The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation

Molecular Cancer Therapeutics

Volumn 8, Issue 3, 2009, Pages 592-601

  DiMaio, Michael A ^a   Mikhailov, Alexei ^b   Rieder, Conly L ^b   Von Hoff, Daniel D ^c   Palazzo, Robert E ^a,b,d  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b WADSWORTH CENTER   (United States)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^d RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [[2 N (4 METHOXYBENZENESULFONYL)AMINO]STILBAZOLE] 1 OXIDE; ANTINEOPLASTIC AGENT; HMN 176; UNCLASSIFIED DRUG; (E) 4 ((2 N (4 METHOXYBENZENESULFONYL)AMINO)STILBAZOLE)1 OXIDE; (E)-4-((2-N-(4-METHOXYBENZENESULFONYL)AMINO)STILBAZOLE)1-OXIDE; BENZYLIDENE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL KINETICS; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CENTROSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MEIOSIS; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SOMATIC CELL; SPISULA; ANIMAL; CATTLE; DRUG EFFECT; DRUG SCREENING; HELA CELL; METABOLISM; MITOSIS SPINDLE; PROTEIN MULTIMERIZATION; TUMOR CELL CULTURE;

ANIMALS; BENZYLIDENE COMPOUNDS; CATTLE; CENTROSOME; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; MICROTUBULES; MITOTIC SPINDLE APPARATUS; OOCYTES; PROTEIN MULTIMERIZATION; PYRIDINES; SPISULA; TUMOR CELLS, CULTURED;

EID: 66449095268     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0876     Document Type: Article

References (34)

1. Medina-Gundrum L, Cerna C, Gomez L, Izbicka E. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs 2005;23:3-9. (Pubitemid 39505947)
2. Takagi M, Honmura T, Watanabe S, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs 2003;21:387-399
3. Tanaka H, Ohshima N, Ikenoya M, Komori K, Katoh F, Hidaka H. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res 2003;63:6942-6947 (Pubitemid 37322980)
4. Garland LL, Taylor C, Pilkington DL, Cohen JL, Von Hoff DD. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res 2006;12:5182-5189 (Pubitemid 44453347)
5. Allen RD. Fertilization and artificial activation in the egg of the surf-clam, Spisula solidissima. Biol Bull 1953;105:213-239
6. Palazzo RE, Vogel JM. Isolation of centrosomes from Spisula solidissima oocytes. Methods Cell Biol 1999;61:35-56.
7. Palazzo RE, Vaisberg E, Cole RW, Rieder CL. Centriole duplication in lysates of Spisula solidissima oocytes. Science 1992;256:219-221
8. Peilak RM, Gaysinskaya VA, Cohen WD. Formation and function of the polar body contractile ring in Spisula. Dev Biol 2004;269:421-432 (Pubitemid 38521108)
9. Palazzo RE, Brawley JB, Rebhun LI. Spontaneous aster formation in cytoplasmic extracts from eggs of the surf clam. Zoolog Sci 1988;5:603-611
10. Vogel JM, Stearns T, Rieder CL, Palazzo RE. Centrosomes isolated from Spisula solidissima oocytes contain rings and an unusual stoichiometric ratio of α/β tubulin. J Cell Biol 1997;137:193-202. (Pubitemid 27167306)
11. Suprenant KA, Marsh JC. Temperature and pH govern the self-assembly of microtubules from unfertilized sea-urchin egg extracts. J Cell Sci 1987;87:71-84.
12. Suprenant KA, Rebhun LI. Purification and characterization of oocyte cytoplasmic tubulin and meiotic spindle tubulin of the surf clam Spisula solidissima. J Cell Biol 1984;98:253-266 (Pubitemid 14221284)
13. Bornens M, Paintrand M, Berges J, Marty MC, Karsenti E. Structural and chemical characterization of isolated centrosomes. Cell Motil Cytoskeleton 1987;8:238-249
14. Schnackenberg BJ, Khodjakov A, Rieder CL, Palazzo RE. The disassembly and reassembly of functional centrosomes in vitro. Proc Natl Acad Sci U S A 1998;95:9295-9300 (Pubitemid 28506225)
15. Schnackenberg BJ, Palazzo RE. Reconstitution of centrosome microtubule nucleation in Spisula. Methods Cell Biol 2001;67:149-165 (Pubitemid 33798390)
16. Shelanski ML, Gaskin F, Cantor CR. Microtubule assembly in the absence of added nucleotides. Proc Natl Acad Sci U S A 1973;70:765-768
17. Mikhailov A, Cole RW, Rieder CL. DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint. Curr Biol 2002;12:1797-1806 (Pubitemid 35273899)
18. Khodjakov A, Rieder CL. Imaging the division process in living tissue culture cells. Methods 2006;38:2-16. (Pubitemid 41790291)
19. Schoumacher RA, Ram J, Iannuzzi MC, et al. A cystic fibrosis pancreatic adenocarcinoma cell line. Proc Natl Acad Sci U S A 1990;87:4012-4016 (Pubitemid 120015801)
20. Evans T, Rosenthal ET, Youngblom J, Distel D, Hunt T. Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division. Cell 1983;33:389-396
21. Rosenthal ET, Hunt T, Ruderman JV. Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima. Cell 1980;20:487-494 (Pubitemid 10117765)
22. Hershko A, Ganoth D, Pehrson J, Palazzo RE, Cohen LH. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. J Biol Chem 1991;266:16376-16379 (Pubitemid 21907807)
23. Palazzo RE, Vaisberg EA, Weiss DG, Kuznetsov SA, Steffen W. Dynein is required for spindle assembly in cytoplasmic extracts of Spisula solidissima oocytes. J Cell Sci 1999;112:1291-1302 (Pubitemid 29243452)
24. Schnackenberg BJ, Hull DR, Balczon RD, Palazzo RE. Reconstitution of microtubule nucleation potential in centrosomes isolated from Spisula solidissima oocytes. J Cell Sci 2000;113:943-953 (Pubitemid 30179474)
25. Borisy GG, Taylor EW. The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J Cell Biol 1967;34:535-548
26. Suprenant KA, Rebhun LI. Assembly of unfertilized sea urchin egg tubulin at physiological temperatures. J Biol Chem 1983;258:4518-4525
27. Brinkley BR, Goepfert TM. Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected. Cell Motil Cytoskeleton 1998;41:281-288 (Pubitemid 29086464)
28. Brinkley BR. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol 2001;11:18-21. (Pubitemid 32056189)
29. Suddith AW, Vaisberg EA, Kuznetsov SA, Steffen W, Rieder CL, Palazzo RE. Centriole duplication, centrosome maturation and spindle assembly in lysates of Spisula solidissima oocytes. Methods Mol Biol 2001;161:215-228
30. Khodjakov A, Cole RW, Oakley BR, Rieder CL. Centrosome-independent mitotic spindle formation in vertebrates. Curr Biol 2000;10:59-67. (Pubitemid 30079190)
31. Sluder G, Rieder CL. Experimental separation of pronuclei in fertilized sea urchin eggs: chromosomes do not organize a spindle in the absence of centrosomes. J Cell Biol 1985;100:897-903. (Pubitemid 15135350)
32. 1 DNA content mediated by prolonged mitosis. Oncogene 2008;27:4402-4410
33. Hunt T, Luca FC, Ruderman JV. The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo. J Cell Biol 1992;116:707-724
34. Oakley BR, Akkari YN. γ-Tubulin at ten: progress and prospects. Cell Struct Funct 1999;24:365-372