Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1763, Issue 1, 2006, Pages 45-56

  Merritt, Rebecca ^a   Hayman, Michael J ^b   Agazie, Yehenew M ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

EGFR; Phosphatase; SHP2; Substrate trapping

Indexed keywords

ALANINE; ARGININE; ASPARTIC ACID; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR; MUTANT ENZYME; MUTANT PROTEIN; ORTHOVANADIC ACID; PROTEIN TYROSINE PHOSPHATASE SHP 2; SERINE; THIOL DERIVATIVE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONSENSUS SEQUENCE; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; MONKEY; MOUSE; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REDUCTION; SITE DIRECTED MUTAGENESIS;

ALANINE; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; CONSENSUS SEQUENCE; COS CELLS; CYSTEINE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MUTATION; NIH 3T3 CELLS; PROTEIN-TYROSINE-PHOSPHATASE; SUBSTRATE SPECIFICITY; THREONINE; VANADATES;

ANIMALIA;

EID: 32144461912     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2005.11.013     Document Type: Article

References (50)

1. J. Schlessinger Cell signaling by receptor tyrosine kinases Cell 103 2000 211 225
2. J. Schlessinger, M. Mohammadi, B. Margolis, and A. Ullrich Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases Cold Spring Harbor Symp. Quant. Biol. 57 1992 67 74
3. A. Sorkin, K. Helin, C.M. Waters, G. Carpenter, and L. Beguinot Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors J. Biol. Chem. 267 1992 8672 8678
4. N.K. Tonks, and B.G. Neel Combinatorial control of the specificity of protein tyrosine phosphatases Curr. Opin. Cell Biol. 13 2001 182 195
5. A. Alonso, J. Sasin, N. Bottini, I. Friedberg, A. Osterman, A. Godzik, T. Hunter, J. Dixon, and T. Mustelin Protein tyrosine phosphatases in the human genome Cell 117 2004 699 711
6. B.G. Neel, and N.K. Tonks Protein tyrosine phosphatases in signal transduction Curr. Opin. Cell Biol. 9 1997 193 204
7. B.G. Neel, H. Gu, and L. Pao The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling Trends Biochem. Sci. 28 2003 284 293
8. G.S. Feng, C.C. Hui, and T. Pawson SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases Science 259 1993 1607 1611
9. G.S. Feng, and T. Pawson Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction Trends Genet. 10 1994 54 58
10. D. D'Ambrosio, K.L. Hippen, S.A. Minskoff, I. Mellman, G. Pani, K.A. Siminovitch, and J.C. Cambier Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1 Science 268 1995 293 297
11. S. Krautwald, D. Buscher, V. Kummer, S. Buder, and M. Baccarini Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway Mol. Cell. Biol. 16 1996 5955 5963
12. S.M. Keyse Protein phosphatases and the regulation of mitogen-activated protein kinase signalling Curr. Opin. Cell Biol. 12 2000 186 192
13. R.J. Lechleider, R.M. Freeman Jr., and B.G. Neel Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2 J. Biol. Chem. 268 1993 13434 13438
14. J.D. Allard, H.C. Chang, R. Herbst, H. McNeill, and M.A. Simon The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf Development 122 1996 1137 1146
15. V. Cleghon, P. Feldmann, C. Ghiglione, T.D. Copeland, N. Perrimon, D.A. Hughes, and D.K. Morrison Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway Mol. Cell 2 1998 719 727
16. A.M. Bennett, S.F. Hausdorff, A.M. O'Reilly, R.M. Freeman, and B.G. Neel Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression Mol. Cell. Biol. 16 1996 1189 1202
17. T.M. Saxton, M. Henkemeyer, S. Gasca, R. Shen, D.J. Rossi, F. Shalaby, G.S. Feng, and T. Pawson Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2 EMBO J. 16 1997 2352 2364
18. T.M. Saxton, B.G. Ciruna, D. Holmyard, S. Kulkarni, K. Harpal, J. Rossant, and T. Pawson The SH2 tyrosine phosphatase shp2 is required for mammalian limb development Nat. Genet. 24 2000 420 423
19. Y.M. Agazie, and M.J. Hayman Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates J. Biol. Chem. 278 2003 13952 13958
20. Z.Y. Zhang, Y. Wang, L. Wu, E.B. Fauman, J.A. Stuckey, H.L. Schubert, M.A. Saper, and J.E. Dixon The Cys(X)5Arg catalytic motif in phosphoester hydrolysis Biochemistry 33 1994 15266 15270
21. J. Yuvaniyama, J.M. Denu, J.E. Dixon, and M.A. Saper Crystal structure of the dual specificity protein phosphatase VHR Science 272 1996 1328 1331
22. L. Xie, Y.L. Zhang, and Z.Y. Zhang Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant Biochemistry 41 2002 4032 4039
23. A.J. Flint, T. Tiganis, D. Barford, and N.K. Tonks Development of and quot;substrate-trapping and quot; mutants to identify physiological substrates of protein tyrosine phosphatases Proc. Natl. Acad. Sci. U. S. A. 94 1997 1680 1685
24. T. Tiganis, A.J. Flint, S.A. Adam, and N.K. Tonks Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97 J. Biol. Chem. 272 1997 21548 21557
25. H. Wheadon, N.R. Paling, and M.J. Welham Molecular interactions of SHP1 and SHP2 in IL-3-signalling Cell. Signal. 14 2002 219 229
26. L.A. Perkins, I. Larsen, and N. Perrimon corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso Cell 70 1992 225 236
27. T. Yi, J.L. Clevel, and J.N. Ihle Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification Blood 78 1991 2222 2228
28. P. Hof, S. Pluskey, S. Dhe-Paganon, M.J. Eck, and S.E. Shoelson Crystal structure of the tyrosine phosphatase SHP-2 Cell 92 1998 441 450
29. A.M. Bilwes, J. den Hertog, T. Hunter, and J.P. Noel Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization Nature 382 1996 555 559
30. R.M. Freeman Jr., J. Plutzky, and B.G. Neel Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew Proc. Natl. Acad. Sci. U. S. A. 89 1992 11239 11243
31. J.M. Denu, and J.E. Dixon A catalytic mechanism for the dual-specific phosphatases Proc. Natl. Acad. Sci. U. S. A. 92 1995 5910 5914
32. C.Y. Park, and M.J. Hayman The tyrosines in the bidentate motif of the env-sea oncoprotein are essential for cell transformation and are binding sites for Grb2 and the tyrosine phosphatase SHP-2 J. Biol. Chem. 274 1999 7583 7590
33. Y.M. Agazie, N. Movilla, I. Ischenko, and M.J. Hayman The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 Oncogene 22 2003 6909 6918
34. S.J. Taylor, and D. Shalloway Cell cycle-dependent activation of Ras Curr. Biol. 6 1996 1621 1627
35. A.M. Bennett, T.L. Tang, S. Sugimoto, C.T. Walsh, and B.G. Neel Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras Proc. Natl. Acad. Sci. U. S. A. 91 1994 7335 7339
36. W. Lu, D. Gong, D. Bar-Sagi, and P.A. Cole Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling Mol. Cell 8 2001 759 769
37. M. Stein-Gerlach, A. Kharitonenkov, W. Vogel, S. Ali, and A. Ullrich Protein-tyrosine phosphatase 1D modulates its own state of tyrosine phosphorylation J. Biol. Chem. 270 1995 24635 24637
38. G. Zhou, J.M. Denu, L. Wu, and J.E. Dixon The catalytic role of Cys124 in the dual specificity phosphatase VHR J. Biol. Chem. 269 1994 28084 28090
39. Z.Y. Zhang, Y. Wang, and J.E. Dixon Dissecting the catalytic mechanism of protein-tyrosine phosphatases Proc. Natl. Acad. Sci. U. S. A. 91 1994 1624 1627
40. W.L. Chen, D.L. Harris, and N.C. Joyce Effects of SOV-induced phosphatase inhibition and expression of protein tyrosine phosphatases in rat corneal endothelial cells Exp. Eye Res. 81 2005 570 580
41. M.C. Zatelli, D. Piccin, F. Tagliati, A. Bottoni, A. Luchin, and E.C. degli Uberti SRC homology-2-containing protein tyrosine phosphatase-1 restrains cell proliferation in human medullary thyroid carcinoma Endocrinology 146 2005 2692 2698
42. Y.M. Agazie, and M.J. Hayman Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling Mol. Cell. Biol. 23 2003 7875 7886
43. A.J. Garton, A.J. Flint, and N.K. Tonks Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST Mol. Cell. Biol. 16 1996 6408 6418
44. J.M. Denu, G. Zhou, Y. Guo, and J.E. Dixon The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase Biochemistry 34 1995 3396 3403
45. H. Deng, R. Callender, Z. Huang, and Z.Y. Zhang Is the PTPase-vanadate complex a true transition state analogue? Biochemistry 41 2002 5865 5872
46. L. Zhu, A. Zilbering, X. Wu, K. Mahadev, J.I. Joseph, S. Jabbour, W. Deeb, and B.J. Goldstein Use of an anaerobic environment to preserve the endogenous activity of protein-tyrosine phosphatases isolated from intact cells FASEB J. 15 2001 1637 1639
47. A. Montagner, A. Yart, M. Dance, B. Perret, J.P. Salles, and P. Raynal A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation J. Biol. Chem. 280 2005 5350 5360
48. K. Kolmodin, and J. Aqvist The catalytic mechanism of protein tyrosine phosphatases revisited FEBS Lett. 498 2001 208 213
49. A.D. Pannifer, A.J. Flint, N.K. Tonks, and D. Barford Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by X-ray crystallography J. Biol. Chem. 273 1998 10454 10462
50. G. Huyer, S. Liu, J. Kelly, J. Moffat, P. Payette, B. Kennedy, G. Tsaprailis, M.J. Gresser, and C. Ramachandran Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate J. Biol. Chem. 272 1997 843 851