Discovery of the development candidate N-tert-butyl nodulisporamide: A safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals

Journal of Medicinal Chemistry

Volumn 52, Issue 11, 2009, Pages 3505-3515

  Meinke, Peter T ^a   Colletti, Steven L ^a   Fisher, Michael H ^a   Wyvratt, Matthew J ^a   Shih, Thomas L ^a,b   Ayer, Michelle B ^a   Li, Chunshi ^a   Lim, Julie ^a   Ok, Dong ^a   Salva, Steve ^a   Warmke, Lynn M ^a   Zakson, Michelle ^a   Michael, Bruce F ^a   DeMontigny, Pierre ^a   Ostlind, Dan A ^a   Fink, David ^a   Drag, Marlene ^a   Schmatz, Dennis M ^a   Shoop, Wesley L ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b J Star Research Inc   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; FIPRONIL; IMIDACLOPRID; N (1 FLUOROMETHYL) 2 FLUOROETHYLNODULISPORAMIDE; N (1,1 DIMETHYL) 2 OXOPROPYLNODULISPORAMIDE; N (1,1 DIMETHYL)CARBOMETHOXYMETHYLNODULISPORAMIDE; N (1,1 DIMETHYL)PROPARG 2 YLNODULISPORAMIDE; N (1,1,2,2 TETRAMETHYL)HYDROXYETHYLNODULISPORAMIDE; N (2 METHYL)PROPEN 2 YLNODULISPORAMIDE; N (3,3,3 TRIFLUORO) N PROPYLNODULISPORAMIDE; N (4 METHOXY)BENZYLNODULISPORAMIDE; N 2,2,2 TRIFLUOROETHYLNODULISPORAMIDE; N CYCLOPROPYLMETHYLNODULISPORAMIDE; N ISOBUTYLNODULISPORAMIDE; N ISOPROPYLNODULISPORAMIDE; N TERT BUTYLNODULISPORAMIDE; NODULISPORIC ACID A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAT; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; EXPERIMENTAL MODEL; FEMALE; FLEA; INSECT CONTROL; MALE; MOUSE; NONHUMAN; PARASITE CONTROL; SINGLE DRUG DOSE; TICK; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ADMINISTRATION, ORAL; ANIMALS; CATS; DOGS; FEMALE; INDOLE ALKALOIDS; INDOLES; INSECT CONTROL; INSECTICIDES; MALE; MICE; SIPHONAPTERA; TICKS; TISSUE DISTRIBUTION;

EID: 66749114884     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801334v     Document Type: Article

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