Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 3, 2009, Pages 959-966

  Selvendiran, Karuppaiyah ^a   Kuppusamy, M Lakshmi ^a   Bratasz, Anna ^a   Tong, Liyue ^a   Rivera, Brian K ^a   Rink, Cameron ^b   Sen, Chandan K ^b   Kálai, Tamás ^c   Hideg, Kálmán ^c   Kuppusamy, Periannan ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF PÉCS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 BIS[(4 FLUOROPHENYL)METHYLIDENE] 1 [(1 HYDROXY 2,2,5,5 TETRAMETHYL 2,5 DIHYDRO 1H PYRROL 3 YL)METHYL]PIPERIDIN 4 ONE; GELATINASE A; GELATINASE B; HO 3867; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIPERIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA MEDIA; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY INJURY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESTENOSIS; VASCULAR SMOOTH MUSCLE;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; APOPTOSIS; BENZYLIDENE COMPOUNDS; CAROTID ARTERIES; CASPASE 3; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CORONARY RESTENOSIS; CURCUMIN; G1 PHASE; GENE EXPRESSION; GROWTH INHIBITORS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MOLECULAR STRUCTURE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; PIPERIDONES; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

EID: 66749120908     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.150367     Document Type: Article

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