BRAIN HEMORRHAGE; CARBOXYLATION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME DEFICIENCY; KNOCKOUT MOUSE; LETHALITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VITAMIN K DEFICIENCY; VITAMIN K METABOLISM; ANIMAL; BLOOD; BONE; C57BL MOUSE; CELL CULTURE; CHEMISTRY; EMBRYONIC STEM CELL; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; LIMB; METABOLISM; NEWBORN; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; BLOOD COAGULATION FACTORS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CARBON DIOXIDE; CELLS, CULTURED; CEREBRAL HEMORRHAGE; EMBRYONIC STEM CELLS; EXTREMITIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIXED FUNCTION OXYGENASES; VITAMIN K; VITAMIN K EPOXIDE REDUCTASES;

EID: 67049155339     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH09-03-0204     Document Type: Article

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