On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Journal of Pharmaceutical Sciences

Volumn 98, Issue 6, 2009, Pages 1922-1927

  Berezhkovskiy, Leonid M ^a   Khojasteh, S Cyrus ^a   Halladay, Jason S ^a   Hop, Cornelis E C A ^a  

^a GENENTECH INC   (United States)

Author keywords

Hepatic clearance; Intrinsic clearance; Metabolic stability; Microsomal binding; Pharmacokinetics; Protein binding; Well stirred model

Indexed keywords

PLASMA PROTEIN;

ACCURACY; CALCULATION; CONCENTRATION (PARAMETERS); DILUTION; DRUG METABOLISM; DRUG PROTEIN BINDING; HALF LIFE TIME; IN VITRO STUDY; IN VIVO STUDY; LIVER CLEARANCE; LIVER MICROSOME; MEASUREMENT; NOTE; PLASMA; PLASMA PROTEIN BINDING; PREDICTION;

EID: 67049134867     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21582     Document Type: Note

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