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Volumn 8, Issue 5, 2009, Pages 1378-1386

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin

Author keywords

[No Author keywords available]

Indexed keywords

MELITTIN; PRODRUG; PROMELITTIN; PROTOXIN; SEPRASE; UNCLASSIFIED DRUG;

EID: 66849125864     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-1170     Document Type: Article
Times cited : (124)

References (37)
  • 1
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • Dvorak HF. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986;315:1650-1659 (Pubitemid 17052899)
    • (1986) New England Journal of Medicine , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 2
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991;64:327-336 (Pubitemid 121001258)
    • (1991) Cell , vol.64 , Issue.2 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 5
    • 0038386685 scopus 로고    scopus 로고
    • Host microenvironment in breast cancer development: Epithelial-cell- stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland
    • Haslam SZ, Woodward TL. Host microenvironment in breast cancer development: epithelial-cell-stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland. Breast Cancer Res 2003;5:208-215
    • (2003) Breast Cancer Res , vol.5 , pp. 208-215
    • Haslam, S.Z.1    Woodward, T.L.2
  • 6
    • 0029353166 scopus 로고
    • Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue
    • Iozzo RV. Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue. Lab Invest 1995;73:157-160
    • (1995) Lab Invest , vol.73 , pp. 157-160
    • Iozzo, R.V.1
  • 9
    • 0030900802 scopus 로고    scopus 로고
    • Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease
    • DOI 10.1074/jbc.272.12.7595
    • Piñeiro-Sánchez ML, Goldstein LA, Dodt J, et al. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. J Biol Chem 1997;272:7595-7601 (Pubitemid 27137306)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.12 , pp. 7595-7601
    • Pineiro-Sanchez, M.L.1    Goldstein, L.A.2    Dodt, J.3    Howard, L.4    Yeh, Y.5    Chen, W.-T.6
  • 12
    • 0036718369 scopus 로고    scopus 로고
    • Reactive stroma in human prostate cancer: Induction of myofibroblast phenotype and extracellular matrix remodeling
    • Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res 2002;8:2912-2923 (Pubitemid 35025739)
    • (2002) Clinical Cancer Research , vol.8 , Issue.9 , pp. 2912-2923
    • Tuxhorn, J.A.1    Ayala, G.E.2    Smith, M.J.3    Smith, V.C.4    Dang, T.D.5    Rowley, D.R.6
  • 13
    • 0037102412 scopus 로고    scopus 로고
    • Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model
    • Cheng JD, Dunbrack RL, Jr., Valianou M, Rogatko A, Alpaugh RK, Weiner LM. Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model. Cancer Res 2002;62:4767-4772 (Pubitemid 34898606)
    • (2002) Cancer Research , vol.62 , Issue.16 , pp. 4767-4772
    • Cheng, J.D.1    Dunbrack Jr., R.L.2    Valianou, M.3    Rogatko, A.4    Alpaugh, R.K.5    Weiner, L.M.6
  • 14
    • 44649110229 scopus 로고    scopus 로고
    • Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium
    • Ghilardi C, Chiorino G, Dossi R, Nagy Z, Giavazzi R, Bani M. Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium. BMC Genomics 2008;9:201.
    • (2008) BMC Genomics , vol.9 , pp. 201
    • Ghilardi, C.1    Chiorino, G.2    Dossi, R.3    Nagy, Z.4    Giavazzi, R.5    Bani, M.6
  • 15
    • 20444421293 scopus 로고    scopus 로고
    • Fibroblast activation protein-α and dipeptidyl peptidase IV (CD26): Cell-surface proteases that activate cell signaling and are potential targets for cancer therapy
    • DOI 10.1016/j.drup.2005.03.002, PII S1368764605000257
    • Kelly T. Fibroblast activation protein-α and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Drug Resist Update 2005;8:51-58 (Pubitemid 40797956)
    • (2005) Drug Resistance Updates , vol.8 , Issue.1-2 , pp. 51-58
    • Kelly, T.1
  • 16
    • 0033579444 scopus 로고    scopus 로고
    • Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
    • DOI 10.1074/jbc.274.51.36505
    • Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ, Rettig WJ. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J Biol Chem 1999;274:36505-36512 (Pubitemid 30005259)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.51 , pp. 36505-36512
    • Park, J.E.1    Lenter, M.C.2    Zimmermann, R.N.3    Garin-Chesa, P.4    Old, L.J.5    Rettig, W.J.6
  • 17
    • 38349169216 scopus 로고    scopus 로고
    • Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites
    • Aggarwal S, Brennen WN, Kole TP, et al. Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites. Biochemistry 2008;47:1076-1086
    • (2008) Biochemistry , vol.47 , pp. 1076-1086
    • Aggarwal, S.1    Brennen, W.N.2    Kole, T.P.3
  • 19
    • 0035967534 scopus 로고    scopus 로고
    • The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: Implication to their mode of action
    • DOI 10.1021/bi0026066
    • Unger T, Oren Z, Shai Y. The effect of cyclization on magainin 2 and melittin analogues on the structure, function, and model membranes interactions: implications to their mode of action. Biochemistry 2001;40:6388-6397 (Pubitemid 32472728)
    • (2001) Biochemistry , vol.40 , Issue.21 , pp. 6388-6397
    • Unger, T.1    Oren, Z.2    Shai, Y.3
  • 21
    • 0035144532 scopus 로고    scopus 로고
    • Structure, location, and lipid perturbations of melittin at the membrane interface
    • Hristova K, Dempsey CE, White SH. Structure, location and lipid perturbations of melittin at the membrane interface. Biophysical J 2001;80:801-811 (Pubitemid 32128331)
    • (2001) Biophysical Journal , vol.80 , Issue.2 , pp. 801-811
    • Hristova, K.1    Dempsey, C.E.2    White, S.H.3
  • 22
    • 0019071218 scopus 로고
    • Stepwise cleavage of the pro part of promelittin by dipeptidylpeptidase 4
    • Kreil G, Haiml L, Suchanek G. Stepwise cleavage of the pro part of promelittin by dipeptidylpeptidase 4. Eur J Biochem 1980;111:49-58.
    • (1980) Eur J Biochem , vol.111 , pp. 49-58
    • Kreil, G.1    Haiml, L.2    Suchanek, G.3
  • 24
    • 33749461961 scopus 로고    scopus 로고
    • A dimeric peptide that binds selectively to prostate-specific membrane antigen and inhibits its enzymatic activity
    • DOI 10.1158/0008-5472.CAN-06-1520
    • Aggarwal S, Singh P, Topaloglu O, Isaacs JT, Denmeade SR. A dimeric peptide that binds selectively to prostate-specific membrane antigen and inhibits its enzymatic activity. Cancer Res 2006;66:9171-9177 (Pubitemid 44521137)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9171-9177
    • Aggarwal, S.1    Singh, P.2    Topaloglu, O.3    Isaacs, J.T.4    Demneade, S.R.5
  • 26
    • 51649087512 scopus 로고    scopus 로고
    • Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts
    • Ostermann E, Garin-Chesa P, Heider KH, et al. Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res 2008;14:4584-4592
    • (2008) Clin Cancer Res , vol.14 , pp. 4584-4592
    • Ostermann, E.1    Garin-Chesa, P.2    Heider, K.H.3
  • 28
    • 2942675473 scopus 로고    scopus 로고
    • Expression and targeting of human fibroblast activation protein in a human skin/severe combined immunodeficient mouse breast cancer xenograft model
    • Tahtis K, Lee FT, Wheatley JM, et al. Expression and targeting of human fibroblast activation protein in a human skin/severe combined immunodeficient mouse breast cancer xenograft model. Mol Cancer Ther 2003;2:729-737
    • (2003) Mol Cancer Ther , vol.2 , pp. 729-737
    • Tahtis, K.1    Lee, F.T.2    Wheatley, J.M.3
  • 30
    • 0037219532 scopus 로고    scopus 로고
    • Stromal antigen targeting by a humanised monoclonal antibody: An early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer
    • Hofheinz RD, al-Batran SE, Hartmann F, et al. Stromal antigen targeting by a humanised monoclonal antibody: an early phase II trial of sibrotuzumab in patients with metastatic colorectal cancer. Onkologie 2003;26:44-48
    • (2003) Onkologie , vol.26 , pp. 44-48
    • Hofheinz, R.D.1    Al-Batran, S.E.2    Hartmann, F.3
  • 31
    • 3442900472 scopus 로고    scopus 로고
    • PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism
    • DOI 10.1158/0008-5472.CAN-04-0447
    • Adams S, Miller GT, Jesson MI, Watanabe T, Jones B, Wallner BP. PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res 2004;64:5471-5480 (Pubitemid 39006571)
    • (2004) Cancer Research , vol.64 , Issue.15 , pp. 5471-5480
    • Adams, S.1    Miller, G.T.2    Jesson, M.L.3    Watanabe, T.4    Jones, B.5    Wallner, B.P.6
  • 34
    • 0035915797 scopus 로고    scopus 로고
    • Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast
    • DOI 10.1002/1097-0215(20010120)95:1<67::AID-IJC1012>3.0.CO;2-U
    • Ariga N, Sato E, Ohuchi N, Nagura H, Ohtani H. Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast. Int J Cancer 2001;95:67-72. (Pubitemid 32118615)
    • (2001) International Journal of Cancer , vol.95 , Issue.1 , pp. 67-72
    • Foote, J.A.1    Harris, R.B.2    Giuliano, A.R.3    Roe, D.J.4    Moon, T.E.5    Cartmel, B.6    Alberts, D.S.7
  • 36
    • 33644765198 scopus 로고    scopus 로고
    • Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug
    • DOI 10.1002/pros.20348
    • Janssen S, Rosen DM, Ricklis RM, et al. Pharmacokinetics, biodistribution, and antitumor efficacy of a human glandular kallikrein 2 (hK2)-activated thapsigargin prodrug. Prostate 2006;66:358-368 (Pubitemid 43346946)
    • (2006) Prostate , vol.66 , Issue.4 , pp. 358-368
    • Janssen, S.1    Rosen, D.M.2    Ricklis, R.M.3    Dionne, C.A.4    Lilja, H.5    Christensen, S.B.6    Isaacs, J.T.7    Denmeade, S.R.8
  • 37
    • 21644470680 scopus 로고    scopus 로고
    • Use of methotrexate-based peptide substrates to characterize the substrate specificity of Prostate-Specific Membrane Antigen (PSMA)
    • Mhaka A, Gady AM, Rosen DM, Lo KM, Gillies SD, Denmeade SR. Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA). Cancer Biol Ther 2004;3:551-558 (Pubitemid 41351127)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.6 , pp. 551-558
    • Mhaka, A.1    Gady, A.M.2    Rosen, D.M.3    Lo, K.-M.4    Gillies, S.D.5    Denmeade, S.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.