Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 12226-12234

  Zhou, Xiangdong ^a   Agazie, Yehenew M ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; BREAST CANCER; CELL TRANSFORMATION; EXTRACELLULAR SIGNAL-REGULATED KINASE; GTPASE-ACTIVATING PROTEIN; MECHANISM OF ACTION; MOLECULAR MECHANISM; NET EFFECT; OVER-EXPRESSION; SH2 DOMAIN; SIGNALING PATHWAYS; SRC-HOMOLOGY; TARGET SITES; THERAPEUTIC TARGETS;

TISSUE CULTURE;

SIGNALING;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS PROTEIN; ERBB2 PROTEIN, HUMAN; ERBB2 PROTEIN, MOUSE; PTPN11 PROTEIN, HUMAN; PTPN11 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; BREAST TUMOR; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; FEMALE; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; HUMANS; MAMMARY NEOPLASMS, ANIMAL; MUTATION; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS C-AKT; RAS GTPASE-ACTIVATING PROTEINS; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 66449118043     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900020200     Document Type: Article

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