Evaluation of isoflavone rich soy protein supplementation for postmenopausal therapy

Pakistan Journal of Nutrition

Volumn 8, Issue 7, 2009, Pages 1009-1017

  Radhakrishnan, Gita ^a   Rashmi, ^a   Agarwal, Neera ^a   Vaid, Neelam B ^a  

^a UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

Author keywords

Alternative therapy; Climacteric; Hot flashes; Isoflavones; Post menopausal; Soy proteins

Indexed keywords

CASEIN; CHOLESTEROL; ESTRADIOL; FOLLITROPIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOFLAVONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SOYBEAN PROTEIN;

ABDOMINAL DISTENSION; ADULT; ARTHRALGIA; ARTICLE; BLOATING; BLOOD PRESSURE; BONE DENSITY; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ENDOMETRIUM; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HOT FLUSH; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSAL SYNDROME; NAUSEA AND VOMITING; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SKIN BRUISING; TREATMENT RESPONSE; VAGINA CYTOLOGY; WEAKNESS;

EID: 66949173388     PISSN: 16805194     EISSN: None     Source Type: Journal    
DOI: 10.3923/pjn.2009.1009.1017     Document Type: Article

References (39)

1. Albertazzi, P., F. Pansini, G. Bonaccorsi, L. Zanothi, E. Forini and D. De Aloysio, 1998. The effects of dietary soy supplementation on hot flashes. Obstet. Gynecol., 91: 6-10.
2. Allen, J.K., D.M. Becker, P.O. Kwiterwich, K.A. Lindenstruth and C. Curtis, 2007. Effect of soy protein containing isoflavones on lipoproteins in postmenopausal women. Menpause, 14: 106-114.
3. American College of Obstetricians and Gynecologists, 2002. Response to Women's health Initiative Study Results by The ACOG.
4. Anderson, J.W., B.M. Johnstone and M.E. Cook-Newell, 1995. Meta-analysis of the effects of soy protein intake on serum lipids. N. Eng. J. Med., 333: 276-282.
5. Baird, D.D., D.M. Umbach and L. Lansdell, 1995. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J. Clin. Endocrinol. Metab., 80: 685-690.
6. Ballntyne, C.M., 1998. Low density lipoproteins and risk for coronary artery disease. Am. J. Cardiol., 82: 3Q-12Q.
7. Boulet, M.J., B.J. Oddens, P. Lehert and H.M. Vener, 1994. A. Visser, climacteric and menopause in seven Southeast Asian countries. Maturitas, 19: 157-176.
8. Brzezinski, A., H. Aldercrautz and R. Shaoul, 1997. Short term effects of phytoestrogen rich diet on postmenopausal women. Menopause, 4: 89-94.
9. Cullen, P., 2000. Evidence that triglycerides are an independent coronary heart disease risk factor. Am. J. Cardiol., 86: 943-949.
10. Dalais, F.S., P.R. Ebeling, D. Kotsopoulos, B.P. McGrath and H.J. Teede, 2003. The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women. Clin. Endocrinol., 58: 704-709.
11. Faure, E.D., P. Chantre and P. Mares, 2002. Effects of a randomized soy extract on hot flushes: A multicentric, double blind randomized, placebo controlled study. Menopause, 9: 329-334.
12. Food and Drug Administration, 1999. Food labeling: health claims: Soy protein and coronary heart disease. Fed. Regist., 64: 57700-57733.
13. Grady, D., D. Herrington, V. Bittner, R. Blumenthal, M. Davidson and M. Hlatky et al., 2002. For the HERS Research Group. Cardiovascular disease outcomes during 6.8 years of hormone therapy. Heart and Estrogen/ Progestin Replacement Study Follow up (HERS II). JAMA , 288: 49-57.
14. Hale, G.E., C.L. Hughes and J.M. Cline, 2002. Endometrial cancer: hormonal factors, the perimenopausal window of risk and isoflavones. J. Clin. Endocrinol. Metab., 87: 3-15.
15. Han, K.K., J.M. Soares and M.A. Haidar, 2002. Rodrigues de Lima G, Baracat EC. Benefits of soy isoflavones therapeutic regimen on menopausal symptoms. Obstet. Gynecol., 99: 389-394.
16. Huntleay, A.L. and E. Ernst, 2004. Soy for the treatment of perimenopausal symptoms-a systematic review. Maturitas, 47: 1-9.
17. Jaku, K., K. Umagaki, Y. Sato, Y. Taki, K. Endoh and S. Watanabe, 2007. Soy isoflavoens lowers serum total and LDL cholesterol in humans: a meta analysis of 11 randomized controlled trials. Am. J. Clin. Nutr., 85: 1148-1156.
18. Kam, I.W., C.E. Zdennehy and C. Tsourounis, 2002. Dietary supplement use among postmenopausal women attending a San Francisco health conference. Menopause, 9: 72-78.
19. Krebs, E.E., K.E. Ensrud, R. MacDonald and T.J. Wilt, 2004. Phytoestrogens for treatment of menopausal symptoms. A systematic review. Obstet. Gynecol., 104: 824-836.
20. Kupperman, H.S., H.G. Meyer, M.H.G. Blatt, H. Wiesbader and W. Filler, 1953. Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorrheal indices. J. Clin. Endocrinol., 13: 688-703.
21. Lewis, J.E., L.A. Nickell, L.U. Thompson, L.U. Szalai, J.P. Kiss and A.J.R. Hilditch, 2006. A randomized controlled trial of the effect of dietary soy and flaxseed muffins on the quality of life and hot flashes during menopause. Menopause, 13: 631-642.
22. Lipid Research Clinics Program, 1984. The lipid research clinic coronary artery prevention trial results: the relationship od reduction in incidence of coronary heart disease to cholesterol lowering. JAMA, 251: 365-374.
23. Manonai, J., S. Songchitsomboon, K. Chanda, J.H. Hong and S. Komindr, 2006. The effect of a soy rich diet on urogenital atrophy: A randomized, cross over trial. Maturits, 54: 135-14
24. Nahas, E.P., J.N. Neto, L. Luca, P. De, Trainan, A. Pontes and I. Dalben, 2004. Benefits of soy germ isoflavones in postmenopausal women with contraindications for conventional hormone replacement therapy. Maturitas, 48: 372-380.
25. Nelson, H.D., 2004. Commonly used types of postmenopausal estrogens for treatment of hot flashes: Scientific review. JAMA, 291: 1610-1620.
26. Potter, S.M., J.A. Baum, H. Tang, R.J. Stillman, N.F. Shay and J.W. Erdman, 1988. Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr., 68 (Suppl): 1375S-1379S.
27. Scambia, G., D. Mango, P.G. Signorita, R.A.. Angeli, C. Palena and D. Gallo et al., 2007. Clinical effects of a standardized soy extract in postmenopausal women: a pilot study. Menopause, 7: 105-111.
28. Teede, H.J., F.S. Dalais, D. Kotsopoulos, Liang Yu Lu, S. Davis and B.P. McGrath, 2001. Dietary soy has both beneficial and potentially adverse cardiovascular effects: A placebo controlled study in men and postmenopausal women. J. Clin. Endocrinol. Metab., 86: 3053-3060.
29. Tonstad, S., K. Smerud and L. Hoie, 2002. A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins and plasma total homocysteine in hypercholesterolemic subjects. Am. J. Clin. Nutr., 76: 78-84.
30. Unfer, V., M.L. Casini, L. Costabile, M. Mignosa, S. Gerli and G.C. Di Renzo, 2004. Endometrial effects of long term treatment with phytoestrogens: A randomized double blind placebo controlled study. Fertil Steril., 82: 145-148.
31. Vigna, G.B., F. Pansini, G. Bonaccorsi, P. Albertazzi, P. Donega and L. Zanotti et al., 2000. Plasma lipoproteins in soy treated postmenopausal women: A double blind, placebo controlled trial. Nutr. Metab. Cardiovasc. Dis., 10: 315-322.
32. Wangen, K.E., A.M. Duncan, B.E. Merz-Demlow, X. Xu, R. Marcus and W.R. Phipps, 2000. Effect of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women. J. Clin. Endocrinol. Metab., 85: 3043-3048.
33. Wangen, K.E., A.M. Duncan, X. Xu and M.S. Kurzer, 2001. Soyisoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J. Clin, Nutr., 73: 225-231.
34. Washburn, S., G.L. Burke, T. Morgan and M. Anthony, 1999. Effect of soy protein supplementation on serum lipoproteins, blood pressure and menopausal symptoms in perimenopaual women. Menopause, 6: 7-13.
35. Weggemans, R.M. and E.A. Trautwein, 2003. Relation between soy associated isoflavones and LDL and HDL cholesterol concentrations in humans: A meta analysis. Eur. J. Clin. Nutr., 57: 940-946.
36. Wilcox, G., M.L. Wahlqvist, H.G. Burger and G. Medley, 1990. Oestrogenic effects of plant foods in postmenopausal women. BMJ, 301: 905-906.
37. Wolff, L.P., M.R. Martins, A.J. Bedone and I.M. Monteiro, 2006. Endometrial evaluation in menopausal women after six months of isoflavones. Rev. Assoc. Med. Bras., 52: 419-423.
38. Writing Group for the Women's Health Initiative Investigations, 2002. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative Randomized Controlled Trial. JAMA, 288: 321-333.
39. Ye, Y.B., X.Y. Tang, M.A. Verbruggen and Y.X. Su, 2006. Soy isoflavones attenuate bone loss in early postmeno; ausal Chinese women; A single randomized, placebo controlled trial. Eur. J. Nutr., 45: 327-334.