Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia

Clinical Cancer Research

Volumn 15, Issue 11, 2009, Pages 3834-3841

  Schardt, Julian A ^a   Weber, Daniel ^a   Eyholzer, Marianne ^a   Mueller, Beatrice U ^a   Pabst, Thomas ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALRETICULIN; CD135 ANTIGEN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LACTATE DEHYDROGENASE; MESSENGER RNA; X BOX BINDING PROTEIN 1;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CHROMOSOME 7; CHROMOSOME DELETION; CONTROLLED STUDY; DISEASE COURSE; ENDOPLASMIC RETICULUM; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN VARIANT; RNA SPLICING;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ALTERNATIVE SPLICING; CALRETICULIN; CCAAT-ENHANCER-BINDING PROTEINS; CHROMOSOME ABERRATIONS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HEAT-SHOCK PROTEINS; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; MOLECULAR CHAPERONES; MUTATION; PROGNOSIS; PROTEIN FOLDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SURVIVAL ANALYSIS; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 66649101565     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-2870     Document Type: Article

References (30)

1. Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 2003;3:89-101. (Pubitemid 37328876)
2. Ni M, Lee AS. ER chaperones in mammalian development and human diseases. FEBS Lett 2007;581:3641-3651 (Pubitemid 47082516)
3. Schroder M, Kaufman RJ. ER stress and the unfolded protein response. Mutat Res 2005;569:29-63. (Pubitemid 39643256)
4. Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 2004;4:966-977
5. Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006;11:5-13. (Pubitemid 43151639)
6. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007;8:519-529 (Pubitemid 46985379)
7. Shamu CE, Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J 1996;15:3028-3039 (Pubitemid 26187751)
8. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A 2005;102:18773-18784 (Pubitemid 43049523)
9. Zhou J, Liu CY, Back SH, et al. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A 2006;103:14343-14348 (Pubitemid 44484752)
10. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001;107:881-891 (Pubitemid 34084979)
11. Helbling D, Mueller BU, Timchenko NA, et al. The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin. Proc Natl Acad Sci U S A 2004;101:13312-13317 (Pubitemid 39209662)
12. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408 (Pubitemid 34164012)
13. Hirota M, Kitagaki M, Itagaki H, Aiba S. Quantitative measurement of spliced XBP1 mRNA as an indicator of endoplasmic reticulum stress. J Toxicol Sci 2006;31:149-156 (Pubitemid 43894270)
14. Lee AS. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res 2007;67:3496-3499 (Pubitemid 46762126)
15. Li J, Lee AS. Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 2006;6:45-54.
16. Dong D, Ni M, Li J, et al. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene- induced mammary tumor development. Cancer Res 2008;68:498-505.
17. Daneshmand S, Quek ML, Lin E, et al. Glucoseregulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol 2007;38:1547-1552 (Pubitemid 47418966)
18. Wang HQ, Du ZX, Zhang HY, Gao DX. Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells. Endocrinology 2007;148:3258-3270 (Pubitemid 46996972)
19. Maniratanachote R, Minami K, Katoh M, Nakajima M, Yokoi T. Chaperone proteins involved in troglitazone-induced toxicity in human hepatoma cell lines. Toxicol Sci 2005;83:293-302. (Pubitemid 40227899)
20. Shuda M, Kondoh N, Imazeki N, et al. Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J Hepatol 2003;38:605-614 (Pubitemid 36560645)
21. Davies MP, Barraclough DL, Stewart C, et al. Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int J Cancer 2008;123:85-88
22. Lee E, Nichols P, Spicer D, Groshen S, Yu MC, Lee AS. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res 2006;66:7849-7853 (Pubitemid 44299145)
23. Uramoto H, Sugio K, Oyama T, et al. Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance. Lung Cancer 2005;49:55-62. (Pubitemid 40798093)
24. Khan MM, Nomura T, Chiba T, et al. The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress. J Biol Chem 2004;279:11814-11824 (Pubitemid 38401686)
25. Ng AP, Howe Fong J, Sijin Nin D, et al. Cleavage of misfolded nuclear receptor corepressor confers resistance to unfolded protein response- induced apoptosis. Cancer Res 2006;66:9903-9912 (Pubitemid 44672042)
26. Llewellyn DH, Kendall JM, Sheikh FN, Campbell AK. Induction of calreticulin expression in HeLa cells by depletion of the endoplasmic reticulum Ca2+ store and inhibition of N-linked glycosylation. Biochem J 1996;318:555-560 (Pubitemid 126731744)
27. Timchenko LT, Iakova P, Welm AL, Cai ZJ, Timchenko NA. Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBPpro teins. Mol Cell Biol 2002;22:7242-7257
28. Obeng EA, Carlson LM, Gutman DM, Harrington WJ, Jr., Lee KP , Boise LH. P roteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006;107:4907-4916 (Pubitemid 43882644)
29. Zhou P, Teruya-Feldstein J, Lu P, Fleisher M, Olshen A, Comenzo RL. Calreticulin expression in the clonal plasma cells of patients with systemic light-chain (AL-)amyloidosis is associated with response to high-dose melphalan. Blood 2008;111:549-557
30. Chatterjee S, Hirota H, Belfi CA, Berger SJ, Berger NA. Hypersensitivity to DNA crosslinking agents associated with up-regulation of glucose-regulated stress protein GRP78. Cancer Res 1997;57:5112-5116 (Pubitemid 27498128)