A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-βII

International Journal of Cancer

Volumn 83, Issue 1, 1999, Pages 98-106

  Yamamoto, Mayumi ^a   Patel, Niketa A ^a   Taggart, Jennifer ^a   Sridhar, Rajagopalan ^c   Cooper, Denise R ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c HOWARD UNIVERSITY CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; ISOENZYME; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ARTICLE; BREAST CANCER; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME REPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIVISION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; GLUCOSE; HUMANS; ISOENZYMES; MANNITOL; PHTHALIMIDES; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0032856557     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990924)83:1<98::AID-IJC18>3.0.CO;2-V     Document Type: Article

References (27)

1. BARR, L.F., CAMPBELL, S.E. and BAYLIN, S.B., Protein kinase C-β2 inhibits cycling and decreases c-myc-induced apoptosis in small cell lung cancer cells. Cell Growth Differentiation, 8, 381-392 (1997).
2. BLOBE, G.C., SACHS, C.W., KHAN, W.A., FABBRO, D., STABEL, S., WETSEL, W.C., OBEID, L.M., FINE, R.L. and HANNUN, Y.A., Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKCα. J. biol. Chem., 268, 658-664 (1993).
3. BRADFORD, M.M., A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
4. BRADLEY, G., JURANKA, P.F. and LING, V., Mechanism of multidrug resistance. Biochem. biophys. Acta, 948, 87-128 (1988).
5. BUDWORTH, J., GANT, T.W. and GESCHER, A., Co-ordinate loss of protein kinase C and multidrug resistance gene expression in revenant MCF-7/Adr breast carcinoma cells. Brit. J. Cancer, 75, 1330-1335 (1997).
6. CHALFANT, C.E., MISCHAK, H., WATSON, J.E., WINKLER, B.C., GOODNIGHT, J., FARESE, R.V. and COOPER, D.R., Regulation of alternative splicing of protein kinase Cβ by insulin. J. biol. Chem., 270, 13326-13332 (1995).
7. CHALFANT, C.E., OHNO, S., KONNO, Y., FISHER, A.A., BISNAUTH, L.D., WATSON, J.E. and COOPER, D.R., A carboxy-terminal deletion mutant of protein kinase CβII inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells. Mol. Endocrinol., 10, 1273-1281 (1996).
8. COOPER, D.R., KHALAKDINA, A. and WATSON, J.E., Chronic effects of glucose on insulin signaling in A-10 vascular smooth muscle cells. Arch. Biochem. Biophys., 302, 490-498 (1993a).
9. COOPER, D.R., WATSON, J.E. and DAO, M.L., Decreased expression of protein kinase C α, β, and ∈ in soleus muscle of Zucker obese (fa/fa) rats. Endocrinology, 133, 2241-2247 (1993b).
10. DE VENTE, J.E., KUKOLY, C.A., BRYANT, W.O., POSEKANY, K.J., CHEN, J., FLETCHER, D.J., PARKER, P.J., PETTIT, G.J., LOZANO, G., COOK, P.P. and WAYS, D.K., Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd45 in initiating death. J. clin. Invest., 96, 1874-1886 (1995).
11. FINE, R.L., PATEL, J. and CHABNER, B.A., Phorbol esters induce multidrug resistance in human breast cancer cells. Proc. nat. Acad. Sci. (Wash.), 85, 582-586 (1988).
12. GABBAY, R.A., SICONOLFI-BAEZ, L. and LEBOVITZ, H.E., Calcium-dependent protein kinase activity is decreased in diabetic rat sciatic nerve. Endocrinology, 127, 1194-1198 (1990).
13. GUNDIMEDA, U., CHEN, Z.-H. and GOPALAKRISHNA, R., Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J. biol. Chem., 271, 13504-13514 (1996).
14. HAMADA, H. and TSURUO, T., Characterization of the ATPase activity of the Mr170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res., 48, 4926-4932 (1988).
15. ISSANDOU, M., BAYARD, F. and DARBON, J.-M., Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells. Cancer Res., 50, 5845-5850 (1990).
16. JOHANNES, F.-J., PRESTLE, J., EIS, S., OBERHAGEMANN, P. and PFIZENMAIER, K., PKCu is a novel, atypical member of the protein kinase C family. J. biol. Chem., 269, 6140-6148 (1994).
17. LAEMMLI, U.K., Clevage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227, 680-685 (1970).
18. LA VECCHIA, C., NEGRI, E., FRANCESCHI, S., D'AVANZO, B. and BOYLE, P., A case-control study of diabetes mellitus and cancer risk. Brit. J. Cancer, 70, 950-953 (1994).
19. LEE, S.A., KARASZKIEWICZ, J.W. and ANDERSON, W.B., Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. Cancer Res., 52, 3750-3759 (1992).
20. MEYER, T., REGENASS, U., FABBRO, D., ALTERI, E., ROSEL, J., MULLER, M., CARAVATTI, G. and MATTER, A., A derivative of staurosporine (CG41251) shows selectivity for protein kinase C inhibition and in vitro antiproliferative as well as in in vivo anti-tumor activity. Int. J. Cancer, 43, 851-856 (1989).
21. NISHIZUKA, Y., The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond.), 334, 661-665 (1988).
22. PATEL, N.A., CHALFANT, C.E., YAMAMOTO, M., WATSON, J.E., EICHLER, D.C. and COOPER, D.R., Acute hyperglycemia regulates transcription and posttranscriptional stability of PKCβII mRNA in vascular smooth muscle cells. FASEB J. 13, 103-113 (1999).
23. TALAMINI, R., FRANCESCHI, S., FAVERO, A., NEGRI, E., PARAZZINI, F. and LA VECCHIA, C., Selected medical conditions and risk of breast cancer. Brit. J. Cancer, 75, 1699-1703 (1997).
24. WAYS, D.K., KUKOLY, C.A., DE VENTE, J., HOOKER, J.L., BRYANT, W.O., POSEKANY, K.J., FLETCHER, D.J., COOK, P.P. and PARKER, P.J., MCF-7 breast cancer cells transfected with protein kinase C-α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J. clin. Invest., 95, 1906-1915 (1995).
25. WEIDERPASS, E., GRIDLEY, G., PERSSON, I., NYREN, O., EKBOM, A. and ADAMI, H.-O., Risk of endometria] and breast cancer in patients with diabetes mellitus. Int. J. Cancer, 71, 360-363 (1997).
26. YAMAMOTO, M., ACEVEDO-DUNCAN, M., CHALFANT, C.E., PATEL, N.A., WATSON, J.E. and COOPER, D.R., Regulation of protein kinase C in vascular smooth muscle cells: involvement of βI and βII isozyme in cell proliferation. Exp. Cell Res., 240, 349-358 (1998a).
27. YAMAMOTO, M., PATEL, N.A. and COOPER, D.R., The involvement of protein kinase C-βII in glucose-induced rat vascular smooth muscle cell proliferation. J. Anti-Aging Med., 1, 205-216 (1998b).