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Volumn 47, Issue 9, 2009, Pages 2236-2245

Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food

Author keywords

Contaminants; Food safety; Risk ranking; Threshold of regulation; Threshold of toxicological concern, TTC

Indexed keywords

CARCINOGEN; DOMESTIC CHEMICAL; ORGANOPHOSPHATE;

EID: 67049126669     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.06.018     Document Type: Article
Times cited : (35)

References (41)
  • 1
    • 0000973407 scopus 로고
    • Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the U.S. NTP
    • Ashby J., and Tennant R.W. Definitive relationships among chemical structure, carcinogenicity, and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat. Res. 257 (1991) 229-306
    • (1991) Mutat. Res. , vol.257 , pp. 229-306
    • Ashby, J.1    Tennant, R.W.2
  • 3
    • 49849084348 scopus 로고    scopus 로고
    • Structure alerts for carcinogenicity, and the Salmonella assay system: a novel insight through the chemical relational databases technology
    • Benigni R., and Bossa C. Structure alerts for carcinogenicity, and the Salmonella assay system: a novel insight through the chemical relational databases technology. Mutat. Res. 659 (2008) 248-261
    • (2008) Mutat. Res. , vol.659 , pp. 248-261
    • Benigni, R.1    Bossa, C.2
  • 5
    • 2942516278 scopus 로고    scopus 로고
    • Risk assessment of peak exposure to genotoxic carcinogens: a pragmatic approach
    • Bos P.M.J., Baars B.J., and van Raaij M.T.M. Risk assessment of peak exposure to genotoxic carcinogens: a pragmatic approach. Toxicol. Lett. 151 1 (2004) 43-50
    • (2004) Toxicol. Lett. , vol.151 , Issue.1 , pp. 43-50
    • Bos, P.M.J.1    Baars, B.J.2    van Raaij, M.T.M.3
  • 6
    • 68049144988 scopus 로고    scopus 로고
    • CFR (21 Code of Federal Regulations, Part 110). 2003. Current Good Manufacturing Practice in Manufacturing, Processing, Packing, or Holding Human Food. .
    • CFR (21 Code of Federal Regulations, Part 110). 2003. Current Good Manufacturing Practice in Manufacturing, Processing, Packing, or Holding Human Food. .
  • 8
    • 0018079206 scopus 로고
    • Estimation of a toxic hazard-a decision tree approach. Review
    • Cramer G.M., Ford R.A., and Hall R.L. Estimation of a toxic hazard-a decision tree approach. Review. Food Cosmet. Toxicol. 16 (1978) 255-276
    • (1978) Food Cosmet. Toxicol. , vol.16 , pp. 255-276
    • Cramer, G.M.1    Ford, R.A.2    Hall, R.L.3
  • 9
    • 68049129898 scopus 로고    scopus 로고
    • ECHA, 2008. European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Chapter R.8: Characterisation of dose [concentration]-response for human health. May 2008.
    • ECHA, 2008. European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Chapter R.8: Characterisation of dose [concentration]-response for human health. May 2008.
  • 10
    • 68049123454 scopus 로고    scopus 로고
    • EFSA, 2004. European Food Safety Authority. Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. Opinion on Flavouring Group FGE.03 Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes, and an orthoester of formic acid, from chemical groups 1 and 2. Opinion expressed on 7 October 2004. .
    • EFSA, 2004. European Food Safety Authority. Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. Opinion on Flavouring Group FGE.03 Acetals of branched- and straight-chain aliphatic saturated primary alcohols and branched- and straight-chain saturated aldehydes, and an orthoester of formic acid, from chemical groups 1 and 2. Opinion expressed on 7 October 2004. .
  • 11
    • 68049147602 scopus 로고    scopus 로고
    • EFSA, 2005. European Food Safety Authority. Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004-020). Opinion adopted on 18 October 2005).
    • EFSA, 2005. European Food Safety Authority. Opinion of the Scientific Committee on a request from EFSA related to a harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. (Request No EFSA-Q-2004-020). Opinion adopted on 18 October 2005).
  • 12
    • 68049139599 scopus 로고    scopus 로고
    • EMEA, 2006. European Medicines Evaluation Agency. Committee for Medicinal Products for Human Use (CHMP). Guideline on the limits of genotoxic impurities. CPMP/SWP/5199/02. London, 28 June 2006. EMEA/CHMP/QWP/251344/2006. .
    • EMEA, 2006. European Medicines Evaluation Agency. Committee for Medicinal Products for Human Use (CHMP). Guideline on the limits of genotoxic impurities. CPMP/SWP/5199/02. London, 28 June 2006. EMEA/CHMP/QWP/251344/2006. .
  • 13
    • 68049128149 scopus 로고    scopus 로고
    • EMEA (European Medicines Evaluation Agency). 2008. Committee for Medicinal Products for Human Use (CHMP). Questions & Answers on the CHMP Guideline on the limits of Genotoxic Impurities. Rev 1. London, 26 June 2008. Doc.Ref. EMEA/CHMP/SWP/431994/2007.
    • EMEA (European Medicines Evaluation Agency). 2008. Committee for Medicinal Products for Human Use (CHMP). Questions & Answers on the CHMP Guideline on the limits of Genotoxic Impurities. Rev 1. London, 26 June 2008. Doc.Ref. EMEA/CHMP/SWP/431994/2007.
  • 14
    • 68049148680 scopus 로고    scopus 로고
    • EPA (US Environmental Protection Agency), 2005. Guidelines for Carcinogen Risk Assessment. Washington, DC. EPA/630/P-03/001B.
    • EPA (US Environmental Protection Agency), 2005. Guidelines for Carcinogen Risk Assessment. Washington, DC. EPA/630/P-03/001B.
  • 15
    • 68049120498 scopus 로고    scopus 로고
    • FDA, 1993. Food and Drug Administration. Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food. Redbook, US Food and Drug Administration, Bureau of Foods, Washington, DC.
    • FDA, 1993. Food and Drug Administration. Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food. Redbook, US Food and Drug Administration, Bureau of Foods, Washington, DC.
  • 16
    • 0000493162 scopus 로고
    • Food and Drug Administration. Food additives: Threshold of regulation of substances used in food-contact articles: Final rule
    • FDA
    • FDA, 1995. Food and Drug Administration. Food additives: Threshold of regulation of substances used in food-contact articles: Final rule. Federal Register 60, 36582-36596.
    • (1995) Federal Register , vol.60 , pp. 36582-36596
  • 17
    • 68049145925 scopus 로고    scopus 로고
    • Committee on Food Chemicals Codex
    • FCC Food Chemicals Codex, sixth ed, February
    • FCC (Food Chemicals Codex), 2008. Committee on Food Chemicals Codex, sixth ed. United States Pharmacopeia (February).
    • (2008) United States Pharmacopeia
  • 18
    • 0014119349 scopus 로고
    • Scientific evidence and common sense as a basis for food-packaging regulations
    • Frawley J.P. Scientific evidence and common sense as a basis for food-packaging regulations. Food Chem. Toxicol. 5 (1967) 293-308
    • (1967) Food Chem. Toxicol. , vol.5 , pp. 293-308
    • Frawley, J.P.1
  • 19
    • 0034648274 scopus 로고    scopus 로고
    • The use of Haber's Law in standard setting and risk assessment
    • Gaylor D.W. The use of Haber's Law in standard setting and risk assessment. Toxicology 149 1 (2000) 17-19
    • (2000) Toxicology , vol.149 , Issue.1 , pp. 17-19
    • Gaylor, D.W.1
  • 21
    • 0029416905 scopus 로고
    • Sixth plot of the carcinogenic potency database: results of animal bioassays published in the general literature 1989-1990 and by the US NTP 1990-1993
    • Gold L.S., Manley N.B., Slone T.H., Garfinkel G.B., Ames B.N., Rohrbach L., Stern B.R., and Chow K. Sixth plot of the carcinogenic potency database: results of animal bioassays published in the general literature 1989-1990 and by the US NTP 1990-1993. Environ. Health Perspect. 103 Suppl. 8 (1995) 3-122
    • (1995) Environ. Health Perspect. , vol.103 , Issue.SUPPL. 8 , pp. 3-122
    • Gold, L.S.1    Manley, N.B.2    Slone, T.H.3    Garfinkel, G.B.4    Ames, B.N.5    Rohrbach, L.6    Stern, B.R.7    Chow, K.8
  • 22
    • 68049126454 scopus 로고    scopus 로고
    • HACCP, 1997. Joint FAO/WHO Food Standards Programme, Codex Alimentarius Commission, Food Hygiene Basic Texts, second ed., Hazard Analysis and Critical Control Point (HACCP) System and Guidelines for its Application, pp. 33-44 (rev. 3).
    • HACCP, 1997. Joint FAO/WHO Food Standards Programme, Codex Alimentarius Commission, Food Hygiene Basic Texts, second ed., Hazard Analysis and Critical Control Point (HACCP) System and Guidelines for its Application, pp. 33-44 (rev. 3).
  • 23
    • 0033752638 scopus 로고    scopus 로고
    • Reevaluating cancer risk estimates for short-term exposure scenarios
    • Halmes N.C., Roberts S.M., Tolson J.K., and Portier C.J. Reevaluating cancer risk estimates for short-term exposure scenarios. Toxicol. Sci. 58 (2000) 32-42
    • (2000) Toxicol. Sci. , vol.58 , pp. 32-42
    • Halmes, N.C.1    Roberts, S.M.2    Tolson, J.K.3    Portier, C.J.4
  • 24
    • 68049145924 scopus 로고    scopus 로고
    • A procedure for the safety evaluation of flavouring agents
    • JECFA, Annex 5. World Health Organization, Geneva
    • JECFA, 1996. A procedure for the safety evaluation of flavouring agents. WHO Food Additive Series 35. Annex 5. World Health Organization, Geneva.
    • (1996) WHO Food Additive Series , vol.35
  • 25
    • 0003391968 scopus 로고    scopus 로고
    • Safety evaluation of certain food additives and contaminants
    • JECFA, WHO Food Additive Series 40. World Health Organization, Geneva
    • JECFA, 1997. Safety evaluation of certain food additives and contaminants. Forty-ninth Report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Food Additive Series 40. World Health Organization, Geneva.
    • (1997) Forty-ninth Report of the Joint FAO/WHO Expert Committee on Food Additives
  • 26
    • 0034010667 scopus 로고    scopus 로고
    • Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing
    • Kroes R., Galli C.L., Munro I., Schilter B., Tran L.A., Walker R., and Würtzen G. Threshold of toxicological concern for chemical substances present in the diet: a practical tool for assessing the need for toxicity testing. Food Chem. Toxicol. 38 (2000) 255-312
    • (2000) Food Chem. Toxicol. , vol.38 , pp. 255-312
    • Kroes, R.1    Galli, C.L.2    Munro, I.3    Schilter, B.4    Tran, L.A.5    Walker, R.6    Würtzen, G.7
  • 28
    • 26444572796 scopus 로고    scopus 로고
    • The threshold of toxicological concern concept in risk assessment
    • Kroes R., Kleiner J., and Renwick A. The threshold of toxicological concern concept in risk assessment. Toxicol. Sci. 86 (2005) 226-230
    • (2005) Toxicol. Sci. , vol.86 , pp. 226-230
    • Kroes, R.1    Kleiner, J.2    Renwick, A.3
  • 30
    • 33645840463 scopus 로고    scopus 로고
    • A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity
    • Muller L., Mauthe R.J., Riley C.M., et al. A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity. Regul. Toxicol. Pharmacol. 44 (2006) 198-211
    • (2006) Regul. Toxicol. Pharmacol. , vol.44 , pp. 198-211
    • Muller, L.1    Mauthe, R.J.2    Riley, C.M.3
  • 31
    • 0025185557 scopus 로고
    • Safety assessment procedures for indirect food additives: an overview. Report of a workshop
    • Munro I.C. Safety assessment procedures for indirect food additives: an overview. Report of a workshop. Regul. Toxicol. Pharmacol. 12 (1990) 2-12
    • (1990) Regul. Toxicol. Pharmacol. , vol.12 , pp. 2-12
    • Munro, I.C.1
  • 32
    • 68049123452 scopus 로고    scopus 로고
    • A procedure for the safety evaluation of flavouring substances. Toxicological evaluation of certain food additives and contaminants. Prepared for the Joint FAO/WHO Expert Committee on Food Additives
    • Number 35, Annex 5
    • Munro, I.C., 1996. A procedure for the safety evaluation of flavouring substances. Toxicological evaluation of certain food additives and contaminants. Prepared for the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, Number 35, Annex 5.
    • (1996) WHO Technical Report Series
    • Munro, I.C.1
  • 33
    • 48649102067 scopus 로고    scopus 로고
    • The threshold of toxicological concern (TTC) in risk assessment
    • Munro I.C., Renwick A.G., and Danielwska-Nikiel B. The threshold of toxicological concern (TTC) in risk assessment. Toxicol. Lett. 180 (2008) 151-156
    • (2008) Toxicol. Lett. , vol.180 , pp. 151-156
    • Munro, I.C.1    Renwick, A.G.2    Danielwska-Nikiel, B.3
  • 34
    • 0030250802 scopus 로고    scopus 로고
    • Correlation of structural class with no-observed effect levels: a proposal for establishing a threshold of concern
    • Munro I.C., Ford R.A., Kennepohl E., and Sprenger J.G. Correlation of structural class with no-observed effect levels: a proposal for establishing a threshold of concern. Food Chem. Toxicol. 34 (1996) 829-867
    • (1996) Food Chem. Toxicol. , vol.34 , pp. 829-867
    • Munro, I.C.1    Ford, R.A.2    Kennepohl, E.3    Sprenger, J.G.4
  • 35
    • 0027083378 scopus 로고
    • Cancer risk assessment with intermittent exposure
    • Murdoch D.J., Krewski D., and Wargo J. Cancer risk assessment with intermittent exposure. Risk Anal. 12 4 (1992) 569-577
    • (1992) Risk Anal. , vol.12 , Issue.4 , pp. 569-577
    • Murdoch, D.J.1    Krewski, D.2    Wargo, J.3
  • 36
    • 33747345006 scopus 로고    scopus 로고
    • Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal
    • O'Brien J., Renwick A.G., Constable A., et al. Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal. Food Chem. Toxicol. 44 10 (2006) 1613-1635
    • (2006) Food Chem. Toxicol. , vol.44 , Issue.10 , pp. 1613-1635
    • O'Brien, J.1    Renwick, A.G.2    Constable, A.3
  • 38
    • 1842716625 scopus 로고    scopus 로고
    • Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents
    • Renwick A.G. Toxicology databases and the concept of thresholds of toxicological concern as used by the JECFA for the safety evaluation of flavouring agents. Toxicol. Lett. 149 (2004) 223-234
    • (2004) Toxicol. Lett. , vol.149 , pp. 223-234
    • Renwick, A.G.1
  • 39
    • 85130300802 scopus 로고
    • De Minimis and the threshold of regulation
    • Felix C.W. (Ed), Lewis Publishers Inc., Chelsea, MI
    • Rulis A.M. De Minimis and the threshold of regulation. In: Felix C.W. (Ed). Food Protection Technology (1986), Lewis Publishers Inc., Chelsea, MI 29-37
    • (1986) Food Protection Technology , pp. 29-37
    • Rulis, A.M.1
  • 40
    • 0002541461 scopus 로고
    • Threshold of regulation: Options for handling minimal risk situations
    • Finley, J.W, Robinson, S.F, Armstrong, D.J, Eds
    • Rulis, A., 1992. Threshold of regulation: options for handling minimal risk situations. In: Finley, J.W., Robinson, S.F., Armstrong, D.J. (Eds.), Food Safety Assessment. American Chemical Society Symposium Series, vol. 484, pp. 132-139.
    • (1992) Food Safety Assessment. American Chemical Society Symposium Series , vol.484 , pp. 132-139
    • Rulis, A.1


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