Sivelestat reduces myocardial ischemia and reperfusion injury in rat hearts even when administered after onset of myocardial ischemia

Interactive Cardiovascular and Thoracic Surgery

Volumn 8, Issue 6, 2009, Pages 629-634

  Kambe, Masaru ^a,b   Bessho, Ryuzo ^a   Fujii, Masahiro ^a   Ochi, Masami ^a   Shimizu, Kazuo ^a  

^a NIPPON MEDICAL SCHOOL GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NIPPON MEDICAL SCHOOL CHIBA HOKUSOH HOSPITAL   (Japan)

Author keywords

Endothelium; Ischemia reperfusion; Myocardial protection

Indexed keywords

ACETYLCHOLINE; SIVELESTAT; TROPONIN T;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE PRESSURE; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ACETYLCHOLINE; ANIMALS; CARDIOTONIC AGENTS; CORONARY CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GLYCINE; LEUKOCYTE ELASTASE; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; PERFUSION; RATS; RATS, WISTAR; SERINE PROTEINASE INHIBITORS; SULFONAMIDES; TROPONIN T; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 66849138421     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1510/icvts.2008.195933     Document Type: Article

References (15)

1. Vinten-Johansen J, Edgerton TA, Howe HR, Gayheart PA, Mills SA, Howard G, Cordell AR. Immediate functional recovery and avoidance of reperfusion injury with surgical revascularization of short-term coronary occlusion. Circulation 1985;72:431-439. (Pubitemid 15019893)
2. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007;357:1121-1135. (Pubitemid 47443217)
3. Hoshi K, Kurosawa S, Kato M, Andoh K, Satoh D, Kaise A. Sivelestat, a neutrophil elastase inhibitor, reduces mortality rate of critically ill patients. Tohoku J Exp Med 2005;207:143-148. (Pubitemid 41601029)
4. Isikawa N, Oda M, Kawaguchi M, Tsunezuka Y, Watanabe G. The effects of a specific neutrophil elastase inhibitor (ONO-5046) in pulmonary ischemia-reperfusion injury. Transpl Int 2003;16:341-346. (Pubitemid 36733746)
5. Mori H, Nagahiro I, Osaragi T, Kotani K, Nakanishi H, Sano Y, Date H, Shimizu N. Addition of a neutrophil elastase inhibitor to the organ flushing solution decreases lung reperfusion injury in rat lung transplantation. Eur J Cardiothorac Surg 2007;32:791-795. (Pubitemid 47513508)
6. Bessho R, Chambers DJ. Myocardial protection: the efficacy of an ultra-short-acting beta-blocker, esmolol, as a cardioplegic agent. J Thorac Cardiovasc Surg 2001;122:993-1003. (Pubitemid 35462668)
7. Tamakuma S, Ogawa M, Aikawa N, Kubota T, Hirasawa H, Ishizaka A, Taenaka N, Hamada C, Matsuoka S, Abiru T. Early phase II clinical study of a neutrophil elastase inhibitor; ONO-5046Na in sepsis patients. Rinsyo Iyaku 1998;14:241-261.
8. Quillen JE, Sellke FW, Brooks LA, Harrison DG. Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels but does not affect large arteries. Circulation 1990;82:586-594. (Pubitemid 20257838)
9. Okajima K, Harada N, Uchiba M, Mori M. Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. Am J Physiol Gastrointest Liver Physiol 2004;287:G1116-G1123. (Pubitemid 39551840)
10. Kono T, Okada S, Saito M. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem 2008;311:87-92.
11. Hein TW, Zhang C, Wang W, Chang CI, Thengchaisri N, Kuo L. Ischemia-reperfusion selectively impairs metric oxide-mediated dilatation in coronary arterioles: counteracting role of arginase. FASEB J 2003;17:2328-2330. (Pubitemid 39561482)
12. Laude K, Thuillez C, Richard V. Coronary endothelial dysfunction after ischemia and reperfusion: a new therapeutic target? Braz J Med Biol Res 2001;34:1-7.
13. Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM. Postconditioning: a form of 'modified reperfusion' protects the myocardium by activating the phosphatidylinositol 3-kinase-akt pathway. Circ Res 2004;95:230-232.
14. Ueno M, Moriyama Y, Toda R, Yotsumoto G, Yamamoto H, Fukumoto Y, Sakasegawa K, Nakamura K, Sakata R. Effect of a neutrophil elastase inhibitor (ONO-5046 Na) on ischemiayreperfusion injury using the left-sided heterotopic canine heart transplantation model. J Heart Lung Transplant 2001;20:889-896. (Pubitemid 32737523)
15. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM. Interleukin-8 as a macrophage-derived mediator of angiogeneses. Science 1992;258:1798-1801.