In vivo measurements of tumor metabolism and growth after administration of nzastaurin using small animal FDG positron emission tomography

Journal of Oncology

Volumn , Issue , 2009, Pages

  Lahn, Michael ^b   Pollok, Karen E ^a   Enas, Nathan ^b   McNulty, Ann ^b   Graff, Jeremy ^b   Cai, Shanbao ^a   Hartwell, Jennifer R ^a   Ernstberger, Aaron ^a   Thornton, Donald ^b   Brail, Les ^b   Hutchins, Gary ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZASTAURIN; FLUORODEOXYGLUCOSE F 18; PROTEIN KINASE C BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER TRANSPLANTATION; CELL HETEROGENEITY; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; TUMOR CELL; TUMOR GROWTH; XENOGRAFT;

EID: 66949165546     PISSN: 16878450     EISSN: 16878469     Source Type: Journal    
DOI: 10.1155/2009/596560     Document Type: Article

References (27)

1. Gupta N., Price P. M., Aboagye E. O., PET for in vivo pharmacokinetic and pharmacodynamic measurements European Journal of Cancer 2002 38 16 2094 2107 (Pubitemid 35223247)
2. Vansteenkiste J. F., PET scan in the staging of non-small cell lung cancer Lung Cancer 2003 42 2, supplement 1 S27 S37
3. Juweid M. E., Wiseman G. A., Vose J. M., Response assessment of aggressive non-Hodgkins lymphoma by integrated International Workshop Criteria and fluorine-18-fluorodeoxyglucose positron emission tomography Journal of Clinical Oncology 2005 23 21 4652 4661 (Pubitemid 46224067)
4. Rajendran J. G., Mankoff D. A., OSullivan F., Hypoxia and glucose metabolism in malignant tumors: evaluation by [ 18 F ]fluoromisonidazole and [ 18 F ]fluorodeoxyglucose positron emission tomography imaging Clinical Cancer Research 2004 10 7 2245 2252 (Pubitemid 38445681)
5. Antoch G., Saoudi N., Kuehl H., Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET Journal of Clinical Oncology 2004 22 21 4357 4368 (Pubitemid 41185156)
6. Antoch G., Vogt F. M., Freudenberg L. S., Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology Journal of the American Medical Association 2003 290 24 3199 3206 (Pubitemid 38020681)
7. Sasaki R., Komaki R., Macapinlac H., [ 18 F ]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer Journal of Clinical Oncology 2005 23 6 1136 1143 (Pubitemid 46202269)
8. Blasberg R. G., Tjuvajev J. G., Molecular-genetic imaging: current and future perspectives The Journal of Clinical Investigation 2003 111 11 1620 1629 (Pubitemid 38057741)
9. Parker P. J., Murray-Rust J., PKC at a glance Journal of Cell Science 2004 117, part 2 131 132 (Pubitemid 38128893)
10. Shipp M. A., Ross K. N., Tamayo P., Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning Nature Medicine 2002 8 1 68 74 (Pubitemid 34101731)
11. Acevedo-Duncan M., Patel R., Whelan S., Bicaku E., Human glioma PKC- and PKC- II phosphorylate cyclin-dependent kinase activating kinase during the cell cycle Cell Proliferation 2002 35 1 23 36 (Pubitemid 34592059)
12. Graff J. R., McNulty A. M., Hanna K. R., The protein kinase C -selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts Cancer Research 2005 65 16 7462 7469 (Pubitemid 41161281)
13. Alcantara O., Obeid L., Hannun Y., Ponka P., Boldt D. H., Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC- and PKC- gene expression and role of the 5 ′ -flanking region of the PKC- gene in the response to ferric transferrin Blood 1994 84 10 3510 3517
14. Frese T., Rouze N. C., Bouman C. A., Sauer K., Hutchins G. D., Quantitative comparison of FBP, EM, and Bayesian reconstruction algorithms for the IndyPET scanner IEEE Transactions on Medical Imaging 2003 22 2 258 276
15. Rouze N. C., Hutchins G. D., Design and characterization of IndyPET-II: a high-resolution, high-sensitivity dedicated research scanner IEEE Transactions on Nuclear Science 2003 50 5, part 2 1491 1497
16. Hamacher K., Coenen H. H., Stocklin G., Efficient stereospecific synthesis of no-carrier-added 2-[ 18 F ]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution Journal of Nuclear Medicine 1986 27 2 235 238 (Pubitemid 17024868)
17. Tian M., Zhang H., Higuchi T., Oriuchi N., Inoue T., Endo K., Effect of mitomycin C and vinblastine on FDG uptake of human nonsmall-cell lung cancer xenografts in nude mice Cancer Biotherapy and Radiopharmaceuticals 2004 19 5 601 605 (Pubitemid 39546299)
18. Leyton J., Latigo J. R., Perumal M., Dhaliwal H., He Q., Aboagye E. O., Early detection of tumor response to chemotherapy by 3 ′ -deoxy- 3 ′ -[ 18 F ]fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo Cancer Research 2005 65 10 4202 4210 (Pubitemid 40775658)
19. Cullinane C., Dorow D. S., Kansara M., An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development Cancer Research 2005 65 21 9633 9636 (Pubitemid 41541437)
20. Seemann M. D., Human PET/CT scanners: feasibility for oncological in vivo imaging in mice European Journal of Medical Research 2004 9 10 468 472
21. Tatsumi M., Nakamoto Y., Traughber B., Marshall L. T., Geschwind J.-F., Wahl R. L., Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18]fluoro-2-deoxy-D-glucose Cancer Research 2003 63 19 6252 6257 (Pubitemid 37255171)
22. Gallo A., Ceolotto G., Pinton P., Metformin prevents glucose-induced protein kinase C- 2 activation in human umbilical vein endothelial cells through an antioxidant mechanism Diabetes 2005 54 4 1123 1131 (Pubitemid 40446327)
23. Ishizuka T., Kajita K., Natsume Y., Protein kinase C (PKC) modulates serine phosphorylation of insulin receptor substrate-1 (IRS-1)effect of overexpression of PKC on insulin signal transduction Endocrine Research 2004 30 2 287 299 (Pubitemid 39243128)
24. Kouroedov A., Eto M., Joch H., Volpe M., Lscher T. F., Cosentino F., Selective inhibition of protein kinase C 2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells Circulation 2004 110 1 91 96 (Pubitemid 38880139)
25. Yamamoto M., Patel N. A., Taggart J., Sridhar R., Cooper D. R., A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC- II International Journal of Cancer 1999 83 1 98 106 (Pubitemid 29409484)
26. Kelloff G. J., Hoffman J. M., Johnson B., Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development Clinical Cancer Research 2005 11 8 2785 2808 (Pubitemid 40525178)
27. Miller K. D., Miller M., Mehrotra S., A physiologic imaging pilot study of breast cancer treated with AZD2171 Clinical Cancer Research 2006 12 1 281 288 (Pubitemid 43166205)