GLEPP1/protein-tyrosine phosphatase φ inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11385-11395

  Gobert, Rosanna Pescini ^a   van den Eijnden, Monique ^a   Szyndralewiez, Cedric ^a   Jorand Lebrun, Catherine ^a   Swinnen, Dominique ^a   Chen, Linfeng ^b   Gillieron, Corine ^a   Pixley, Fiona ^c   Juillard, Pierre ^a   Gerber, Patrick ^a   Johnson Léger, Caroline ^a   Halazy, Serge ^a   Camps, Montserrat ^a   Bombrun, Agnes ^a   Shipp, Margaret ^b   Vitte, Pierre Alain ^a   Ardissone, Vittoria ^d   Ferrandi, Chiara ^d   Perrin, Dominique ^a   Rommel, Christian ^a,e   van Huijsduijnen, Rob Hooft ^a   more..

^a MERCK SERONO S A   (Switzerland)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d Istituto di Ricerche Biomediche Antoine Marxer SpA   (Italy)

^e Intellikine Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BONE; DISEASES; MACROPHAGES; MAMMALS; PHOSPHATASES; SALICYLIC ACID; SULFUR COMPOUNDS;

CONTACT HYPERSENSITIVITY; CYTOSKELETAL REARRANGEMENTS; DEXTRAN SULFATE SODIUM; INFLAMMATORY BOWEL DISEASE; MONOCYTE CHEMOTACTIC PROTEIN-1; PHARMACOLOGICAL INHIBITION; PROTEIN-TYROSINE PHOSPHATASE; SELECTIVE INHIBITORS;

BIOCHEMISTRY;

DEXTRAN SULFATE; MONOCYTE CHEMOTACTIC PROTEIN 1; PAXILLIN; PROTEIN KINASE SYK; PROTEIN KINASE SYK 1; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; SALAZOSULFAPYRIDINE; SALICYLIC ACID DERIVATIVE; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG; PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; PTPRO PROTEIN, HUMAN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; THIOGLYCOLIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE COMPARISON; DRUG STRUCTURE; DRUG SYNTHESIS; ENTERITIS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MACROPHAGE FUNCTION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEUM MACROPHAGE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SKIN ALLERGY; ULCERATIVE COLITIS; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; CHEMOTAXIS; CONFORMATION; CYTOSKELETON; DRUG EFFECT; LEUKOCYTE; MACROPHAGE; METABOLISM; MONOCYTE; SIGNAL TRANSDUCTION;

MURINAE; MUS;

ANIMALS; CHEMOTAXIS; COLITIS, ULCERATIVE; CYTOSKELETON; FEMALE; LEUKOCYTES; MACROPHAGES; MICE; MICE, INBRED BALB C; MOLECULAR CONFORMATION; MONOCYTES; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN TYROSINE PHOSPHATASES; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; SIGNAL TRANSDUCTION; THIOGLYCOLATES;

EID: 66449115518     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807241200     Document Type: Article

References (53)

1. Tonks, N. K. (2006) Nat. Rev. Mol. Cell. Biol. 7, 833-846
2. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J., and Mustelin, T. (2004) Cell 117, 699-711
3. Stoker, A. W. (2005) J. Endocrinol. 185, 19-33
4. Östman, A., Hellberg, C., and Bohmer, F. D. (2006) Nat. Rev. Cancer. 6, 307-320
5. Gee, C. E., and Mansuy, I. M. (2005) Cell. Mol. Life. Sci. 62, 1120-1130
6. Mustelin, T., Vang, T., and Bottini, N. (2005) Nat. Rev. Immunol. 5, 43-57
7. Dolton, G. M., Sathish, J. G., and Matthews, R. J. (2006) Biochem. Soc. Trans. 34, 1041-1045
8. Mustelin, T., Rahmouni, S., Bottini, N., and Alonso, A. (2003) Immunol. Rev. 191, 139-147
9. Vang, T., Miletic, A. V., Arimura, Y., Tautz, L., Rickert, R. C., and Mustelin, T. (2008) Annu. Rev. Immunol. 26, 29-55
10. Gregersen, P. K., Lee, H. S., Batliwalla, F., and Begovich, A. B. (2006) Semin. Immunol. 18, 214-223
11. Hooft van Huijsduijnen, R., Sauer, W., Bombrun, A., and Swinnen, D. (2004) J. Med. Chem. 47, 4142-4146
12. Hooft van Huijsduijnen, R., Bombrun, A., and Swinnen, D. (2002) Drug. Discov. Today 7, 1013-1019
13. Pasquali, C., Curchod, M. L., Walchli, S., Espanel, X., Guerrier, M., Arigoni, F., Strous, G., and Hooft van Huijsduijnen, R. (2003) Mol. Endocrinol. 17, 2228-2239
14. Pilecka, I., Patrignani, C., Pescini, R., Curchod, M.-L., Perrin, D., Xue, Y., Yasenchak, J., Clark, A., Magnone, M. C., Zaratin, P., Valenzuela, D., Rommel, C., and Hooft van Huijsduijnen, R. (2007) J. Biol. Chem. 282, 35405-35415
15. Erbe, D. V., Wang, S., Zhang, Y. L., Harding, K., Kung, L., Tam, M., Stolz, L., Xing, Y., Furey, S., Qadri, A., Klaman, L. D., and Tobin, J. F. (2005) Mol. Pharmacol. 67, 69-77
16. Zinker, B. A., Rondinone, C. M., Trevillyan, J. M., Gum, R. J., Clampit, J. E., Waring, J. F., Xie, N., Wilcox, D., Jacobson, P., Frost, L., Kroeger, P. E., Reilly, R. M., Koterski, S., Opgenorth, T. J., Ulrich, R. G., Crosby, S., Butler, M., Murray, S. F., McKay, R. A., Bhanot, S., Monia, B. P., and Jirousek, M. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 11357-11362
17. Andersen, J. N., Jansen, P. G., Echwald, S. M., Mortensen, O. H., Fukada, T., Del Vecchio, R., Tonks, N. K., and Møller, N. P. (2004) FASEB J. 18, 8-30
18. Thomas, P. E., Wharram, B. L., Goyal, M., Wiggins, J. E., Holzman, L. B., and Wiggins, R. C. (1994) J. Biol. Chem. 269, 19953-19962
19. Aguiar, R. C., Yakushijin, Y., Kharbanda, S., Tiwari, S., Freeman, G. J., and Shipp, M. A. (1999) Blood 94, 2403-2413
20. Pixley, F. J., Lee, P. S., Dominguez, M. G., Einstein, D. B., and Stanley, E. R. (1995) J. Biol. Chem. 270, 27339-27347
21. Wu, L. W., Baylink, D. J., and Lau, K. H. (1996) Biochem. J. 316, 515-523
22. Amoui, M., Baylink, D. J., Tillman, J. B., and Lau, K. H. (2003) J. Biol. Chem. 278, 44273-44280
23. Yang, J. H., Amoui, M., Strong, D. D., and Lau, K. H. (2007) Arch. Biochem. Biophys. 465, 72-81
24. Wharram, B. L., Goyal, M., Gillespie, P. J., Wiggins, J. E., Kershaw, D. B., Holzman, L. B., Dysko, R. C., Saunders, T. L., Samuelson, L. C., and Wiggins, R. C. (2000) J. Clin. Invest. 106, 1281-1290
25. Stepanek, L., Stoker, A. W., Stoeckli, E., and Bixby, J. L. (2005) J. Neurosci. 25, 3813-3823
26. Shintani, T., Ihara, M., Sakuta, H., Takahashi, H., Watakabe, I., and Noda, M. (2006) Nat. Neurosci. 9, 761-769
27. Motiwala, T., Kutay, H., Ghoshal, K., Bai, S., Seimiya, H., Tsuruo, T., Suster, S., Morrison, C., and Jacob, S. T. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 13844-13849
28. Mori, Y., Yin, J., Sato, F., Sterian, A., Simms, L. A., Selaru, F. M., Schulmann, K., Xu, Y., Olaru, A., Wang, S., Deacu, E., Abraham, J. M., Young, J., Leggett, B. A., and Meltzer, S. J. (2004) Cancer. Res. 64, 2434-2438
29. Motiwala, T., Ghoshal, K., Das, A., Majumder, S., Weichenhan, D., Wu, Y. Z., Holman, K., James, S. J., Jacob, S. T., and Plass, C. (2003) Oncogene 22, 6319-6331
30. Suhr, S. M., Pamula, S., Baylink, D. J., and Lau, K. H. (2001) J. Bone Miner. Res. 16, 1795-1803
31. Yang, J. H., Amoui, M., and Lau, K. H. (2007) FEBS. Lett. 581, 2503-2508
32. Pixley, F. J., Lee, P. S., Condeelis, J. S., and Stanley, E. R. (2001) Mol. Cell. Biol. 21, 1795-1809
33. Pixley, F. J., and Stanley, E. R. (2004) Trends Cell. Biol. 14, 628-638
34. Gevrey, J. C., Isaac, B. M., and Cox, D. (2005) J. Immunol. 175, 3737-3745
35. Luangdilok, S., Box, C., Patterson, L., Court, W., Harrington, K., Pitkin, L., Rhys-Evans, P., O-charoenrat, P., and Eccles, S. (2007) Cancer. Res. 67, 7907-7916
36. Wälchli, S., Curchod, M.-L., Pescini Gobert, R., Arkinstall, S., and Hooft van Huijsduijnen, R. (2000) J. Biol. Chem. 275, 9792-9796
37. Grundner, C., Ng, H. L., and Alber, T. (2005) Structure (Camb.) 13, 1625-1634
38. Hooft van Huijsduijnen, R., and Rommel, C. (2006) J. Mol. Med. 84, 802-813
39. Chen, L., Juszczynski, P., Takeyama, K., Aguiar, R. C., and Shipp, M. A. (2006) Blood 108, 3428-3433
40. Camps, M., Ruckle, T., Ji, H., Ardissone, V., Rintelen, F., Shaw, J., Ferrandi, C., Chabert, C., Gillieron, C., Francon, B., Martin, T., Gretener, D., Perrin, D., Leroy, D., Vitte, P. A., Hirsch, E., Wymann, M. P., Cirillo, R., Schwarz, M. K., and Rommel, C. (2005) Nat. Med. 11, 936-943
41. Xu, H., DiIulio, N. A., and Fairchild, R. L. (1996) J. Exp. Med. 183, 1001-1012
42. Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., Cooke, M. P., Walker, J. R., and Hogenesch, J. B. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 6062-6067
43. Kay, R. R., Langridge, P., Traynor, D., and Hoeller, O. (2008) Nat. Rev. Mol. Cell. Biol. 9, 455-463
44. Den Otter, W., De Groot, J. W., Van Basten, C. D., Rademakers, L. H., De Weger, R. A., and Pels, E. (1982) Exp. Mol. Pathol. 36, 403-413
45. Feral, C. C., Rose, D. M., Han, J., Fox, N., Silverman, G. J., Kaushansky, K., and Ginsberg, M. H. (2006) J. Clin. Invest. 116, 715-723
46. Garaczi, E., Szell, M., Janossy, T., Koreck, A., Pivarcsi, A., Buzas, E., Pos, Z., Falus, A., Dobozy, A., and Kemeny, L. (2004) Int. Immunol. 16, 1781-1788
47. Melgar, S., Karlsson, L., Rehnstrom, E., Karlsson, A., Utkovic, H., Jansson, L., and Michaelsson, E. (2008) Int. Immunopharmacol. 8, 836-844
48. Chen, L., Monti, S., Juszczynski, P., Daley, J., Chen, W., Witzig, T. E., Habermann, T. M., Kutok, J. L., and Shipp, M. A. (2008) Blood 111, 2230-2237
49. Jinquan, T., Anting, L., Jacobi, H. H., Glue, C., Jing, C., Ryder, L. P., Madsen, H. O., Svejgaard, A., Skov, P. S., Malling, H. J., and Poulsen, L. K. (2001) J. Immunol. 167, 4405-4413
50. Cambien, B., Pomeranz, M., Schmid-Antomarchi, H., Millet, M., Breittmayer, V., Rossi, B., and Schmid-Alliana, A. (2001) Blood 97, 2031-2037
51. Cambien, B., Pomeranz, M., Millet, M. A., Rossi, B., and Schmid-Alliana, A. (2001) Blood 97, 359-366
52. Braselmann, S., Taylor, V., Zhao, H., Wang, S., Sylvain, C., Baluom, M., Qu, K., Herlaar, E., Lau, A., Young, C., Wong, B. R., Lovell, S., Sun, T., Park, G., Argade, A., Jurcevic, S., Pine, P., Singh, R., Grossbard, E. B., Payan, D. G., and Masuda, E. S. (2006) J. Pharmacol. Exp. Ther. 319, 998-1008
53. Seimiya, H., and Tsuruo, T. (1993) Cell Growth & Differ. 4, 1033-1039