Role of serotonin1A receptors on the modulation of rat spinal mono-synaptic reflexes in vitro

Neuroscience Letters

Volumn 334, Issue 1, 2002, Pages 41-44

  Hedo, Gonzalo ^a   Ajubita, Mar ^a   Lopez Garcia, Jose A ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Mono synaptic reflex; Nociceptive reflex; Serotonin; Serotonin1A receptors; Spinal pathways

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 CARBAMOYLTRYPTAMINE; 5-CARBOXAMIDOTRYPTAMINE; DRUG DERIVATIVE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PIPERAZINE DERIVATIVE; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; RECEPTOR SUBTYPE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; TETRALIN DERIVATIVE;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DRUG EFFECT; ELECTROSTIMULATION; MONOSYNAPTIC REFLEX; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; RAT; SPINAL CORD; SPINAL ROOT; WISTAR RAT; ANIMAL TISSUE; CONTROLLED STUDY; DEPOLARIZATION; DORSAL ROOT; IN VITRO STUDY; MODULATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SPINAL REFLEX; VENTRAL ROOT;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ELECTRIC STIMULATION; ORGAN CULTURE TECHNIQUES; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; REFLEX, MONOSYNAPTIC; SEROTONIN; SEROTONIN AGENTS; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPINAL CORD; SPINAL NERVE ROOTS;

EID: 0037032542     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)01064-9     Document Type: Article

References (18)

1. Bras H., Jankowska E., Noga B., Skoog B. Comparison of effects of various types of NA and 5-HT agonists on transmission from group II muscle afferents in the cat. Eur. J. Neurosci. 2:1990;1029-1039.
2. Clarke R.W., Harris J., Houghton A.K. Spinal 5-HT-receptors and tonic modulation of transmission through a withdrawal reflex pathway in the decerebrated rabbit. Br. J. Pharmacol. 119:1996;1167-1176.
3. Cliffe I.A., Brightwell C.I., Fletcher A., Forster E.A., Mansell H.L., Reilly Y., Routledge C., White A.C. (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J. Med. Chem. 36:1993;1509-1510.
4. Crick H., Wallis D.I. Inhibition of reflex responses of neonate rat lumbar spinal cord by 5-hydroxytryptamine. Br. J. Pharmacol. 103:1991;1769-1775.
5. Crick H., Manuel N.A., Wallis D.I. A novel 5-HT receptor or a combination of 5-HT receptor subtypes may mediate depression of a spinal monosynaptic reflex in vitro. Neuropharmacology. 33:1994;897-904.
6. Elliott P., Wallis D.I. Serotonin and L-norepinephrine as mediators of altered excitability in neonatal rat motoneurons studied in vitro. Neuroscience. 47:1992;533-544.
7. Fletcher A., Bill D.J., Bill S.J., Cliffe I.A., Dover G.M., Forster E.A., Haskins J.T., Jones D., Mansell H.L., Reilly Y. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur. J. Pharmacol. 237:1993;283-291.
8. Hedo G., Laird J.M., Lopez-Garcia J.A. Time-course of spinal sensitization following carrageenan-induced inflammation in the young rat: a comparative electrophysiological and behavioural study in vitro and in vivo. Neuroscience. 92:1999;309-318.
9. Hedo G., Lopez-Garcia J.A. 5-HT1B but not 5-HT6 or 5-HT7 receptors mediate depression of spinal nociceptive reflexes in vitro. Br. J. Pharmacol. 135:2002;935-942.
10. Honda M., Ono H. Differential effects of (R)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on the monosynaptic spinal reflex in rats. Eur. J. Pharmacol. 373:1999;171-179.
11. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 46:1994;157-203.
12. Manuel N.A., Wallis D.I., Crick H. Ketanserin-sensitive depressant actions of 5-HT receptor agonists in the neonatal rat spinal cord. Br. J. Pharmacol. 116:1995;2647-2654.
13. Millan M.J. The role of descending noradrenergic and serotonergic pathways in the modulation of nociception: focus on receptor multiplicity. Dickenson A., Besson J.M., The Pharmacology of Pain. 1997;385-446 Springer-Verlag, Berlin.
14. Rajaofetra N., Sandillon F., Geffard M., Privat A. Pre- and post-natal ontogeny of serotonergic projections to the rat spinal cord. J. Neurosci. Res. 22:1989;305-321.
15. Schmidt B.J., Jordan L.M. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res. Bull. 53:2000;689-710.
16. Thompson S.W., Dray A., Urban L. Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro. J. Neurosci. 14:1994;3672-3687.
17. Wallis D.I., Wu J. FAST and SLOW ipsilateral and contralateral spinal reflexes in the neonate rat are modulated by 5-HT. Gen. Pharmacol. 23:1992;1035-1044.
18. Yomono H.S., Suzuki H., Yoshioka K. Serotonergic fibers induce a long-lasting inhibition of monosynaptic reflex in the neonatal rat spinal cord. Neuroscience. 47:1992;521-531.