Lethal intravenous infusion of a wound antiseptic containing polyhexanide;Tödliche intravenöse infusion eines polyhexanidhaltigen wundantiseptikums

Archiv fur Kriminologie

Volumn 223, Issue 3-4, 2009, Pages 108-116

  Wehner, Frank ^a   Wehner, Heinz Dieter ^a   Schulz, Martin Manfred ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Liver damage; Polyhexanide; Wound antiseptic

Indexed keywords

POLY(HEXAMETHYLENEBIGUANIDE); BIGUANIDE DERIVATIVE; DISINFECTANT AGENT;

AGED; ANTISEPSIS; ARTICLE; CASE REPORT; FATALITY; FEMALE; HISTOCOMPATIBILITY; HUMAN; LETHALITY; LIVER INJURY; PANCREAS INJURY; WOUND CARE; ACUTE HEMORRHAGIC PANCREATITIS; AUTOPSY; CENTRAL VENOUS CATHETERIZATION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; LEGAL ASPECT; LIVER; MEDICATION ERROR; PANCREAS; PATHOLOGY; SOFT TISSUE INFECTION; TOXIC HEPATITIS;

AGED, 80 AND OVER; AUTOPSY; BIGUANIDES; CATHETERIZATION, CENTRAL VENOUS; DISINFECTANTS; FATAL OUTCOME; FEMALE; HEPATITIS, TOXIC; HUMANS; INFUSIONS, INTRAVENOUS; LIVER; MEDICATION ERRORS; PANCREAS; PANCREATITIS, ACUTE NECROTIZING; SOFT TISSUE INFECTIONS;

EID: 66849125716     PISSN: 00039225     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Baumanis, E. A., Birska, I. A., Zakenfeld, G. K., Volkova, V. V., Luksha, U. E.: Cytological and immunological aspects of the antitumor action of polyhexamethylene guanidine in BALB/c mice. Eksp. Onkol. 11, 66-69 (1989)
2. 14C] polyhexamethylene hydrochloride biguanide. Bull. Environ. Contam. Toxicol. 56, 121-128 (1996)
3. Curd, F. H. S., Rose, F. L.: Synthetic antimalarials. Part X. Some aryl-diguanide ("-biguanide") derivatives. J. Chem. Soc. 68, 729-773 (1946)
4. Ernst, D., Schwalbach, P., Hillmeier, J., Kock, H. J.: In vitro Untersuchung zur Wirkung des Antiseptikums Lavasept auf Knochengewebe. German Medical Science (Düsseldorf/Köln), Doc 03dguF3-6 (2003)
5. Fiscella, R. G., Moshifar, M., Messick, C. R., Pendland, S. L., Chandler, J. W., Viana, M.: Polyhexamethylene biguanide (PHMB) in the treatment of experimental Fusarium keratomycosis. Cornea 16, 447-449 (1997) (Pubitemid 27282184)
6. Grunst, J., Teilken, M., Dobbelstein, H., Eisenburg, J.: Metabolische Wirkungen von Phenylaethylbiguanid (Phenformin) auf die hämoglobinfrei perfundierte Rattenleber. Res. Exp. Med. (Berlin) 159, 99-107 (1972)
7. Ikeda, T., Yamaguchi, H., Tazuke, S.: New polymeric biocides: synthesis and antibacterial activities of polycations with pendant biguanide groups. Antimicrob. Agents Chemother. 26, 139-144 (1984)
8. Ikeda, T., Ledwith, A., Bamford, C. H., Hann, R. A.: Interaction of a polymeric biguanide biocide with phospholipid membranes. Biochim. Biophys. Acta 769, 57-66 (1984)
9. Jost, U., Böhrer, H.: Metformin - Sinn oder Unsinn einer Therapieumstellung in der perioperativen Phase. Anästhesiol. Intensivmed. Notfallmed. Schmerzther. 37, 461-446 (2002)
10. Kalteis, T., Lüring, C., Schaumburger, J., Perlick, L., Bäthis, H., Grifka, J.: Gewebetoxizität lokaler Antiseptika. Z. Orthop. Unfallchir. 141, 233-238 (2003)
11. Lin, J. C., Ward, T. P., Belyea, D. A., McEvoy, P., Kramer, K. K.: Treatment of Nocardia asteroides keratitis with polyhexamethylene biguanide. Ophthalmology 104, 130-1311 (1997) (Pubitemid 28048728)
12. Majic-Todt, A.: Prüfung von Lavasept auf antiseptische Effektivität und Plaquehemmung. Diss. Univ. Greifswald (2003)
13. Marelli, G., Papaleo, E., Origoni, M., Caputo, L., Ferrari, A.: Polyhexamethylene biguanide for treatment of external genital warts: a prospective, double-blind, randomized study. Eur. Rev. Med. Pharmacol. Sci. 9, 369-372 (2005)
14. Neuberger, J., Emmert, R., Ries, M.: Asymptomatische kortikale Kleinhirnatrophie nach Intoxikation bei akzidenteller, intravenöser Gabe eines Antiseptikums. 30. Jahrestag. Ges. f. Neuropädiatrie, Bern (25.-27.03.2004), P 96
15. Olivieri, J., Eigenmann, P. A., Hauser, C.: Severe anaphylaxis to a new disinfectant: polyhexanide, a chlorhexidine polymer. Schweiz. Med. Wochenschr. 128, 1508-1511 (1998)
16. Prajna, N. V., Anitha, M., Divya, R., George, C., Srinivasan, M.: Effect of topical 0.02% polyhexamethylene biguanide on nocardial keratitis associated with scleritis. Indian J. Ophthalmol. 46, 251-252 (1998)
17. Rose, F. L., Swain, G.: Bisdiguanides having antibacterial activity. J. Chem. Soc. Part IV, 4422-4425 (1956)
18. Santodomingo-Rubido, J.: The comparative clinical performance of a new polyhexamethylene biguanide - vs a polyquad-based contact lens care regime with two silicone hydrogel contact lenses. Ophthalmic Physiol. Opt. 27, 168-173 (2007)
19. Schäfer, G.: Interaction of biguanides with mitochondrial and synthetic membranes. Eur. J. Biochem. 45, 57-58 (1974)
20. Schmit-Neuerburg, K. P., Bettag, C., Schlickewei, W., Fabry, W., Hanke, J., Renzing-Kohler, K., Hirche, H., Kock, H. J.: Effectiveness of an improved antiseptic in treatment of contaminated soft tissue wounds. Chirurg 72, 61-71 (2001) (Pubitemid 33681889)
21. Schnuch, A., Geier, J., Uter, W., Basketter, D. A., Jowsey, I. R.: The biocide polyhexamethylene biguanide remains an uncommon contact allergen. Contact Dermatitis 56, 235-239 (2007)
22. Tien, S. H., Sheu, M. M.: Treatment of Acanthamoeba keratitis combined with fungal infection with polyhexamethylene biguanide. Kaohsiung J. Med. Sci. 15, 665-673 (1999)
23. Welk, A., Splieth, C. H., Schmidt-Martens, G., Schwahn, Ch., Kocher, T., Kramer, A., Rosin, M.: The effect of a polyhexamethylene biguanide mouthrinse compared with a triclosan rinse and a Chlorhexidine rinse on bacterial counts and 4-day plaque re-growth. J. Clin. Periodontol. 32, 499-505 (2005)