Iron-related proteins: Candidate urine biomarkers in childhood HIV-associated renal diseases

Clinical Journal of the American Society of Nephrology

Volumn 4, Issue 4, 2009, Pages 763-771

  Soler García, Ángel A ^a,b   Johnson, Douglas ^a   Hathout, Yetrib ^a,b   Ray, Patricio E ^a,b  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; ALPHA 1 MICROGLOBULIN; ALPHA1 GLYCOPROTEIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; ANTITHROMBIN III; APOLIPOPROTEIN A1; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CERULOPLASMIN; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; FETUIN A; HAPTOGLOBIN; HEMOPEXIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN KAPPA CHAIN; INTER ALPHA TRYPSIN INHIBITOR; IRON; LACTOFERRIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OROSOMUCOID; PIGMENT EPITHELIUM DERIVED FACTOR; PLASMA RETINOL BINDING PROTEIN; PREALBUMIN; PROTHROMBIN; RETINOL BINDING PROTEIN; TRANSFERRIN; VITAMIN D BINDING PROTEIN; ACUTE PHASE PROTEIN; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; PLASMA PROTEIN;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DISEASE COURSE; DRUG TARGETING; FEMALE; HEMOLYTIC UREMIC SYNDROME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY TUBULE DAMAGE; MALE; NONHUMAN; PATIENT IDENTIFICATION; PROTEIN ANALYSIS; PROTEINURIA; PROTEOMICS; RAT; RISK ASSESSMENT; TRANSGENIC RAT; TWO DIMENSIONAL ELECTROPHORESIS; URINALYSIS; URINE LEVEL; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL; BIOPSY; CASE CONTROL STUDY; DISEASE MODEL; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; PATHOGENICITY; PATHOLOGY; PREDICTION AND FORECASTING; TIME; URINE; VIROLOGY;

ACUTE-PHASE PROTEINS; AIDS-ASSOCIATED NEPHROPATHY; ANIMALS; BIOLOGICAL MARKERS; BIOPSY; BLOOD PROTEINS; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; HAPTOGLOBINS; HEMOLYTIC-UREMIC SYNDROME; HEMOPEXIN; HIV INFECTIONS; HIV-1; HUMANS; IRON; LACTOFERRIN; LIPOCALINS; PREDICTIVE VALUE OF TESTS; PROTEINURIA; PROTO-ONCOGENE PROTEINS; RATS; RATS, TRANSGENIC; TIME FACTORS; TRANSFERRIN;

EID: 66449132962     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.0200608     Document Type: Article

References (50)

1. Chaparro AI, Mitchell CD, Abitbol CL, Wilkinson JD, Baldarragi G, Lopez E, Zilleruelo G: Proteinuria in children infected with the human immunodeficiency virus. J Pediatr 152: 844-849, 2008
2. Ray PE, Lian X, Rakusan T, Liu XH: A 20-year history of childhood HIV-associated nephropathy. Pediatr Nephrol 19: 1075-1092, 2004 (Pubitemid 39317511)
3. Ray PE, Rakusan T, Loechelt BJ, Selby DM, Liu XH, Chandra RS: Human immunodeficiency virus (HIV)-associated nephropathy in children from Washington, DC area: 12 years' experience. Semin Nephrol 18: 396-405, 1998 (Pubitemid 28340463)
4. Turner ME, Kher K, Rakusan T, D'Angelo L, Kapur S, Selby D, Ray PE: Atypical hemolytic uremic syndrome in human immunodeficiency virus-1-infected children. Pediatr Nephrol 11: 161-163, 1997 (Pubitemid 27122683)
5. Strauss J, Abitol C, Zilleruelo G, Scott G, Paredes A, Malaga S, Montane B, Mitchell C, Parks W, Pardo V: Renal disease in children with acquired immunodeficiency syndrome. N Engl J Med 321: 625-630, 1989 (Pubitemid 19221305)
6. Kopp JB, Winkler C: HIV-associated nephropathy in African Americans. Kidney Int 83: S43-S49, 2003
7. Winston J, Klotman PE: HIV-associated nephropathy. Mt Sinai J Med 65: 27-32, 1998
8. Kimmel PL, Phillips TM, Ferreira-Centeno A, Farkas- Szallasi T, Abraham AA, Garrett CT: Brief report: Idiotypic IgA nephropathy in patients with HIV infection. N Engl J Med 327: 702-704, 1992
9. Ray PE, Liu XH: Pathogenesis of Shiga toxin-induced hemolytic uremic Syndrome. Pediatr Nephrol 16: 823-839, 2001 (Pubitemid 32895613)
10. Alpers CE: Light at the end of the TUNEL: HIV-associated thrombotic microangiopathy. Kidney Int 63: 385-396, 2003
11. Varghese SA, Powell TB, Budisavljevic MN, Oates JC, Raymond JR, Almeida JS, Arthus JM: Urine biomarkers predict the cause of glomerular disease. J Am Soc Nephrol 18: 913-922, 2007
12. Vanderver A, Schiffmann E, Timmons M, Kellersberger KA, Fabris D, Hoffman EP, Maletkovic J, Hathout Y: Decreased asialotransferrin in cerebrospinal fluid of patients with childhood-onset ataxia and central nervous system hypomyelination/vanishing white matter disease. Clin Chem 51: 2031-2042, 2005 (Pubitemid 41532618)
13. Jensen ON, Wilm M, Shevchenko A, Mann M: Sample preparation methods for mass spectrometry peptide mapping directly from 2-DE gels. Methods Mol Biol 112: 513-530, 1999
14. Fish WW: Rapid colorimetric micromethod for the quantitation of complexed iron in biological samples. Methods Enzymol 54: 357-364, 1988
15. Ray PE, Liu X-H, Robinson LR, Reid W, Xu J, Owens JW, Jones OD, Denaro F, Davis HG, Bryant JL: A novel HIV-1 transgenic rat model of childhood HIV-1 associated nephropathy. Kidney Int 63: 2242-2253, 2003 (Pubitemid 36605838)
16. Kjeldsen L, Koch C, Arnljots K, Borregaard N: Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils. J Immunol Methods 198: 155-164, 1996 (Pubitemid 26378873)
17. Tobal D, Olascoaga A, Moreira G, Kurdián M, Sánchez F, Roselló M, Alallón W, González Martínez, Noboa O: Rust urine after intense hand drumming is caused by extracor-puscular hemolysis. Clin J Am Soc Nephrol 3: 1022-1027, 2008
18. Rao PV, Lu X, Standley M, Pattee P, Neelima G, Girisesh G, Dakshinamurthy KV, Roberts Jr. CT, Nagalla SR: Proteomic identification of urinary biomarkers of diabetic nephropathy. Diabetes Care 30: 629-637, 2007 (Pubitemid 46354345)
19. Narita T, Sasaki H, Hosoba M, Miura T, Yashioka N, Morii T, Shimotomai T, Koshimura J, Fujita H, Kakei M, Ito S: Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients. Diabetes Care 27: 1176-1181, 2004 (Pubitemid 38579786)
20. Tamano M, Fuke Y, Endo M, Ohsawa I, Fujita T, Ohi H: Urinary complement factor H in renal disease. Nephron 92: 705-707, 2002
21. Delanghe JR, Langlois MR: Hemopexin: A review of biological aspects and the role in laboratory medicine. Clin Chim Acta 312: 13-23, 2001
22. Prinsen BHCMT, De Sain-Vander Velden MGM, Kaysen GA, Straver HWHC, Van Rijn HJM, Stellaard F, Berger Ruud, Rabelink TJ: Transferrin synthesis is increased in nephritic patients insufficiently to replace urinary losses. J Am Soc Nephrol 12: 1017-1025, 2001 (Pubitemid 32378343)
23. Norden AGW, Scheiman SJ, Deschodt-Lanckman MM, Laosley M, Nortier JL, Thakker RV, Unwin RJ, Wrong O: Tubular proteinuria defined by a study of Dent's (CLCN5 mutation) and other tubular diseases. Kidney Int 57: 240-249, 2000
24. Dengler R, Plewan A, Münstermann U, Busch R, Eger G, Emmerich B: Urinary excretion of protelyzed α1-antitrypsin: specificity, quantification, and relation to therapy response in patients with acute myeloid leukemia. Clin Cancer Res 1: 199-205, 1995
25. Yang J, Mori K, Li JY, Barasch J: Iron, lipocalin, and kidney epithelia. Am J Physiol Renal Physiol 285: F9-F18, 2003
26. Zappitelli M, Washburn KK, Arikan AA, Loftis L, Ma Q, Devarajan P, Parikh CR, Goldsten SL: Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: A prospective cohort study. Critical Care 11: R84-R94, 2007
27. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P: Identification of neutrophil-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-2543. 2003 (Pubitemid 37169339)
28. Szczech LA, Grunfeld C, Scherzer R, Canchola JA, van der Horst C, Sidney S, Wohl D, Shlipak MG: Microalbuminuria in HIV infection. AIDS 11: 1003-1009, 2007
29. Guder WG, Hofman W: Markers for the diagnosis and monitoring of renal tubular lesions. Clin Nephrol 38: [Suppl 1]: S3-S7. 1992
30. Shah SV: Role of iron in progressive renal disease. Am J Kidney Dis 37: S30-S33, 2001 (Pubitemid 32048020)
31. Alfrey AC: Toxicity of tubule fluid iron in the nephritic syndrome. Am J Physiol 263: F637-F641, 1992
32. Sponsel HT, Alfrey AC, Hammond WS, Durr JA, Ray C, Anderson RJ: Effect of iron on renal tubular epithelial cells. Kidney Int 50: 436-444, 1996 (Pubitemid 26274370)
33. Fagoonee S, Gburek J, Hirsch E, Marro S, Moestrup SK, Lauberg JM, Chritensen EI, Silengo L, Altruda F, Tolosano E: Plasma protein haptoglobin modulates renal iron loading. Am J Path 166: 973-983, 2005 (Pubitemid 40524423)
34. Yamauchi K, Tomita M, Giehl TJ, Ellison RT III: Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect Immun 61: 719-728, 1993 (Pubitemid 23030865)
35. Machlin LJ, Bendich A: Free radical tissue damage: Protective role of antioxidants. FASEB 1: 441-445, 1987
36. Lim CS, Vaziri ND: The effects of iron dextran on the oxidative stress in cardiovascular tissues of rats with chronic renal failure. Kidney Int 65: 1802-1809, 2004
37. Zhou XJ, Laszik Z, Wang QX, Silva FG, Vaziri NS: Association of renal injury with increased oxygen free radical activity and altered nitiric oxide metabolism in chronic experimental hemosiderosis. Lab Invest 12: 1905-1914, 2000
38. Baliga R, Zhang Z, Baliga M, Ueda N, Shah SV: In vitro and in vivo evidence suggesting a role for iron in ciplastin-induced nephrotocity. Kidney Int 53: 394-401, 1998 (Pubitemid 28097855)
39. Baliga R, Ueda N, Shah SV: Increase in bleomycin-detectable iron in ischemia/reperfusion injury to rat kidneys. Biochem J 191:901-905, 1993 (Pubitemid 23148470)
40. Georgiou NA, van der Bruggen T, Oudshoorn M, Nottet HSLM, Marx JJ, van Asbeck BS: Inhibition of human immunodeficiency virus type 1 replication in human mononuclear blood cells by the iron chelators deferoxime, deferiprone and bleomycin. J Infect Dis 181: 484-490, 2000
41. Gordeuk VR, Delanghe JR, Langlois MR, Boelaert JR: Iron status and the outcome of HIV-infection: An overview. J Clin Virol 20: 111-115, 2001
42. Al-Khafaji B, Kralovic S, Smith RD: Increased hepatic iron in the acquired immunodeficiency syndrome: An autopsy study. Mol Pathol 10: 474-480, 1997 (Pubitemid 27244235)
43. De Monye C, Karcher DS, Boelaer JR, Gordeuk VR: Bone marrow macrophage iron grade and survival of HIV-sero-positive patients. AIDS 13: 375-380, 1999 (Pubitemid 29095100)
44. Savarino A, Pescarmona GP, Boelaert JR: Iron metabolism and HIV infection: Reciprocal interactions with potentially harmful consequences? Cell Biochem Funct 17: 279-287, 1999
45. Jacobus DP: Randomization to iron supplementation of patients with advanced human immunodeficiency virus disease: An inadvertent but controlled study with results important for patient care. J Infect Dis 173: 1044-1045, 1996
46. McDermid JM, Jaye A, Schim vand der Loeff MF, Todd J, Bates C, Austin S, Jeffries D, Awasana AA, Whittlex AA, Prentice A: Elevated iron status strongly predicts mortality in West African adults with HIV infection. J Acquir Immune Defic Syndr 46: 498-507, 2007
47. Ianotti LL, Tielsch HM, Black MM, Black RE: Iron supplementation in early childhood: Health benefits and risks. Am J Clin Nutr 84: 1261-1276, 2006
48. Sembra RD, Gray GE: Pathogenesis of anemia during human immunodeficiency virus infection. J Invest Med 49: 225-239, 2001 (Pubitemid 32479161)
49. Gupta S, Imam A, Licorish K: Serum ferritin in acquired immune deficiency syndrome. J Clin Lab Immunol 20: 11-13, 1986 (Pubitemid 16086451)
50. Lewis DK, Witty CJ, Epino H, Letsky EA, Mukibi JM, van den Broek NR: Interpreting tests for iron deficiency among adults in a high HIV prevalence African setting: Routine tests may lead to misdiagnosis. Trans R Soc Trop Med Hyg 101: 613-617, 2007