Severe cervical dysplasia and nasal cartilage calcification following prenatal warfarin exposure

American Journal of Medical Genetics

Volumn 71, Issue 4, 1997, Pages 391-396

  Howe, A M ^a   Lipson, A H ^b   De Silva, M ^b   Ouvrier, R ^b   Webster, W S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Binder syndrome; Chondrodysplasia punctata; Ectopic calcification; Stippling; Vitamin K deficiency; Warfarin embryopathy

Indexed keywords

VITAMIN K GROUP; WARFARIN;

ARTICLE; CALCIFICATION; CASE REPORT; CERVICAL SPINE; DISEASE SEVERITY; HUMAN; HYPOTHESIS; INFANT; NOSE CARTILAGE; PRENATAL DIAGNOSIS; PRENATAL EXPOSURE; PRIORITY JOURNAL; UTERINE CERVIX DYSPLASIA;

ADOLESCENT; ANTITHROMBIN III DEFICIENCY; CALCINOSIS; CERVICAL VERTEBRAE; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; NASAL SEPTUM; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SPINAL CORD DISEASES; WARFARIN;

ANIMALIA;

EID: 0030866917     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19970905)71:4<391::AID-AJMG4>3.0.CO;2-X     Document Type: Article

References (30)

1. Abbott A, Sibert JR, Weaver JB (1977): Chondrodysplasia punctata and maternal warfarin treatment. Br Med J 1:1639-1640.
2. Baillie M, Allen D, Elkington AR (1980): The congenital warfarin syndrome: A case report. Br J Ophthalmol 64:633-635.
3. Becker MH, Genieser NB, Finegold M, Miranda D, Spackman T (1975): Chondrodysplasia punctata: Is maternal warfarin therapy a factor? Am J Dis Child 129:356-359.
4. DiSaia PJ (1966): Pregnancy and delivery of a patient with a Starr-Edwards mitral valve prosthesis: Report of a case. Obstet Gynecol 28: 469-472.
5. Gooch WM, McLendon RE, Parvey LS, Wilroy RS (1978): Warfarin embryopathy: Longitudinal and postmortem examination. Clin Res 26:74A.
6. Hall JG, Pauli RM, Wilson KM (1980): Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med 68:122-140.
7. Harrod MJE, Sherrod PS (1981): Warfarin embryopathy in siblings. Obstet Gynecol 57:673-676.
8. Holmberg L, Henriksson P, Ekelund H, Astedt B (1974): Coagulation in the human fetus. J Pediatr 85:860-864.
9. Horswell BB, Holmes AD, Levant BA, Barnett JS (1988): Cephalometric and anthropomorphic observations of Binder's syndrome: A study of 19 patients. Plastic Reconstr Surg 81:325-335.
10. Hosenfeld D, Wiedemann H-R (1989): Chondrodysplasia punctata in an adult recognised as vitamin K antagonist embryopathy. Clin Genet 35:376-381.
11. Howe AM, Webster WS (1992): The warfarin embryopathy: A rat model showing maxillonasal hypoplasia and other skeletal disturbances. Teratology 46:379-390.
12. Howe AM, Webster WS (1994): Vitamin K: Its essential role in craniofacial development. Aust Dental J 39:88-92.
13. Howe AM, Webster WS, Lipson AH, Halliday JL, Sheffield LJ ( 1992): Binder's syndrome due to prenatal vitamin K deficiency: A theory of pathogenesis. Aust Dental J 37:453-460.
14. Howe AM, Lipson AH, Sheffield LJ, Haan EA, Halliday JL, Jenson F, David DJ, Webster WS (1995): Prenatal exposure to phenytoin, facial development and a possible role for vitamin K. Am J Med Genet 58: 238-244.
15. Iturbe-Alessio I, Fonseca MC, Mutchinik O, Santos MA, Zajarias A, Salazar E (1986): Risks of anticoagulant therapy in pregnant women with artificial heart valves. N Engl J Med 315:1390-1393.
16. Olow-Nordenram M (1987): Maxillonasal dysplasia (Binder's syndrome): A study of craniofacial morphology, associated malformations and family relations. Swed Dent J Suppl 47:1-32.
17. Otawara Y, Price PA (1986): Developmental appearance of matrix gla protein during calcification in the rat. J Biol Chem 261:10828-10832.
18. Pauli RM, Madden JD, Kranzler KJ, Culpepper W, Port R (1976): Warfarin therapy initiated during pregnancy and phenotypic chondrodysplasia punctata. J Pediatr 88:506-508.
19. Pauli RM, Lian JB, Mosher DF, Suttie JW (1987): Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: Clues to the mechanism of teratogenicity of coumarin derivatives. Am J Hum Genet 41:566-583.
20. Poznanski AK (1994): Punctate epiphyses: A radiological sign not a disease. Pediatr Radiol 24:418-424.
21. Price PA, Lothringer JW, Baukol SA, Reddi AH (1981): Developmental appearance of the vitamin K dependent protein of bone during calcification: Analysis of mineralizing tissues in the human, calf and rat. J Biol Chem 256:3781-3784.
22. Price PA, Williamson MK, Haba T, Dell RB, Jee WSS (1982): Excessive mineralization with growth plate closure in rats on chronic warfarin treatment. Proc Natl Acad Sci USA 79:7734-7738.
23. Resche F, Tessier P, Delaire J, Tulasne JF (1980): Craniospinal and cervicospinal malformations associated with maxillonasal dysostosis (Binder syndrome) Head Neck Surg 3:123-131.
24. Rifkin MD, Pritzker HA (1984): Tracheobronchial cartilage calcification in children: Case reports and review of the literature. Br J Radiol 57:293-296.
25. Robinson MJ, Pash J, Grimwade J, Campbell J (1978): Fetal warfarin syndrome. Med J Aust i:157.
26. Scott JH (1953): The cartilage of the nasal septum: A contribution to the study of facial growth. Br Dent J 95:37-43.
27. Shaul WL, Hall JG (1977) Multiple congenital anomalies associated with oral anticoagulants. Am J Obstet Gynecol 127:191-198.
28. Shaul WL, Emery H, Hall JG (1975): Chondrodysplasia punctata and maternal warfarin use during pregnancy. Am J Dis Child 129:360-362.
29. Suttie JW (1991): Vitamin K In: Machlin LJ (ed): "Handbook of Vitamins, 2nd Edition Nutritional, Biochemical and Clinical Aspects." New York: Marcel Dekker, pp 145-194.
30. Taybi H, Capitanio MA (1990): Tracheobronchial calcification: An observation in three children after mitral valve replacement and warfarin sodium therapy. Radiology 176:728-730.