IL-12 suppression, enhanced endocytosis and up-regulation of MHC-II and CD80 in dendritic cells during experimental endotoxin tolerance

Acta Pharmacologica Sinica

Volumn 30, Issue 5, 2009, Pages 582-588

  Zhang, Jing ^a   Qu, Jie Ming ^a   He, Li Xian ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Co stimulatory molecules; Dendritic cells; Endocytosis; Endotoxin tolerance; Interleukin 12; MHC II

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; MALE; MOUSE; NONHUMAN; UPREGULATION;

ANIMALS; ANTIGENS, CD80; BONE MARROW CELLS; CELLS, CULTURED; DENDRITIC CELLS; DESENSITIZATION, IMMUNOLOGIC; ENDOCYTOSIS; ENDOTOXINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-12; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 66749144278     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.34     Document Type: Article

References (36)

1. Cazzola M, Matera MG, Pezzuto G. Infammation-a new therapeutic target in pneumonia. Respiration 2005; 72: 117-26.
2. Morrison DC, Ryan JL. Endotoxins and disease mechanisms. Annu Rev Med 1987; 38: 417-32.
3. Miyake K. Endotoxin recognition molecules MD-2 and tolllike receptor 4 as potential targets for therapeutic intervention of endotoxin shock. Curr Drug Targets Inflamm Allergy 2004; 3: 291-7.
4. Axtelle T, Pribble J. An overview of clinical studies in healthy subjects and patients with severe sepsis with IC14, a CD14-specifc chimeric monoclonal antibody. J Endotoxin Res 2003; 9: 385-9.
5. West MA, Heagy W. Endotoxin tolerance: a review. Crit Care Med 2002; 30: S64-73.
6. El Gazzar M, Yoza BK, Hu JY, Cousart SL, McCall CE. Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. J Biol Chem 2007; 282: 26857-64.
7. Chae BS. Comparative study of the endotoxemia and endotoxin tolerance on the production of Th cytokines and macrophage interleukin-6: diferential regulation of indomethacin. Arch Pharm Res 2002; 25: 910-6.
8. Qu J, Zhang J, Pan J, He L, Ou Z, Zhang X, et al. Endotoxin tolerance inhibits lipopolysaccharide-initiated acute pulmonary infammation and lung injury in rats by the mechanism of nuclear factor-kappaB. Scand J Immunol 2003; 58: 613-9.
9. Sanchez-Cantu L, Rode HN, Christou NV. Endotoxin tolerance is associated with reduced secretion of tumor necrosis factor. Arch Surg 1989;124:1432-5; discussion 1435-6.
10. Flohe S, Dominguez Fernandez E, Ackermann M, Hirsch T, Borgermann J, Schade FU. Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 and HSP70 in lung and liver during endotoxin shock. Cytokine 1999; 11: 796-804.
11. Zingarelli B, Hake PW, Cook JA. Inducible nitric oxide synthase is not required in the development of endotoxin tolerance in mice. Shock 2002; 17: 478-84.
12. Lehner MD, Hartung T. Endotoxin tolerance-mechanisms and beneficial effects in bacterial infection. Rev Physiol Biochem Pharmacol 2002; 144: 95-141.
13. Rayhane N, Fitting C, Lortholary O, Dromer F, Cavaillon JM. Administration of endotoxin asociated with lipopolysaccharide tolerance protects mice against fungal infection. Infect Immun 2000; 68: 3748-53.
14. Ueno H, Klechevsky E, Morita R, Aspord C, Cao T, Matsui T, et al. Dendritic cell subsets in health and disease. Immunol Rev 2007; 219: 118-42.
15. Montoya M, Edwards MJ, Reid DM, Borrow P. Rapid activation of spleen dendritic cell subsets following lymphocytic chorio-meningitis virus infection of mice: analysis of the involvement of type 1 IFN. J Immunol 2005; 174: 1851-61.
16. Bozza S, Gaziano R, Spreca A, Bacci A, Montagnoli C, di Francesco P, et al. Dendritic cells transport conidia and hyphae of Aspergillus fumigatus from the airways to the draining lymph nodes and initiate disparate T responses to the fungus. J Immunol 2002; 168: 1362-71.
17. Pulendran B, Palucka K, Banchereau J. Sensing pathogens and tuning immune responses. Science 2001; 293: 253-6.
18. Pulendran B. Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol 2005; 174: 2457-65.
19. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992; 176: 1693-702.
20. Mathison JC, Virca GD, Wolfson E, Tobias PS, Glaser K, Ulevitch RJ. Adaptation to bacterial lipopolysaccharide controls lipopo-lysaccharide-induced tumor necrosis factor production in rabbit macrophages. J Clin Invest 1990; 85: 1108-18.
21. Wilhelm W, Grundmann U, Rensing H, Werth M, Langemeyer J, Stracke C, et al. Monocyte deactivation in severe human sepsis or following cardiopulmonary bypass. Shock 2002; 17: 354-60.
22. Heagy W, Nieman K, Hansen C, Cohen M, Danielson D, West MA. Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients. Surg Infect (Larchmt) 2003; 4: 171-80.
23. Cavaillon JM, Adib-Conquy M. Bench-to-bedside review: endo-toxin tolerance as a model of leukocyte reprogramming in sepsis. Crit Care 2006; 10: 233-41.
24. Wang XD, Qu JM, Zhang J, Ou ZL, Pan J. Inhibition of Pseudo-monas aeruginosa initiated lung infammation in endo toxin tolerant rats. Fudan Acad J (Medical Version) 2005; 32: 13-6. Chinese.
25. Lehner MD, Ittner J, Bundschuh DS, van Rooijen N, Wendel A, Hartung T. Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica Serovar Typhimurium infection despite attenuated cytokine response. Infect Immun 2001; 69: 463-71.
26. Wheeler DS, Lahni PM, Denenberg AG, Poynter SE, Wong HR, Cook JA, et al. Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis. Shock 2008; 30: 267-73.
27. Muthukuru M, Cutler CW. Antigen capture of Porphyromonas gingivalis by human macrophages is enhanced but killing and antigen presentation are reduced by endotoxin tolerance. Infect Immun 2008; 76: 477-85.
28. Wysocka M, Robertson S, Riemann H, Caamano J, Hunter C, Mackiewicz A, et al. IL-12 suppression during experimental endotoxin tolerance: dendritic cell loss and macrophage hypo-respon siveness. J Immunol 2001; 166: 7504-13.
29. Kang BY, Kim E, Kim TS. Regulatory mechanisms and their therapeutic implications of interleukin-12 production in immune cells. Cell Signal 2005; 17: 665-73.
30. Nakahara T, Moroi Y, Uchi H, Furue M. Differential role of MAPK signaling in human dendritic cell maturation and T1/T2 engagement. J Dermatol Sci 2006; 42: 1-11.
31. Merlin T, Sing A, Nielsen PJ, Galanos C, Freudenberg MA. Inherited IL-12 unresponsiveness contributes to the high LPS resistance of the Lps(d) C57BL/10ScCr mouse. J Immunol 2001; 166: 566-73.
32. Balkhy HH, Heinzel FP. Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: defciencies in both IL-12 heterodimer production and IL-12 responsiveness. J Immunol 1999; 162: 3633-8.
33. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767-811.
34. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-52.
35. Alvarez D, Vollmann EH, von Andrian UH. Mechanisms and consequences of dendritic cells migration. Immunity 2008; 29: 325-42.
36. Foster SL, Hargreaves DC, Medzhitov HR. Gene-specifc control of infammation by TLR-induced chromatin modifcations. Nature 2007; 447: 972-8. Corrected from: Nature 2008; 451: 102.