Molecular basis of substrate selection by the N-end rule adaptor protein ClpS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 22, 2009, Pages 8888-8893

  Román Hernández, Giselle ^a   Grant, Robert A ^a   Sauer, Robert T ^a   Baker, Tania A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

AAA+ ATPase adaptor; clpAP protease; Degradation tag; Degron

Indexed keywords

ADAPTOR PROTEIN; AMINO ACID DERIVATIVE; CLPS PROTEIN; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; WILD TYPE;

CARRIER PROTEINS; CAULOBACTER CRESCENTUS; CRYSTALLOGRAPHY, X-RAY; ENDOPEPTIDASE CLP; METHIONINE; PEPTIDES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 67049154051     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903614106     Document Type: Article

References (30)

1. Gottesman S (2003) Proteolysis in bacterial regulatory circuits. Annu Rev Cell Dev Biol 19:565-587. (Pubitemid 37487361)
2. Sauer RT, et al. (2004) Sculpting the proteome with AAA+ proteases and disassembly machines. Cell 119:9-18. (Pubitemid 39349316)
3. Hanson PI, Whiteheart SW (2005) AAA+ proteins: Have engine, will work. Nat Rev Moll Cell Biol 6:519-529. (Pubitemid 40943043)
4. Mogk A, Schmidt R, Bukau B (2007) The N-end rule pathway for regulated proteolysis: Prokaryotic and eukaryotic strategies. Trends Cell Biol 17:165-172. (Pubitemid 46507804)
5. Baker TA, Sauer RT (2006) ATP-dependent proteases of bacteria: Recognition logic and operating principles. Trends Biochem Sci 31:647-653. (Pubitemid 44791948)
6. Dougan DA, Reid BG, Horwich AL, Bukau B (2002) ClpS, a susbstrate modulator of the ClpAP machine. Mol Cell 9:673-683. (Pubitemid 34273796)
7. Guo F, Maurizi MR, Esser L, Xia D (2002) Crystal structure of ClpA, an Hsp100 chaperone and regulator of ClpAP protease. J Biol Chem 277:46743-46752. (Pubitemid 35417677)
8. Zeth K, et al. (2002) Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA. Nat Struct Biol 9:906-911. (Pubitemid 35417058)
9. Erbse A, et al. (2006) ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature 439:753-756. (Pubitemid 43237625)
10. Wang KH, Sauer RT, Baker TA (2007) ClpS modulates but is not essential for bacterial N-end rule degradation. Genes Dev 21:403-408. (Pubitemid 46310176)
11. Hou JY, Sauer RT, Baker TA (2008) Distinct structural elements of the adaptor ClpS are required for regulating degradation by ClpAP. Nat Struct Mol Biol 15:288-294. (Pubitemid 351654046)
12. Varshavsky A (1996) The N-end rule: Functions, mysteries, uses. Proc Natl Acad Sci USA 93:12142-12149.
13. Tobias JW, Shrader TE, Rocap G, Varshavsky A (1991) The N-end rule in bacteria. Science 254:1374-1377. (Pubitemid 21917472)
14. Barter B, Wunning I, Varshavsky A (1990) The recognition component of the N-end rule pathway. EMBO J 9:3179-3189. (Pubitemid 20282530)
15. Tasaki T, Tae Kwon Y (2007) The mammalian N-end rule pathway: New insights into its components and physiological roles. Trends Biochem Sci 32:520-528. (Pubitemid 350008070)
16. Lupas AN, Koretke KK (2003) Bioinformatic analysis of ClpS, a protein module involved in prokaryotic and eukaryotic protein degradation. J Struct Biol 141:77-83. (Pubitemid 36269108)
17. Wang KH, Roman-Hernandez G, Grant RA, Sauer RT, Baker TA (2008) The molecular basis of N-end rule recognition. Mol Cell 32:1-9.
18. Wang KH, Oakes E, Sauer RT, Baker TA (2008) Tuning the strength of a bacterial N-end rule signal. J Biol Chem 283:24600-24607.
19. Frottin F, et al. (2006) The proteomics of N-terminal methionine cleavage. Mol Cell Proteomics 5:2336-2349. (Pubitemid 46040638)
20. Link AJ, Robison K, Church GM (1997) Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K12. Electrophoresis 18:1259-1313. (Pubitemid 27371433)
21. Lovell SC, Word JM, Richardson JS, Richardson DC (2000) The penultimate rotamer library. Proteins Struct Funct Genet 40:389-408. (Pubitemid 30624447)
22. Liao YD, Jeng JC, Wang SC, Chang ST (2004) Removal of N-terminal methionine from recombinant proteins by engineered E. coli methionine aminopeptidase. Protein Sci 13:1802-1810. (Pubitemid 38822119)
23. Bradshaw R, Brickey W, Walker K (1998) N-terminal processing: The methionine aminopeptidase and N-acetyl transferase families. Trends Biochem Sci 23:263-267. (Pubitemid 28343371)
24. Lipscomb LA, et al. (1998) Context-dependent protein stabilization by methionine-toleucine substitution shown in T4 lysozyme. Protein Sci 7:765-773. (Pubitemid 28130899)
25. Maurizi MR, Clark WP, Kim SH, Gottesman S (1990) Clp P represents a unique family of serine proteases. J Biol Chem 265:12546-12552. (Pubitemid 20226924)
26. Kim YI, Burton RE, Burton BM, Sauer RT, Baker TA (2000) Dynamics of substrate denaturation and translocation by the ClpXP degradation machine. Mol Cell 5:639-648.
27. Otwinowski Z, Minor W (1997) Processing of X-ray diffraction data collected inoscillation mode. Methods Enzymol 276:307-326. (Pubitemid 27085611)
28. Storoni LC, McCoy AJ, Read RJ (2004) Likelihood-enhanced fast rotation functions. Acta Crystallogr D 60:432-438. (Pubitemid 41087570)
29. Emsley P, Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D 60:2126-2132. (Pubitemid 41742764)
30. Adams PD, et al. (2002) PHENIX: Building new software for automated crystallographic structure determination. Acta Crystallogr D 58:1948-1954. (Pubitemid 35337293)