The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activation

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 11922-11929

  Domazet, Ivana ^a   Holleran, Brian J ^a   Martin, Stéphane S ^a   Lavigne, Pierre ^a   Leduc, Richard ^a   Escher, Emanuel ^a   Guillemette, Gaétan ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BINDING ENERGY; CHEMICAL ACTIVATION; LIGANDS; PROTEINS;

CONSTITUTIVELY ACTIVES; COVALENT MODIFICATIONS; FREE SULFHYDRYL GROUPS; G PROTEIN COUPLED RECEPTORS; METHANETHIOSULFONATE-ETHYLAMMONIUM; RECEPTOR ACTIVATION; SECOND TRANSMEMBRANE DOMAIN; TRANS-MEMBRANE DOMAINS;

AMMONIUM COMPOUNDS;

ALKYLATING AGENT; ANGIOTENSIN 1 RECEPTOR; CYSTEINE; LEUCINE; THIOL GROUP; THIOMESYLIC ACID METHYL ESTER; TRYPTOPHAN; WATER; DRUG DERIVATIVE; LIGAND; MESYLIC ACID ETHYL ESTER; METHANETHIOSULFONATE ETHYLAMMONIUM;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL STRAIN COS7; CONTROLLED STUDY; COVALENT BOND; GENE MUTATION; HUMAN; LIGAND BINDING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; REPORTER GENE; ANIMAL; BINDING SITE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; ETHYL METHANESULFONATE; HUMANS; KINETICS; LIGANDS; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ANGIOTENSIN, TYPE 1;

EID: 66449098046     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808113200     Document Type: Article

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