Transcriptional and functional defects of dendritic cells derived from the MUTZ-3 leukaemia line

Immunology

Volumn 127, Issue 3, 2009, Pages 429-441

  Rasaiyaah, Jane ^a   Noursadeghi, Mahdad ^a   Kellam, Paul ^a   Chain, Benjamin ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acute myeloid leukaemia; Antigen presentation; Dendritic cells; Tumour immunity

Indexed keywords

CD14 ANTIGEN; FIBRONECTIN; MESSENGER RNA; TRANSCRIPTOME;

ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW CELL; CANCER IMMUNOTHERAPY; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURFACE; CELL TRANSFORMATION; DENDRITIC CELL; DOWN REGULATION; FLOW CYTOMETRY; GENE CLUSTER; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MONOCYTE; MUTZ 3 CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR IMMUNITY; UNINDEXED SEQUENCE;

ANTIGEN PRESENTATION; ANTIGENS, CD14; CELL DIFFERENTIATION; CELL PROLIFERATION; DENDRITIC CELLS; DOWN-REGULATION; GENE EXPRESSION; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, MYELOID, ACUTE; MULTIGENE FAMILY; POLYMERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONIC ACIDS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 66549099163     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.03018.x     Document Type: Article

References (34)

1. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J Exp Med 1994 179 : 1109 18.
2. Caux C, Dezutter-Dambuyant C, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 1992 360 : 258 61.
3. Rasaiyaah J, Yong K, Katz DR, Kellam P, Chain BM. Dendritic cells and myeloid leukaemias: plasticity and commitment in cell differentiation. Br J Haematol 2007 138 : 281 90.
4. Santegoets SJ, van den Eertwegh AJ, van de Loosdrecht AA, Scheper RJ, de Gruijl TD. Human dendritic cell line models for DC differentiation and clinical DC vaccination studies. J Leukoc Biol 2008 84 : 1364 73.
5. Santegoets SJ, Masterson AJ, Van der Sluis PC et al. A CD34(+) human cell line model of myeloid dendritic cell differentiation: evidence for a CD14(+)CD11b(+) Langerhans cell precursor. J Leukoc Biol 2006 80 : 1337 44.
6. Bontkes HJ, Ruizendaal JJ, Kramer D et al. Constitutively active STAT5b induces cytokine-independent growth of the acute myeloid leukemia-derived MUTZ-3 cell line and accelerates its differentiation into mature dendritic cells. J Immunother 2006 29 : 188 200. (Pubitemid 43756094)
7. Ciraci E, Barisani D, Parafioriti A et al. CD34 human hematopoietic progenitor cell line, MUTZ-3, differentiates into functional osteoclasts. Exp Hematol 2007 35 : 967 77.
8. + precursors. Blood 2002 100 : 701 3.
9. Larsson K, Lindstedt M, Borrebaeck CA. Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells. Immunology 2006 117 : 156 66.
10. Santegoets SJ, Bontkes HJ, Stam AG et al. Inducing antitumor T cell immunity: comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model. J Immunol 2008 180 : 4540 9.
11. Hu ZB, Ma W, Zaborski M, MacLeod R, Quentmeier H, Drexler HG. Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. Leukemia 1996 10 : 1025 40.
12. Welte K, Platzer E, Lu L et al. Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci USA 1985 82 : 1526 30.
13. Alderman CJ, Shah S, Foreman JC, Chain BM, Katz DR. The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radic Biol Med 2002 32 : 377 85.
14. Rad AN, Pollara G, Sohaib SM, Chiang C, Chain BM, Katz DR. The differential influence of allogeneic tumor cell death via DNA damage on dendritic cell maturation and antigen presentation. Cancer Res 2003 63 : 5143 50.
15. Saeed AI, Sharov V, White J et al. TM4: a free, open-source system for microarray data management and analysis. Biotechniques 2003 34 : 374 8.
16. Saldanha AJ. Java Treeview - extensible visualization of microarray data. Bioinformatics 2004 20 : 3246 8.
17. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 2001 98 : 5116 21.
18. Lapidot T, Sirard C, Vormoor J et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994 367 : 645 8.
19. Al Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003 100 : 3983 8.
20. Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 2004 432 : 396 401. (Pubitemid 39551674)
21. Santegoets SJ, Schreurs MW, Masterson AJ et al. In vitro priming of tumor-specific cytotoxic T lymphocytes using allogeneic dendritic cells derived from the human MUTZ-3 cell line. Cancer Immunol Immunother 2006 55 : 1480 90.
22. Kim KD, Choi SC, Noh YW et al. Impaired responses of leukemic dendritic cells derived from a human myeloid cell line to LPS stimulation. Exp Mol Med 2006 38 : 72 84.
23. Azam P, Peiffer JL, Chamousset D et al. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol Appl Pharmacol 2006 212 : 14 23.
24. Swetman CA, Leverrier Y, Garg R et al. Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases. Eur J Immunol 2002 32 : 2074 83.
25. Zilber MT, Setterblad N, Vasselon T et al. MHC class II/CD38/CD9: a lipid-raft-dependent signaling complex in human monocytes. Blood 2005 106 : 3074 81.
26. Luther SA, Bidgol A, Hargreaves DC et al. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol 2002 169 : 424 33.
27. + T cells: possible role in atopic dermatitis. J Invest Dermatol 2006 126 : 1043 51.
28. Pollara G, Speidel K, Samady L et al. Herpes simplex virus infection of dendritic cells: balance among activation, inhibition, and immunity. J Infect Dis 2003 187 : 165 78.
29. Handley ME, Rasaiyaah J, Barnett J et al. Expression and function of mixed lineage kinases in dendritic cells. Int Immunol 2007 19 : 923 33.
30. Holtschke T, Lohler J, Kanno Y et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 1996 87 : 307 17.
31. Gurevich RM, Rosten PM, Schwieger M, Stocking C, Humphries RK. Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia. Exp Hematol 2006 34 : 1192 201.
32. Schmidt M, Nagel S, Proba J et al. Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias. Blood 1998 91 : 22 9.
33. Zhao J, Kong HJ, Li HX et al. IRF-8/interferon (IFN) consensus sequence-binding protein is involved in toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J Biol Chem 2006 281 : 10073 80.
34. Dror N, Alter-Koltunoff M, Azriel A et al. Identification of IRF-8 and IRF-1 target genes in activated macrophages. Mol Immunol 2007 44 : 338 46.